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A Multi-Pathway Reporter System that Interrogates Repair of DNA Double-Strand Breaks with Applications for Diagnosis and Therapeutic Treatment of Cancer and Neurodegenerative Diseases

Technology / Case number: #25444
Alex Kruswick / Michael Yaffe
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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A Machine Learning-guided Whole-Organ Optical Imaging Technique for Non-destructive Identification of Early Pre-Cancer Lesions and Harvesting of Viable Cells from the same for Organoid Culture

Technology / Case number: #25480
Neelkanth Bardhan / Vivek Rastogi / Angela Belcher
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Electronics & Photonics / Sensing & Imaging
Impact Areas: Healthy Living
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Hyperlactatemia Prediction

Technology / Case number: #18128J
Andrew Reisner / Thomas Heldt / Michael Filbin / Max Dunitz / George Verghese
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biomaterials & Bioelectronics / Computer Science
Impact Areas: Healthy Living
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System and Method for Automated Ovarian Follicular Monitoring

Technology / Case number: #19173PJ
Emery Brown / Rose Faghih / Aaron Styer
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Communication Systems / Computer Science
Impact Areas: Healthy Living
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TRAV-007 (Genome Sequencing) 62/790,799

Technology / Case number: #22143J
Robert Kimmerling / Mark Stevens / Keith Ligon / Scott Manalis
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Intra-Tumoral Injection of Cytotoxic Chemotherapy-Treated Tumor Cells in Combination with Systemic Immune Checkpoint Blockade for Cancer Treatment

Technology / Case number: #21498H
Ganapathy Sriram / Lauren Milling / Darrell Irvine / Michael Yaffe
Technology Areas: Diagnostics / Therapeutics
Impact Areas: Healthy Living
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Multiplexed in Vivo Disease Sensing with Nucleic Acid-Barcoded Reporters enabling CRISPR-Cas-based Detection

Technology / Case number: #21723H
Liangliang Hao / Renee Zhao / Chayanon Ngambenjawong / Sangeeta Bhatia
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics
Impact Areas: Healthy Living
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Nanosensors for Detecting and Imaging of Cancer Metastasis

Technology / Case number: #20490H
Liangliang Hao / Sangeeta Bhatia
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics
Impact Areas: Healthy Living
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Single Molecule Assays for Ultrasensitive Detection of Analytes

Technology / Case number: #24450JY
Tyler Dougan / Connie Wu / David Walt / Richard Novak
Technology Areas: Biotechnology / Diagnostics
Impact Areas: Healthy Living
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Low Power Battery and Signaling System

Technology / Case number: #25211J
Carlo Giovanni Traverso / Adam Gierlach / James McRae / Yeseul Jeon / Ian Ballinger / Anantha Chandrakasan
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Communication Systems / Energy & Distribution
Impact Areas: Healthy Living, Connected World
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Medical Recordkeeping Microneedles

Technology / Case number: #24923
Ana Jaklenec / Robert Langer / Maria Kanelli / Jooli Han / Yang Liu / Frederic Durand (he/him/his)
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Methods for Machine-Learning Guided Protein Design

Technology / Case number: #25084
Omar Abudayyeh / Jonathan Gootenberg / Kaiyi Jiang / Matteo Di Bernardo
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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An Ingestible Stackable Gastric Resident System for Gastrointestinal Applications

Technology / Case number: #25424J
Carlo Giovanni Traverso / Robert Langer / Seungho Lee / Matt Murphy
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Communication Systems
Impact Areas: Healthy Living
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Tiny Nanoparticles for Magnetic Resonance Imaging Applications

Technology / Case number: #18105
He Wei / Oliver Bruns / Eric Hansen / Moungi Bawendi
Technology Areas: Chemicals & Materials / Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living, Advanced Materials
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Chemiresistive Sensors Based on Carbon Nanotubes and Transition Metal Complexes

Technology / Case number: #20300
Sibo Lin / Timothy Swager
Technology Areas: Chemicals & Materials / Communication Systems / Sensing & Imaging
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TRAV-005 (Needles) 62/795,857

Technology / Case number: #22144J
Selim Olcum / Robert Kimmerling / David Weinstock / Scott Manalis
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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A Modified Viscoelastic Assay Rapidly Unmasks Pathological Fibrinolysis Phenotypes in a Wide Spectrum of Human Diseases

Technology / Case number: #19496J
Christopher Barrett / Ernest Moore / Hunter Moore / Michael Yaffe
Technology Areas: Biotechnology / Diagnostics
Impact Areas: Healthy Living
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Shortwave Infrared Detection of Fluorescent Dyes

Technology / Case number: #18530
Oliver Bruns / Tulio Valdez / Jessica Carr / Daniel Franke / Marianne Aellen / Moungi Bawendi
Technology Areas: Communication Systems / Sensing & Imaging
Impact Areas: Healthy Living
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Eliminating Channel Feedback in Next-Generation Cellular Networks

Technology / Case number: #18679
Dina Katabi / Hariharan Rahul / Swarun Suresh Kumar / Deepak Vasisht
Technology Areas: Communication Systems / Computer Science
Impact Areas: Connected World
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Planar Luneburg Lens System for Two-Dimensional Optical Beam Steering

Technology / Case number: #21298L
Jeffrey Herd / Cheryl Sorace-Agaskar / Paul Juodawlkis / Suraj Bramhavar / Boris Kharas / Josue Lopez / Samuel Kim / Jamison Sloan / Steven Johnson / George Barbastathis / Marin Soljacic
Technology Areas: Chemicals & Materials / Communication Systems / Electronics & Photonics
Impact Areas: Connected World, Advanced Materials
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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