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Rapid Droplet-Based Systems for Antibody Drug Discovery

Technology / Case number: #23890J
Brandon DeKosky / Shuyan Jin / Nicoleen Boyle / Ahmed Fahad / Cheng-yu Chung / Matias Gutierrez Gonzalez
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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High-throughput Electroporation Device

Technology / Case number: #21871
Cullen R. Buie / Sijie Chen / Po-Hsun Huang
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Industrial Engineering & Automation
Impact Areas: Healthy Living
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Multi-Targeted, Tunable, Sustained Delivery of Drugs and Other Payloads to Charged Avascular Tissues

Technology / Case number: #21303
Alan Grodzinsky / Yamini Krishnan
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Single Cell Super-Resolution Proteomics

Technology / Case number: #24088
Mark Harnett / Dimitra Vardalaki
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living, Uncharted Frontiers
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Targeting Dendritic Cell Lectins with Glycosylated Particles Containing TLR Ligands Facilitates Efficient Immune Responses

Technology / Case number: #24570J
Laura L Kiessling / Robert Hincapie / Mohammad Murshid Alam / M.G. Finn / Valerie Lensch
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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RNA-Loaded Lipid Nanoparticle (LNP)

Technology, Tangible Property / Case number: #24973H
Darrell J Irvine / B.j. Kim
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Composition and Methods to Generate Assymetric Bispecific Antibodies from a Single Cell Line

Technology / Case number: #17698
Ram Sasisekharan / Andrew Hatas / Eduardo Fleischer / Vidya Subramanian / Kannan Tharakaraman
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Amphiphilic Cisplatin Prodrug Nanoparticles for Co-Incorporation of Water-Insoluble Synergistic Small Molecules Chemotherapies and RNAi

Technology / Case number: #17774
Paiman Ghoroghchian / Ting Li / Ruogu Qi / Haihua Xiao
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Selective Metal-Mediated Arylation of Dichalcogenides in Biomolecules

Technology / Case number: #17814
Stephen Buchwald / Daniel Cohen / Chi Zhang / Bradley L. Pentelute
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Microfluidic Device for the 3D and Compartmentalized Coculture of Neuronal and Muscle Cells, with Functional Force Readout

Technology / Case number: #18042
Roger Kamm / Sebastien Uzel
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Persistent Carbene Monolayers on Silicon Substrates

Technology / Case number: #18755
Jeremiah A. Johnson / Aleksandr Zhukhovitskiy
Technology Areas: Chemicals & Materials / Drug Delivery / Sensing & Imaging
Impact Areas: Advanced Materials
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Platform for High-Resolution Genome Mapping

Technology / Case number: #19244
Rajeev Ram / Huaiyu Meng
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Electronics & Photonics
Impact Areas: Healthy Living
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Measuring Single-Cell Biophysical Properties by Acoustical Scattering in Microchannels

Technology / Case number: #19506
Scott Manalis / Joon Ho Kang / Selim Olcum
Technology Areas: Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Chiral Oligotriazoles with Precise Structures

Technology / Case number: #19866
Jeremiah A. Johnson / Yoshiki Shibuya / Hung Nguyen / Yivan Jiang
Technology Areas: Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living
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Implantable Active Coil-based Transducers (ImpACTs) for Minimally-Invasive Biophysical Imaging

Technology / Case number: #20183
Alan Pradip Jasanoff / Aviad Hai / Virginia Spanoudaki
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Drug Discovery and Research Tools / Electronics & Photonics
Impact Areas: Healthy Living
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An RNA Sequencing Method for Absolute Quantification of RNA Molecules

Technology / Case number: #20363
Peter C Dedon / Jennifer Hu / Bo Cao / Michael DeMott
Technology Areas: Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Functionalization of Protective Antigen by Chemical Conjugation

Technology / Case number: #20802
Bradley L. Pentelute / Zeyu Lu
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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A Micro Physiological Model for ALS

Technology / Case number: #20857
Roger Kamm / Tatsuya Osaki / Sebastien Uzel
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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A Platform for Continuous Directed Evolution in Human Cells

Technology / Case number: #19909
Matthew D. Shoulders / Samuel Hendel / Chet Berman / Christopher Moore / Louis Papa
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Concepts and Methods for Controlling Chemical Reaction Kinetics and Interaction Time in Large Systems

Technology / Case number: #18377
Kwanghun Chung / Jae Cho / Evan Murray
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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