Darrell J Irvine

Professor, Mat'l Sci & Eng and Biological Eng
Department
David H Koch Institute for Integrative Cancer Res
Technology Areas
Chemicals & Materials: Nanotechnology & Nanomaterials, Polymers, Catalysis & Synthesis, Metals / Drug Delivery: Microparticles & Nanoparticles, Vectors & Virus like Particles / Therapeutics: Cell Based Therapy, Proteins & Antibodies, Vaccines, Nucleic Acids, Small Molecules / Drug Discovery and Research Tools: Antibodies, Genomics & Proteomics, Cell Interrogation / Biotechnology: Synthetic Biology, Biomedical Devices & Systems, Sensors & Monitoring, DNA & RNA Editing, Cell Separation / Diagnostics: Assays, Imaging Agents / Biomaterials & Bioelectronics: Health Monitoring
Impact Areas
Healthy Living, Advanced Materials, Uncharted Frontiers

Technologies

Slow Delivery of Antigen and Adjuvant Plus A Delayed Boost for Unexpected Immunogenicity

Technology / Case number: #23762HJ
Shane Crotty / Darrell J Irvine
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
License

Intranasal amphiphile-protein conjugate vaccine

Technology / Case number: #23991H
Brittany Hartwell / Darrell J Irvine
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
License

Universal Redirection of Chimeric Antigen Receptor T Cells Against Solid Tumors via Tumor Cell Membrane-Inserting CAR Ligands

Technology / Case number: #24270H
Angela Zhang / Laura Chen / Alexander Hostetler / Darrell J Irvine
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
License

Controlled Lipid Self-Assembly for Scalable Manufacturing of Next-Generation Immune Stimulating Complexes

Technology / Case number: #24582H
Ivan Pires / Darrell J Irvine / Paula Hammond
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
License

1. Methods for in Vitro Evolution of Constructs Derived from Viruses. 2. Five Mutations Derived from the in Vitro Evolution. 3. Seventeen constructs from the five mutations.

Technology / Case number: #20395H
Ron Weiss / Yingzhong Li / Darrell J Irvine
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
License

Immunostimulatory Nanoparticle Adjuvants

Technology / Case number: #20798HJ
Murillo Silva / Yu Kato / Shane Crotty / Darrell J Irvine
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
License

Programmable Immunostimulation with Structured DNA Nanoparticles

Technology / Case number: #24273H
Mark Bathe / Remi Veneziano / Rebecca Du / Tyson Moyer / Eike-Christian Wamhoff / Benjamin Read / Darrell J Irvine
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
License

Single-Dose Combination Immunotherapy Augments Responses to Checkpoint Blockades for the Treatment of Cancer

Technology / Case number: #21150H
Chensu Wang / Darrell J Irvine / Karl Dane Wittrup
Technology Areas: Therapeutics
Impact Areas: Healthy Living
License

Uses of Amphiphiles in Immune Cell Therapy and Compositions Therefore

Technology / Case number: #21411H
Peter DeMuth / Darrell J Irvine
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
License

STING Agonist Delivery by Lipid Nanodiscs for Tumor Immunotherapy

Technology / Case number: #21441HJ
Eric Dane / Masanori Okaniwa / Darrell J Irvine
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

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