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In Vitro and in Vivo Delivery of Complex Genetic Circuits up to 33kb Using Engineered HSV-1

Technology / Case number: #20746
Ron Weiss / Ross Jones / Jin Huh / Maria Hottelet Foley
Technology Areas: Diagnostics / Drug Delivery
Impact Areas: Healthy Living
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Oligomeric Conjugates for siRNA Delivery and Glucose-Responsive Insulins

Technology / Case number: #15977J
Robert Langer / Rosemary Kanasty / Arturo Vegas / Daniel Anderson
Technology Areas: Diagnostics / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Channel-less Drip Irrigation Emitter

Technology / Case number: #25861
Amos Winter / Julia Howarth / Aditya Avinash Ghodgaonkar
Technology Areas: Agriculture & Food / Environmental Engineering / Industrial Engineering & Automation
Impact Areas: Sustainable Future
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Biodegradable Lipids and Formulations for Intramuscular and Systemic Delivery of mRNA

Technology / Case number: #25351J
Daniel Anderson / Kaelan Reed / Akash Gupta / Arnab Rudra
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Layer-by-Layer Based Nanoparticles for Systemic Delivery Applications

Technology / Case number: #14680
Paula Hammond / Zhiyong Poon
Technology Areas: Chemicals & Materials / Computer Science / Drug Delivery
Impact Areas: Healthy Living
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Tunable Structure of Biodegradable Silk-Based Microcapsules for Soluble and Insoluble Payload Delivery

Technology / Case number: #23764J
Benedetto Marelli / Yagmur Yegin / Bernd Oschmann / Rupert Konradi / Ophelie Zeyons / Henning Urch / Pierre-Eric Millard / Muchun Liu
Technology Areas: Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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Sorption-based Atmospheric Water Harvesting Device

Technology / Case number: #23064J
Evelyn N. Wang / Omar Yaghi / Hiroyasu Furukawa / Eugene Kapustin / Sameer Rao / Ari Umans / Hyunho Kim / Sungwoo Yang / Shankar Narayan
Technology Areas: Environmental Engineering
Impact Areas: Sustainable Future
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Vibrating Ingestible BioElectronic Stimulator (VIBES)

Technology / Case number: #23759JQ
Robert Langer / Amro Alshareef / Shriya Sruthi Srinivasan / Giovanni Traverso
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Composite Anti-Fouling Coatings Designed via Full Spectral Hamaker Constant Minimization

Technology / Case number: #21606J
Michael Short / Robert Simpson / Max Carlson
Technology Areas: Chemicals & Materials / Energy & Distribution / Environmental Engineering
Impact Areas: Climate Stabilization, Sustainable Future
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Noise Recycling

Technology / Case number: #22102J
Muriel Medard / Alejandro Cohen / Amit Solomon / Kenneth Duffy
Technology Areas: Communication Systems / Computer Science / Environmental Engineering
Impact Areas: Sustainable Future, Connected World
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Reconfigurable Precast Concrete Construction System for Buildings Designed through Algorithmic Engineering with Inventory Constraints

Technology / Case number: #25018
Caitlin T Mueller / Pitipat Wongsittikan / Yanjun Liu / Keith Lee / Jenna Schnitzler / Inge Donovan
Technology Areas: Environmental Engineering / Industrial Engineering & Automation
Impact Areas: Sustainable Future
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Curbside-recyclable Products from Mono-material Polyethylene Fabrics With Polyethylene 3D Printed Features and Methods Thereof

Technology / Case number: #24436
Svetlana V Boriskina / Duo Xu / Leslie Yan / Volodymyr Korolovych
Technology Areas: Chemicals & Materials / Environmental Engineering
Impact Areas: Sustainable Future, Advanced Materials
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A Handheld Closed-Loop Automatic Insulin Delivery System

Technology / Case number: #22018J
Giovanni Traverso / Canchen Li / Erin Raftery / Sean You / Hen Wei Huang
Technology Areas: Biotechnology / Communication Systems / Drug Delivery
Impact Areas: Healthy Living
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Novel Ionizable Lipids Suitable For Lipid Nanoparticle Delivery of mRNA to Lung and Nasal Epithelium, As Well As Lung Endothelium

Technology / Case number: #23594Q
Daniel Anderson / Idris Raji / Jacob Witten / Allen Jiang / Luke Rhym
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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New Ionizable Lipid Library Suitable for Multiple Organ Targeting Derived From High Throughput Combinatorial Synthesis and Screening

Technology / Case number: #23406
Daniel Anderson / Idris Raji / Akiva Gordon / Bowen Li
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Enhancement of Lignocellulosic Fermentation in S. Cerevisiae by Combined Genetic Modulations and Media Supplementation

Technology / Case number: #21982WJ
Gerald Fink / Felix Lam / Gregory Stephanopoulos
Technology Areas: Biotechnology / Chemicals & Materials / Energy & Distribution / Environmental Engineering
Impact Areas: Sustainable Future
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Cellular Backpacks for Drug Delivery Across the Blood-Brain Barrier

Technology / Case number: #18547J
Robert Cohen / Natalya Klyachko / Yuling Zhao / Matthew Haney / Elena Batrakova / Roberta Polak / Michael F Rubner
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Devices, Methods and Systems for Recycling Combustion Ash

Technology / Case number: #22655J
Yet-Ming Chiang / Michael Wang / Sonia Zhang / Sophie Coppieters T Wallant / Leah Ellis / Venkat Viswanathan / Elsa Olivetti
Technology Areas: Environmental Engineering
Impact Areas: Sustainable Future
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Oleogel Drug Delivery Systems for Pediatric Applications

Technology / Case number: #22116J
Robert Langer / Christina Karavasili / Aniket Wahane / Ameya Kirtane / Giovanni Traverso
Technology Areas: Agriculture & Food / Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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Machine Learning for the Design of Cancer Vaccine Adjuvants

Technology / Case number: #21680J
Robert Langer / Netra Kamat / Hyunjoon Kim / Lewis Scott Jones / Daniel Reker / Ameya Kirtane / Giovanni Traverso
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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