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Tuning Chloroplast Transgene Expression from Synthetic Operon

Technology / Case number: #25494
Christopher Voigt / Qiguo Yu
Technology Areas: Agriculture & Food / Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Enhanced Endogenous Recombination for Gene Therapy and Genetic Engineering

Technology / Case number: #20008M
Guoping Feng / Jonathan Wilde / Tomomi Aida / Martin Wienisch / Qiangge Zhang
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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1. Methods for in Vitro Evolution of Constructs Derived from Viruses. 2. Five Mutations Derived from the in Vitro Evolution. 3. Seventeen constructs from the five mutations.

Technology / Case number: #20395H
Ron Weiss / Yingzhong Li / Darrell Irvine
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Intra-Tumoral Injection of Cytotoxic Chemotherapy-Treated Tumor Cells in Combination with Systemic Immune Checkpoint Blockade for Cancer Treatment

Technology / Case number: #21498H
Ganapathy Sriram / Lauren Milling / Darrell Irvine / Michael Yaffe
Technology Areas: Diagnostics / Therapeutics
Impact Areas: Healthy Living
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Fusion Capsid Therapy for COVID-19 and Applies to Other Viruses: Universal "Dominant" Antiviral to Prevent Virus Evolution and Future Pandemics (DNA/RNA/Protein)

Technology, Tangible Property / Case number: #22801MH
Edward Boyden / Robert Langer / Alexi Choueiri / Yong Qian / Bowen Li / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Control Replication and Transcription of Self-Replicating RNA in Responses to Small Molecule TMP

Technology / Case number: #22331H
Ron Weiss / Yingzhong Li / Jan Lonzaric / Parisa Yousefpour / Darrell Irvine
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Compositions for the Conditional Delivery of Macromolecules and Combination Therapeutics

Technology / Case number: #24492H
Chayanon Ngambenjawong / Edward Tan / Qian Zhong / Sangeeta Bhatia
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Lipid Nanoparticles for Drug Delivery to Microglia in the Brain

Technology / Case number: #23156P
Li-Huei Tsai / Owen Fenton / Joel Blanchard / Robert Langer / Jason Andresen / Julia Bonner / William Ralvenius
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Novel Peptides to Inhibit Ena/VASP Proteins

Technology / Case number: #22897J
Amy Keating / Theresa Hwang / Meucci IIunga / Sara Parker / Ghassan Mouneimne / Samantha Hill
Technology Areas: Chemicals & Materials / Diagnostics / Therapeutics
Impact Areas: Healthy Living
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Nucleic Acid-Conjugated Polymeric Nanoparticles for Gene Therapy

Technology / Case number: #23628J
Natalie Artzi / Pere Dosta Pons / Alexander Cryer
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Programmable Immunostimulation with Structured DNA Nanoparticles

Technology / Case number: #24273H
Mark Bathe / Remi Veneziano / Rebecca Du / Tyson Moyer / Eike-Christian Wamhoff / Benjamin Read / Darrell Irvine
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Autocatalytic Base Editing for RNA-Responsive Translational Control

Technology / Case number: #24552YJ
James Collins / Raphael Gayet / Katherine Ilia / Shiva Razavi / Nathaniel Tippens / Kehan Zhang / Xiaoyu Chen / Jonathan Chen / Makoto Lalwani
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Multi-Targeted, Tunable, Sustained Delivery of Drugs and Other Payloads to Charged Avascular Tissues

Technology / Case number: #21303
Yamini Krishnan / Alan Grodzinsky
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Targeting Lung Microbiota and its Responding Immune Pathways for Lung Cancer Treatment

Technology / Case number: #20602HRJ
Paul Blainey / Chengcheng Jin / Georgia Lagoudas / Tyler Jacks
Technology Areas: Diagnostics / Therapeutics
Impact Areas: Healthy Living
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RNA-Loaded Lipid Nanoparticle (LNP)

Technology, Tangible Property / Case number: #24973H
Byungji Kim / Darrell Irvine
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Target for Modulating Body Mass

Technology / Case number: #21326
Nikola Ivica / Yingzhong Li / Ting Dong / Jianzhu Chen
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Programmable RNA Writing with the Novel RNA-Guided RNA-Targeting CRISPR-Cas7-11 Enzyme

Technology / Case number: #24072
Omar Abudayyeh / Jonathan Gootenberg / Wenyuan Zhou / Cian Schmitt-Ulms / Alisan Kayabolen
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Structure and Engineering of the Type III-E CRISPR-Cas7-11 Effector Complex

Technology / Case number: #23945J
Omar Abudayyeh / Jonathan Gootenberg / Wenyuan Zhou / Hiroshi Nishimasu / Kazuki Kato / Cian Schmitt-Ulms
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Intraperitoneal Injection of Nanoparticles Results in Near Perfect Localization Within Peritoneal Tumor Deposits

Technology / Case number: #19352
Xiangnan Dang / Paiman Ghoroghchian / Zhimin Tao / Angela Belcher
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Systems, Methods, And Compositions For RNA-Guided RNA-Targeting CRISPR Effectors from Type III Systems

Technology / Case number: #23239
Omar Abudayyeh / Jonathan Gootenberg
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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