Augmenting In Situ Sequencing with In Vitro Sequencing Information
Non-Exclusively Licensed
Invention type: Technology
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Case number: #19919TEYJ
The invention provides in situ nucleic acid sequencing to be conducted in biological specimens that have been physically expanded. The invention leverages the techniques for expansion microscopy (ExM) to provide new methods for in situ sequencing of nucleic acids in a process referred to herein as “expansion sequencing” (ExSEQ).
Researchers
Edward Stuart Boyden
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Jonathan Scheiman
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Daniel Goodwin
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Andrew Payne
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Shahar Alon
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Evan Daugharthy
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Fei Chen
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Asmamaw Wassie
Departments: Department of Brain and Cognitive Sciences
Technology Areas: Biotechnology: DNA & RNA Editing, Synthetic Biology / Diagnostics: Assays / Drug Discovery and Research Tools: Cell Interrogation, Genomics & Proteomics
Impact Areas: Healthy Living
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augmenting in situ nucleic acid sequencing of expanded biological samples with in vitro sequence information
United States of America | Granted | 10,526,649
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