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A Platform for Continuous Directed Evolution in Human Cells

Technology / Case number: #19909
Matthew D. Shoulders / Samuel Hendel / Chet Berman / Christopher Moore / Louis Papa
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Efficient and Reliable Transmission of Sparse Signals in Wireless Sensor Networks

Technology / Case number: #18468
Anantha Chandrakasan / Georgios Angelopoulos / Muriel Medard
Technology Areas: Communication Systems / Computer Science
Impact Areas: Connected World
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Compositions and Methods to Increase Muscular Strength Without Exercise

Technology / Case number: #19768
Roger Kamm / Vivek Sivathanu
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Drug Delivery Based on Bistable Membrane

Technology / Case number: #17624
Michael Cima
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Potent Agelastatin Derivatives as Modulators for Cancer Invasion and Metastasis

Technology / Case number: #19505J
Mo Movassaghi / Kun Xu / Alyssa Antropow / Rachel Buchsbaum
Technology Areas: Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers, Advanced Materials
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Continuous Freeze-Drying of Pharmaceuticals and Biopharmaceuticals in Unit Doses

Technology / Case number: #19494J
Bernhardt Trout / Capozzi Carlo / Roberto Pisano
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Engineered Phagemids for Non-Lytic, Targeted Antibacterial Technologies

Technology / Case number: #18186HJY
James Collins / Michael Lobritz / Prerna Bhargava / Russell-John Krom
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Novel Peptidic Agents for Targeting Chemoresistant Anti-Apoptotic Mcl-1

Technology / Case number: #18162
Amy Keating / Raheleh Rezaei Araghi
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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PNA Amphiphile Adjuvant Delivery Vehicles

Technology / Case number: #18878H
Darrell J Irvine / Eric Dane
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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M13 Phage Assembly System for Optimal Blood Trafficking, Tumor Penetration, and Passage Across the Blood Brain Barrier

Technology / Case number: #19438
Angela Belcher / Fred Lam / Uyanga Tsedev
Technology Areas: Drug Delivery / Sensing & Imaging / Therapeutics
Impact Areas: Healthy Living
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Open-Ended, Dicer-Cleavable Concatemeric siRNA Generated by Rolling Circle Transcription

Technology / Case number: #18076
Paula Hammond / Kevin Shopsowitz / Connie Wu
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Development of Multi-Specific Antibody-Serum Albumin Fusion Proteins Targeting Multiple Human and Murine CXC (ELR+) Chemokines

Technology / Case number: #19355JQ
Karl Dane Wittrup / Andrew Luster / Alessandro Angelini
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Diazene Directed Modular Synthesis of Oligocyclotryptamines

Technology / Case number: #18747
Mo Movassaghi / Petra Lindovska
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers, Advanced Materials
License

Discovery of Self-Labeling Miniproteins

Technology / Case number: #18742
Bradley L. Pentelute / Ethan Evans
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Uncharted Frontiers, Advanced Materials
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Manufacture of Thermo-Responsive Hydrogel Composing of Drug-Nanocapsule for Sustainable Release of Ibuprofen, Ofloxacin and Dexamethasone

Technology / Case number: #18561
Jeremiah A. Johnson / Farrukh Vohidov / Qixian Chen
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Ground-Based System for Geolocation of Perpetrators of Aircraft Laser Strikes

Technology / Case number: #18562L
James Kuchar / Erin Tomlinson / Richard Westhoff / Julia Fang / Brian Saar / Tom Reynolds
Technology Areas: Communication Systems / Computer Science / Electronics & Photonics
Impact Areas: Connected World
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Structured DNA Conjugates

Technology / Case number: #18588
Mark Bathe / Hyungmin Jun / Tyson Shepherd / Remi Veneziano / Sakul Ratanalert
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Synthetic Hybrid Receptor and Genetic Circuit in Probiotic Bacteria to Detect Enteric Pathogenic Microorganisms

Technology / Case number: #17801HJ
James Collins / Douglas Cameron / Ning Mao
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Layer-by-Layer Nanoparticles for Cytokine Therapy in Cancer Treatment

Technology / Case number: #20027H
Darrell J Irvine / Talar Tokatlian / Santiago Correa Echavarria / Antonio Barberio / Mariane Melo / Erik Dreaden / Paula Hammond
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
License

Method and Apparatus for Message Fractionation and Physical Layer Channel Assignment for Multiuser Detection-Enabled Wireless Communication Among Adaptive Interference

Technology / Case number: #17478L
Rachel Learned / Prabahan Basu
Technology Areas: Communication Systems / Electronics & Photonics
Impact Areas: Connected World
License

The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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