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PROTAC Derivatives with Functional Handles for Chemical Conjugation/Modification

Technology / Case number: #20788J
Jeremiah A. Johnson / Aiden Wang / Michael Agius / Irene Ghobrial / Alexandre Detappe / Hung Nguyen / Yivan Jiang
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Use of Choline Supplementation as Therapy for APOE4-Related Disorders

Technology / Case number: #20957WPJ
Li-Huei Tsai / Greg Sienski / Priyanka Narayan / Julia Bonner / Yuan-Ta Lin
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Structures with Complex Geometries and Controlled Porosity in Micrometer to Meter Dimensions Produced at Large Scale

Technology / Case number: #21002J
Yoel Fink / Ian Tafel / Dena Shahriari / Zi Jie Gabriel Loke / Polina Anikeeva
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living, Advanced Materials
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Overcoming Emission Photon Scattering in Wide-Field Microscopy

Technology / Case number: #20164P
Peter So / Dushan Wadduwage / Balpreet Ahluwalia / Kalen Berry / Yi Xue / Jong Kang Park / Christopher Rowlands / Elly Nedivi
Technology Areas: Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living
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Advanced Architectures and Operating Principles for Electrochemical Neuro-Modulation

Technology / Case number: #20280J
Jongyoon Han / Matthew Flavin / Daniel Freeman
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living
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Gastric-Resident Devices for Gram-level Drug Delivery

Technology / Case number: #20379JQ
Robert Langer / Daniel Minahan / Taylor Bensel / Malvika Verma / Tyler Grant / Andrew Bellinger / Giovanni Traverso
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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1. Methods for in Vitro Evolution of Constructs Derived from Viruses. 2. Five Mutations Derived from the in Vitro Evolution. 3. Seventeen constructs from the five mutations.

Technology / Case number: #20395H
Darrell J Irvine / Yingzhong Li / Ron Weiss
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Locally Delivered Therapeutics and Combinations for Expedited Passage of Urinary Stones

Technology / Case number: #19454JQ
Michael Cima / Brian Eisner / Xiang Li
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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A Multimodal Metric for Tracking Nociception Under Anesthesia

Technology / Case number: #20522J
Emery N Brown / Sandya Subramanian / Riccardo Barbieri
Technology Areas: Biotechnology / Computer Science
Impact Areas: Healthy Living
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Leveraging Device-arterial Coupling to Determine Cardiac and Vascular State

Technology / Case number: #20558J
Elazer R Edelman / Ahmad El Katerji / Quing Tan / Noam Josephy / Sonya Sanat Bhavsar / Steven Keller / Brian Chang
Technology Areas: Biotechnology
Impact Areas: Healthy Living
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Soft Neuroprosthetic Hand

Technology / Case number: #22255J
Xuanhe Zhao / Guoying Gu / Xiangyang Zhu / Haipeng Xu / Ningbin Zhang / Shaoting Lin
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living
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Centrifugal Microfluidic Platforms for Cell Pairing and Fusion

Technology / Case number: #22275J
Joel Voldman / Sergio Martínez-Chapa / MohammadMahdi Aeinhvand
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Remoldable and Self-Healing Thermoset Materials

Technology / Case number: #22307
Jeremiah A. Johnson / Samantha Kristufek / Christopher Brown / Keith Husted / Peyton Shieh
Technology Areas: Chemicals & Materials
Impact Areas: Advanced Materials
License

Control Replication and Transcription of Self-Replicating RNA in Responses to Small Molecule TMP

Technology / Case number: #22331H
Darrell J Irvine / Parisa Yousefpour / Jan Lonzaric / Yingzhong Li / Ron Weiss
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Catheter for Intracardiac 3D Bioprinting

Technology / Case number: #22338J
Brett E Bouma / Markus Horvath / Sophie Wang / Milen Shishkov / Victor Damptey / Connor Verheyen / Keegan Mendez / Ellen Roche / Sebastien Uzel / Jennifer Lewis
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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High-Throughput Expansion Microscopy

Technology / Case number: #22339
Laurie Boyer / Catherine Della Santina / John Day / Alexander Auld / Pema Maretich / Edward Stuart Boyden
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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M13 Bacteriophage with a High Cysteine Content and Genetically Engineerable Hydrogels

Technology / Case number: #22369
Angela Belcher / Nimrod Heldman / William Records
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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Characterization and Utilization of a Subgenomic Promoter Mutant Library for Tuning Expression of Multiple Transgenes from Alphavirus Replicons

Technology / Case number: #21309
Ron Weiss / Jin Huh
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Design of an Externally Modulated Variable Excitation Raman Spectrometer

Technology / Case number: #21321
Ian Hunter / Michael Zervas
Technology Areas: Electronics & Photonics / Sensing & Imaging
Impact Areas: Healthy Living
License

MicroRNA-based Logic Gates that Do Not Use Exogenous Proteins

Technology / Case number: #21334
Ron Weiss / Giulio Alighieri
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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