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Plk1 inhibitor and Microtubule Poison Dual Payload Antibody Drug Conjugates for the Treatment of Cancer

Technology / Case number: #26136
Michael Yaffe / Jesse C Patterson
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Utilizing a Strategic Blend of Block Copolymers to Control Particle Surface Charge for Enhanced Mucus Transport and Tissue Targeting

Technology / Case number: #25439J
Angela Belcher / Brian Wilson / Boris Sevarika / Robert Prud'homme / Corey Alfred Stevens / Katharina Ribbeck
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living
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Multi-Waveguide Beam Scanners and Scanning Pattern Methods

Technology / Case number: #26324J
Dirk R Englund / Matthew Zimmermann / Henry Wen
Technology Areas: Biotechnology / Electronics & Photonics / Energy & Distribution / Industrial Engineering & Automation
Impact Areas: Sustainable Future, Connected World
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Polymeric Core-Shell Particles for Pulsatile Release of HIV Vaccine

Technology / Case number: #26230
Robert Langer / Stacey Lin / Aki Gurram / Rishi Das / Amy Lee / Behnaz Eshaghi / Maria Kanelli / Ana Jaklenec
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Branched Poly(-amino esters) for the Delivery of Nucleic Acids

Technology / Case number: #20333JQ
Robert Langer / Gary Liu / James Byrne / Netra Kamat / Hyunjoon Kim / Daniel Reker / Grace Junyue Zhong / Ameya Kirtane / Yunhua Shi / Giovanni Traverso
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Amino Acid, Peptide, Polypeptide-Lipids (APPL) Derivatives and Uses Thereof

Technology / Case number: #14910Q
Robert Langer / Akinleye Alabi / Yunlong Zhang / Yizhou Dong / Yi Chen / Delai Chen / Arturo Vegas / Kevin Love / Daniel Anderson
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Patient-Specific Benchtop Beating Heart Simulator for Recreating Left Atrial Biomechanics and Hemodynamics for LAA Closure and HFpEF Intervention Testing

Technology / Case number: #25761
Ellen Roche / Manisha Singh / Keegan Mendez
Technology Areas: Biomaterials & Bioelectronics / Biotechnology
Impact Areas: Healthy Living
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Methods for Improving Statistical Power in Genetic Discovery by Incorporating Quality Control Flags

Technology / Case number: #25839P
Manolis Kellis / Yosuke Tanigawa
Technology Areas: Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Methods for Microbial Oil Overproduction from Cellulosic Materials

Technology / Case number: #15695
Gregory Stephanopoulos / Mitchell Tai
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Environmental Engineering
Impact Areas: Healthy Living, Sustainable Future
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Method for Quantitative Monitoring of In Vivo Tumor Oxygenation

Technology / Case number: #19207JQ
Michael Cima / Ehud Schmidt / Robert Cormack / Larissa Lee / Gregory Ekchian
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Strategy for Installing Hydrophobic Chains Plus Phosphorus Ligands onto MOFs

Technology / Case number: #25160
Mircea Dinca / Nathan Gin / Valiallah Hosseininasab
Technology Areas: Biotechnology / Chemicals & Materials / Industrial Engineering & Automation
Impact Areas: Healthy Living
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Reprogram the Genome of M13 Phage for Vaccination and Immunotherapy Applications

Technology / Case number: #25169
Angela Belcher / Shengnan Huang
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Transformer Stand to Sit Robot

Technology / Case number: #25883
Harry Asada / Emily Kamienski
Technology Areas: Biotechnology / Industrial Engineering & Automation
Impact Areas: Healthy Living
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Scaffold System for Microfluidic Tissue Chips

Technology / Case number: #25885
Linda Griffith / Matthew Johnson / Priyatanu Roy / David L Trumper
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living, Advanced Materials
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A Mechanical Underwater Soft Adhesion System for Kinetic Biosensing and Intelligent Targeted Drug Delivery

Technology / Case number: #26028J
Giovanni Traverso / Yubin Cai / Troy Ziliang Kang / Ming Zhao / Ameya Kirtane
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Bioinspired Soft Enteroscopic Robot for Facilitating Locomotion, Steering, and Intervention in the Deep Small Intestine

Technology / Case number: #26029J
Giovanni Traverso / Binbin Ying / Sahab Babaee / Mujtaba Jebran
Technology Areas: Biotechnology / Industrial Engineering & Automation
Impact Areas: Healthy Living
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Expression Constructs for One-Step Construction of Allogeneic CAR-NK Cells

Technology, Tangible Property / Case number: #26118J
Jianzhu Chen / Fuguo Liu / Rizwan Romee
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Connected World
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Hand Exoskeleton System for Data Collection

Technology / Case number: #26180
Edward Adelson / Arthur Hu / Haoshu Fang / Pulkit Agrawal / Branden Romero
Technology Areas: Biotechnology / Computer Science
Impact Areas: Healthy Living
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Using a Genetically Modified Human IPS Line to Screen for Drugs that Prevent or Treat Alzheimer's Disease

Technology / Case number: #26292P
Li-Huei Tsai / Masayuki Nakano / Matheus Victor / Leyla Akay / TaeHyun Kim
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Optical Device for Detection of an Agent (2)

Technology / Case number: #16125J
Anuradha Murthy Agarwal / Adam Kennedy / Darin Williams / Frank Jaworski / Juejun Hu
Technology Areas: Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living, Connected World
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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