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Locally Delivered Therapeutics and Combinations for Expedited Passage of Urinary Stones

Technology / Case number: #19454JQ
Michael Cima / Brian Eisner / Xiang Li
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Mammalian Synthetic Biology Approaches for the Precise Control of mAb N-Glycosylation (Pfizer-MIT PTM Track 2 Interim Joint Summary Document)

Technology / Case number: #19972J
Timothy K Lu / Bruno Figueroa / John Scarcelli / Jeffrey Marshall / Richard Cornell / Giyoung Jung / Michelle Chang / Leonid Gaidukov / Wen Tseng / Nevin Summers / Ron Weiss
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Adaptive Self-Sealing Microfluidic Gear Pump

Technology / Case number: #20081
Anette Hosoi / Tianshi Fang / Qing Zhang / Irmgard Bischofberger / Youzhi Liang / Yongbin Sun
Technology Areas: Chemicals & Materials / Industrial Engineering & Automation
Impact Areas: Advanced Materials
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Thermally-Drawn Li-Ion Fibre Batteries

Technology / Case number: #20099
Yoel Fink / Jung Tae Lee / Tural Khudiyev / Benjamin Grena / Chong Hou
Technology Areas: Chemicals & Materials / Electronics & Photonics
Impact Areas: Advanced Materials
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Advanced Architectures and Operating Principles for Electrochemical Neuro-Modulation

Technology / Case number: #20280J
Jongyoon Han / Matthew Flavin / Daniel Freeman
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living
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Gastric-Resident Devices for Gram-level Drug Delivery

Technology / Case number: #20379JQ
Robert Langer / Daniel Minahan / Taylor Bensel / Malvika Verma / Tyler Grant / Andrew Bellinger / Giovanni Traverso
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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1. Methods for in Vitro Evolution of Constructs Derived from Viruses. 2. Five Mutations Derived from the in Vitro Evolution. 3. Seventeen constructs from the five mutations.

Technology / Case number: #20395H
Darrell J Irvine / Yingzhong Li / Ron Weiss
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Nanosensors for Detecting and Imaging of Cancer Metastasis

Technology / Case number: #20490H
Sangeeta Bhatia / Liang Hao
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics
Impact Areas: Healthy Living
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PROTAC Derivatives with Functional Handles for Chemical Conjugation/Modification

Technology / Case number: #20788J
Jeremiah A. Johnson / Aiden Wang / Michael Agius / Irene Ghobrial / Alexandre Detappe / Hung Nguyen / Yivan Jiang
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Immunostimulatory Nanoparticle Adjuvants

Non-Exclusively Licensed Technology / Case number: #20798HJ
Darrell J Irvine / Shane Crotty / Yu Kato / Murillo Silva
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Structures with Complex Geometries and Controlled Porosity in Micrometer to Meter Dimensions Produced at Large Scale

Technology / Case number: #21002J
Yoel Fink / Ian Tafel / Dena Shahriari / Zi Jie Gabriel Loke / Polina Anikeeva
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living, Advanced Materials
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Strong Adhesion of Wet Conducting Polymers on Diverse Substrates

Technology / Case number: #21093
Xuanhe Zhao / Akihisa Inoue / Hyunwoo Yuk
Technology Areas: Biomaterials & Bioelectronics / Chemicals & Materials
Impact Areas: Healthy Living, Advanced Materials
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Circular, Strained Zymogen

Technology / Case number: #21110J
Ronald T Raines / Ian Windsor
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Novel Chimeric Antigen Receptor Signaling Domains Derived via Activity-based Directed Evolution

Technology / Case number: #21116
Michael Birnbaum / Taeyoon Kyung
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Optimization of Circular Single Stranded DNA using M13 Phage

Technology / Case number: #21211
Angela Belcher / Tae-Gon Cha / Uyanga Tsedev / Christopher Voigt
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Characterization and Utilization of a Subgenomic Promoter Mutant Library for Tuning Expression of Multiple Transgenes from Alphavirus Replicons

Technology / Case number: #21309
Ron Weiss / Jin Huh
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Concepts and Methods for Constructing Elastic Tissue-Hydrogel Hybrids

Technology / Case number: #21394
Kwanghun Chung / Taeyun Ku
Technology Areas: Chemicals & Materials / Diagnostics
Impact Areas: Healthy Living, Advanced Materials
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Uses of Amphiphiles in Immune Cell Therapy and Compositions Therefore

Technology / Case number: #21411H
Darrell J Irvine / Peter DeMuth
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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STING Agonist Delivery by Lipid Nanodiscs for Tumor Immunotherapy

Technology / Case number: #21441HJ
Darrell J Irvine / Masanori Okaniwa / Eric Dane
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Synthesis of Potent Epidithiodiketopiperazines Designed for Facile Derivatization

Technology / Case number: #21469
Mo Movassaghi / Tony Scott / Chase Olsson / Jaime Cheah / Joshua Payette
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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