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Programmable Immunostimulation with Structured DNA Nanoparticles

Technology / Case number: #24273H
Darrell J Irvine / Benjamin Read / Eike-Christian Wamhoff / Tyson Moyer / Rebecca Du / Remi Veneziano / Mark Bathe
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Multiplexed Expansion Revealing

Technology / Case number: #24562MH
Edward Stuart Boyden / Margaret Schroeder / Jinyoung Kang
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Tool for Spatially Targeted Access and Placement of Hardware or Drugs in Deep or Consolidated Tissues

Technology / Case number: #25071
Robert Langer / Alexander Madinger / Shriya Sruthi Srinivasan
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living
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Methods for Machine-Learning Guided Protein Design

Technology / Case number: #25084
Omar Abudayyeh / Matteo Di Bernardo / Kaiyi Jiang / Jonathan S. Gootenberg
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Analysis, Screening, and Selection for Soluble Protein Function for the Prevention of Infection

Technology / Case number: #25312J
Brandon DeKosky
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Molecular Time Capsules Enable Transcriptomic Recording in Living Cells

Technology / Case number: #25337
Gene-Wei Li / Dylan McCormick / Jack Rubien / Mirae Parker
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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An Efficient Bioconjugation Technology for Site-Selective Covalent Modification of Antibodies using an Engineered Affinity Peptide

Technology / Case number: #25358
Bradley L. Pentelute / Katsushi Kitahara / Aurelie Rondon / Heemal Dhanjee / Jacob Rodriguez / Andrei Loas
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Surgical Cautery Artifact Removal from Electrodermal Activity Data

Technology / Case number: #23525PJ
Emery N Brown / Sandya Subramanian / Riccardo Barbieri
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology
Impact Areas: Healthy Living
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A Fabrication-Free Microfluidic Device for Scalable, High-Volume Bacterial Electroporation

Technology / Case number: #23552
Cullen R. Buie / Sijie Chen / Po-Hsun Huang
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Nucleic Acid-Conjugated Polymeric Nanoparticles for Gene Therapy

Technology / Case number: #23628JQ
Natalie Artzi / Alexander M Cryer / Pere Dosta Pons
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Engineered Alum-binding SARS-CoV-2 Immunogens

Technology / Case number: #23632H
Darrell J Irvine / Kristen Rodrigues / Sergio Rodriguez / Neil Dalvie / J. Christopher Love
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Peptide-Encoded Libraries of Small Molecules for De Novo Drug Discovery

Technology / Case number: #23712
Stephen Buchwald / Simon Roessler / Nathalie Grob / Bradley L. Pentelute
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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High-Throughput and High-Precision Measurement of Single-Cell Density

Technology / Case number: #23740
Scott Manalis / Teemu Miettinen / Weida Wu
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Intracellular Molecular Recording and Memory via Protein Self-Assembly

Technology / Case number: #23746HPM
Edward Stuart Boyden / Changyang Linghu
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Slow Delivery of Antigen and Adjuvant Plus A Delayed Boost for Unexpected Immunogenicity

Technology / Case number: #23762HJ
Darrell J Irvine / Shane Crotty
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Activity-based Cell Sorting

Technology / Case number: #23765HJ
Sangeeta Bhatia / Ava Soleimany / Jesse Kirkpatrick
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
License

DNA-Dye Assembly Based Single-Molecule Fluorescence Lifetime Imaging Probes

Technology / Case number: #23780
Mark Bathe / Jiajia Guo / Gabriela Schlau-Cohen / Xiao Wang / Stephanie Hart
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics
Impact Areas: Healthy Living
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Method and Apparatus for Inferring Elevated Pulmonary Capillary Wedge Pressures from Single-Lead Electrocardiogram Telemetry Data

Technology, Software / Case number: #23955J
Collin M Stultz / Eugene Pomerantsev / Ridwan Alam / Daphne Schlesinger
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biomaterials & Bioelectronics / Biotechnology
Impact Areas: Healthy Living
License

Activatable Antimicrobial Peptides and Uses Thereof

Technology / Case number: #24024H
Sangeeta Bhatia / Chayanon Ngambenjawong
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
License

Fabrication of Polymeric Microneedles with Hollow and Porous Tips via a Simple Micromolding Process Assisted by Ionic Salts

Technology / Case number: #24093
Benedetto Marelli / Doyoon Kim
Technology Areas: Agriculture & Food / Chemicals & Materials
Impact Areas: Advanced Materials
License

The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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