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Methods for Machine-Learning Guided Protein Design

Technology / Case number: #25084
Omar Abudayyeh / Matteo Di Bernardo / Kaiyi Jiang / Jonathan S. Gootenberg
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Augmentation of T and B Cell Activation with a Novel Cysteine Protease Linker Sequence

Technology / Case number: #25338
Tyler Jacks / Sean-Luc Shanahan
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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An Efficient Bioconjugation Technology for Site-Selective Covalent Modification of Antibodies using an Engineered Affinity Peptide

Technology / Case number: #25358
Bradley L. Pentelute / Katsushi Kitahara / Aurelie Rondon / Heemal Dhanjee / Jacob Rodriguez / Andrei Loas
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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A Machine Learning-guided Whole-Organ Optical Imaging Technique for Non-destructive Identification of Early Pre-Cancer Lesions and Harvesting of Viable Cells from the same for Organoid Culture

Technology / Case number: #25480
Angela Belcher / Vivek Rastogi / Neelkanth Manoj Bardhan
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Electronics & Photonics / Sensing & Imaging
Impact Areas: Healthy Living
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Tuning Chloroplast Transgene Expression from Synthetic Operon

Technology / Case number: #25494
Christopher Voigt / Qiguo Yu
Technology Areas: Agriculture & Food / Biotechnology / Therapeutics
Impact Areas: Healthy Living
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All-Optical Holographic Implementation of Constant-Depth Quantum Circuits

Technology / Case number: #21655
Dirk R Englund / Donggyu Kim
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science / Sensing & Imaging
Impact Areas: Uncharted Frontiers, Advanced Materials
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Machine Learning for Accelerated IBFD Tuning

Technology / Case number: #22007L
Ken Kolodziej / Aidan Cookson / Bradley Perry
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Communication Systems / Computer Science
Impact Areas: Connected World, Advanced Materials
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Certified Control

Technology / Case number: #21653
Daniel Jackson / Xin Zhang / Nikos Gonzalez / Mike Wang / FengPing Angela Leong / Dimitris Koutentakis / Jonathan DeCastro / Soonho Kong
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Communication Systems / Industrial Engineering & Automation
Impact Areas: Sustainable Future, Connected World
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Joint Qubit Manipulation and Readout for Majorana-Based Quantum Information Processing

Technology / Case number: #20208
Liang Fu / Constantin Schrade
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Chemicals & Materials / Computer Science / Electronics & Photonics
Impact Areas: Uncharted Frontiers, Advanced Materials
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Brain-Computer Interface for User's Visual Focus Detection

Technology / Case number: #20246
Sanjay Emani Sarma / Alexandre Armengol Urpi
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology
Impact Areas: Healthy Living, Uncharted Frontiers, Connected World
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Multi-Targeted, Tunable, Sustained Delivery of Drugs and Other Payloads to Charged Avascular Tissues

Technology / Case number: #21303
Alan Grodzinsky / Yamini Krishnan
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Distributed Training and Management of Al Powered Robots using Teleoperation via Virtual Spaces

Technology / Case number: #20397
Daniela Rus / Changhyun Choi / Aidan Fay / Jeffrey Lipton
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science / Industrial Engineering & Automation
Impact Areas: Uncharted Frontiers, Connected World
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Purification of Substances Using CO2 Sub-and Super-Critical Fluid Chromatography

Technology / Case number: #19742
Clark Colton / John MacKay / Truong Cai / Tony Elian / Mariya Layurova / Veronica Wilson / John Moses / William Dalzell
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Sustainable Future
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Dysferlinopathy Compounds

Technology, Tangible Property / Case number: #22496
Leonard Guarente / Naoomi Tominaga / Kana Tominaga / Eric O Williams / Mohan Viswanathan
Technology Areas: Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Targeting Dendritic Cell Lectins with Glycosylated Particles Containing TLR Ligands Facilitates Efficient Immune Responses

Technology / Case number: #24570J
Laura L Kiessling / Robert Hincapie / Mohammad Murshid Alam / M.G. Finn / Valerie Lensch
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Synthetic Mucin Glycans as Antifungal Agents

Technology / Case number: #24073J
Katharina Ribbeck / Rachel Hevey / Julie Takagi
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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  • Women's Health
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Synthesis of Covalent Protein Dimers that can Inhibit MYC-Driven Transcription

Technology / Case number: #23305WJ
Stephen Buchwald / Charles Li / Susana Hawken / Ann Boija / Muhammad Jbara / Jacob Rodriguez / Andrei Loas / Sebastian Pomplun / Carly Schissel / Isaac Klein / Bradley L. Pentelute
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Targeting Lung Microbiota and its Responding Immune Pathways for Lung Cancer Treatment

Technology / Case number: #20602HRJ
Tyler Jacks / Georgia Lagoudas / Chengcheng Jin / Paul Blainey
Technology Areas: Diagnostics / Therapeutics
Impact Areas: Healthy Living
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RNA-Loaded Lipid Nanoparticle (LNP)

Technology, Tangible Property / Case number: #24973H
Darrell J Irvine / B.j. Kim
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Target for Modulating Body Mass

Technology / Case number: #21326
Jianzhu Chen / Ting Dong / Yingzhong Li / Nikola Ivica
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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