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Zwitterionic Polymer Functionalized Lipid Nanoparticles for Delivery of mRNA

Technology / Case number: #24662
Robert Langer / Sushil Lathwal / Allen Jiang / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Robocap

Technology / Case number: #24836J
Robert Langer / Amro Alshareef / Shriya Sruthi Srinivasan / Giovanni Traverso
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Modular MicroRNA Expression from Self-Replicating RNA (Replicons)

Technology / Case number: #25464
Ron Weiss / Tea Crnkovic
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Scalable and High throughput Assembly of Layer-by-Layer Nanoparticles

Technology / Case number: #25554H
Darrell J Irvine / / Ivan Pires / Paula Hammond
Technology Areas: Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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Production of Stable Non-Polyadenylated RNAs

Technology / Case number: #15860
Phillip Sharp / Jeremy Wilusz
Technology Areas: Biotechnology / Drug Delivery
Impact Areas: Healthy Living
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Compositions for Protein Labeling Using Lipoic Acid Ligases

Technology / Case number: #15299J
Alice Ting / David Baker / Florian Richter / Lucas Nivon / Daniel Liu
Technology Areas: Biotechnology / Diagnostics / Therapeutics
Impact Areas: Healthy Living
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Compact, Portable, Re-Configurable Unit for Making On-Demand Pharmaceutical Tablets

Technology / Case number: #19221
David Brancazio / Gregory Hammersmith / Juan Osorio Caicedo / Mohammad Azad / Allan S. Myerson
Technology Areas: Drug Delivery / Industrial Engineering & Automation
Impact Areas: Healthy Living
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Peptide-Targeted Layer-by-Layer Nanoparticle for Glioblastoma Treatment

Technology / Case number: #25659
Paula Hammond / Priya Ganesh / Andrew Pickering / Nicholas Lamson / Natalie Boehnke
Technology Areas: Chemicals & Materials / Drug Delivery / Sensing & Imaging / Therapeutics
Impact Areas: Healthy Living
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Conformable Ultrasound Face Patch for Cavitation Enhanced Transdermal

Technology / Case number: #24824TE
Canan Dagdeviren
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Ionizable Lipid OF-02 and its Use in mRNA Delivery

Technology / Case number: #17733
Daniel Anderson / Rebecca McClellan / Kevin Kauffman / Owen Fenton / Joseph Dorkin
Technology Areas: Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
License

Human Microbiome Clostridia-Derived Biosynthetic Enzymes/Pathways for the Biological Production of Natural and Non-Natural Fatty Acylated Compounds

Technology / Case number: #20961
Christopher Voigt / Fang-Yuan Chang
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living
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In Vitro and in Vivo Delivery of Complex Genetic Circuits up to 33kb Using Engineered HSV-1

Technology / Case number: #20746
Ron Weiss / Ross Jones / Jin Huh / Maria Hottelet Foley
Technology Areas: Diagnostics / Drug Delivery
Impact Areas: Healthy Living
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Phosphorylation-Based miRNA High Sensor

Technology / Case number: #19683
Ron Weiss / Ross Jones / Jin Huh
Technology Areas: Biotechnology / Diagnostics / Therapeutics
Impact Areas: Healthy Living
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A Signal Inverter Module for RNA Cleavers: Detecting and Evaluating miRNA, Ribozymes, and Ribonucleases

Technology / Case number: #19604
Ron Weiss / Breanna DiAndreth
Technology Areas: Biotechnology / Diagnostics / Therapeutics
Impact Areas: Healthy Living
License

New Genetic Circuit Topologies for High Performance Multi-Input MicroRNA Sensors for Classifying Living Cell State

Technology / Case number: #19534
Ron Weiss / Jin Huh
Technology Areas: Diagnostics / Therapeutics
Impact Areas: Healthy Living
License

Optimized Opsin Trafficking with Fluorescence-Dead Protein Fusions

Technology / Case number: #18783TE
Edward Stuart Boyden / Demian Park / Aimei Yang / Kiryl Piatkevich
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Novel Method to Correct Altered Synaptic Signaling in Autism and Intellectual Disability

Technology / Case number: #18383PHJ
Mark Bear / Robert Lefkowitz / Laura Stoppel / Benjamin Auerbach
Technology Areas: Therapeutics
Impact Areas: Healthy Living
License

Oligomeric Conjugates for siRNA Delivery and Glucose-Responsive Insulins

Technology / Case number: #15977J
Robert Langer / Rosemary Kanasty / Arturo Vegas / Daniel Anderson
Technology Areas: Diagnostics / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

Biodegradable Lipids and Formulations for Intramuscular and Systemic Delivery of mRNA

Technology / Case number: #25351J
Daniel Anderson / Kaelan Reed / Akash Gupta / Arnab Rudra
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

Layer-by-Layer Based Nanoparticles for Systemic Delivery Applications

Technology / Case number: #14680
Paula Hammond / Zhiyong Poon
Technology Areas: Chemicals & Materials / Computer Science / Drug Delivery
Impact Areas: Healthy Living
License

The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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