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Programmable Gene Insertion with Paired Targeting Guides

Technology / Case number: #24104
Omar Abudayyeh / Jonathan S. Gootenberg
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Vaccine Nanotechnology and Uses Thereof

Technology / Case number: #12788J
Robert Langer / Matteo Iannacone / Elliot Moseman / Tobias Junt / Ulrich Von Andrian / Pamela Basto / Liangfang Zhang / Frank Alexis / Omid Farokhzad
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Universal RNA-Binding Protein Based on the Pumilio Domain Architecture

Technology / Case number: #17629TE
Edward Stuart Boyden / Daniel Martin Alarcon / Katarzyna Adamala
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Biomarkers and Therapeutics for Autism Spectrum Disorders

Technology / Case number: #13589P
Mriganka Sur / Damon Page
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Generation of Specialized, High-Value Cells and Tissues from Human Induced Pluripotent Stem Cells by Recapitulating Early Embryogenesis Using Gata Factor-Induced Endoderm

Technology, Tangible Property / Case number: #16205
Ron Weiss / Mohammad Reza Ebrahimkhani / Patrick Guye
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Method for High Efficiency in Vivo Gene Editing

Technology / Case number: #17117H
Tyler Jacks / Hao Yin / Joseph Dorkin / Wen Xue / Daniel Anderson
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Programmable Drug Delivery Profiles of Tumor-Targeted Bacteria

Technology / Case number: #15818H
Sangeeta Bhatia / Tal Danino
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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System for Portable Body Surface Acquisition

Technology / Case number: #17269
Luca Giancardo / Aurelien Bourquard / Tobias Hahn / Carlos Sanchez Mendoza
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living
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High-Throughput Screening Metabolic Flux Biosensor

Technology / Case number: #16813JW
Gerald Fink / Jose Avalos / Gregory Stephanopoulos
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Epigenetic Mechanisms Re-Establish Access to Long-Term Memory After Neuronal Loss

Technology / Case number: #12467HPBJ
Stuart Schreiber / Stephen Haggarty / Li-Huei Tsai / Andre Fischer / Weiping Tang
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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In Vivo Targeting of T-Cells with Antibody- and Cytokine Conjugated Liposomes

Technology / Case number: #16405H
Darrell J Irvine / Brandon Kwong / Yuan Zhang / Yiran Zheng
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Use of Ranking Methods in Machine Learning to Prioritize Chemical Compounds for Drug Discovery

Technology / Case number: #14011
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science
Impact Areas: Healthy Living
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Tough, Thermoreversible Hydrogels from the Arrested Phase Separation of Elastin-Like Polypeptides: Simple, Injectable, Biocompatible Substrates for the Engineering of Load-Bearing Tissues

Technology / Case number: #17430
Bradley D. Olsen / Reginald Avery / Matthew Glassman
Technology Areas: Biomaterials & Bioelectronics / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Thermally-Gelling Injectable Hydrogel Composites for Therapeutic Delivery

Technology / Case number: #25878
Patrick Doyle / Talia Zheng
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Synthesis and Anticancer Activity of Agelastatin Alkaloids

Technology / Case number: #16512J
Mo Movassaghi / Paul Hergenrother
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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  • Women's Health
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Translating Text to, Merging, and Optimizing Graphical User Interface Tasks

Technology / Case number: #13972
Martin Rinard / Nate Kushman / Regina Barzilay / Satchuthananthavale Branavan / Dina Katabi
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science / Industrial Engineering & Automation
Impact Areas: Connected World
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A Single-Walled Carbon Nano-Tube/Chitosan Hydrogel Array for the Label-Free, Optical Detection of Protein-Protein Interactions

Technology / Case number: #14201
Michael S. Strano / Nigel Reuel / Jin Ho Ahn / Paul Barone / Jong Ho Kim
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Sensing & Imaging / Therapeutics
Impact Areas: Healthy Living
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A Device and a Method for Real-Time Dynamic Analysis and Guidance (RTAG) of On-Line Learning

Technology / Case number: #17389
Emery N Brown / Anne Smith / Demba Ba
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science
Impact Areas: Connected World
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A Data-Driven System for Optimal Vehicle Fleet Dimensioning and Real-Time Dispatching Based on Shareability Networks

Technology / Case number: #18459
Carlo Ratti / Giovanni Resta / Paolo Santi
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Industrial Engineering & Automation
Impact Areas: Connected World, Advanced Materials
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Cystic Fibrosis Correction with Programmable Genomic Editing

Technology / Case number: #24666
Omar Abudayyeh / Christopher Fell / Matthew Yarnall / Jonathan S. Gootenberg
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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