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An Efficient Bioconjugation Technology for Site-Selective Covalent Modification of Antibodies using an Engineered Affinity Peptide

Technology / Case number: #25358
Bradley L. Pentelute / Katsushi Kitahara / Aurelie Rondon / Heemal Dhanjee / Jacob Rodriguez / Andrei Loas
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Fabrication of Polymeric Microneedles with Hollow and Porous Tips via a Simple Micromolding Process Assisted by Ionic Salts

Technology / Case number: #24093
Benedetto Marelli / Doyoon Kim
Technology Areas: Agriculture & Food / Chemicals & Materials
Impact Areas: Advanced Materials
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A Multi-Pathway Reporter System that Interrogates Repair of DNA Double-Strand Breaks with Applications for Diagnosis and Therapeutic Treatment of Cancer and Neurodegenerative Diseases

Technology / Case number: #25444
Michael Yaffe / Alex Kruswick
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Epoxides for Multimodal Detection of Biomolecules by Expansion Microscopy

Technology / Case number: #24137HM
Edward Stuart Boyden / Yi Cui
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living
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Compositions of Polyhydroxylated Benzophenones and Methods of Treatment of Neurodegenerative Disorders

Technology / Case number: #17855PJQ
Li-Huei Tsai / Ping-Chieh Pao / Debasis Patnaik / Stephen Haggarty
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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  • Alzheimer's Therapeutics
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Small Molecules Suppressors of APOE Gene Expression and Cerebral Vascular Amyloid Pathology

Technology / Case number: #22991P
Li-Huei Tsai / Joel Blanchard
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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  • Alzheimer's Therapeutics
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Small Molecules to Improve Myelination in Alzheimer's Disease and APOE4 Carriers

Technology / Case number: #23168P
Li-Huei Tsai / Matheus Victor / Audrey Effenberger / Djuna von Maydell / Leyla Akay / Jose Davila Velderrain / Joel Blanchard / Manolis Kellis
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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  • Alzheimer's Therapeutics
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Using Anti-Inflammatory Drugs To Enhance The Neuroprotective Effects Of Non-Invasive Gamma Stimulation

Technology / Case number: #23402P
Li-Huei Tsai / Julia Bonner / Vanesa Fernandez Avalos / Chinnakkaruppan Adaikkan
Technology Areas: Sensing & Imaging / Therapeutics
Impact Areas: Healthy Living
Labels
  • Alzheimer's Therapeutics
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Lipid Nanoparticles for Drug Delivery to Microglia in the Brain

Technology / Case number: #23156P
Robert Langer / William Ralvenius / Julia Bonner / Jason Andresen / Joel Blanchard / Owen Fenton / Li-Huei Tsai
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
Labels
  • Alzheimer's Therapeutics
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Multicellular Integrated Brain Tissue for Investigation and Therapeutic Discovery in Neurological Diseases

Technology / Case number: #22618P
Robert Langer / Adele Bubnys / Alice Stanton / Joel Blanchard / Li-Huei Tsai
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Healthy Living
Labels
  • Alzheimer's Therapeutics
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Use of Choline Supplementation as Therapy for APOE4-Related Disorders

Technology / Case number: #20957WPJ
Li-Huei Tsai / Greg Sienski / Priyanka Narayan / Julia Bonner / Yuan-Ta Lin
Technology Areas: Therapeutics
Impact Areas: Healthy Living
Labels
  • Alzheimer's Therapeutics
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Adhesive, Injectable Hydrogels for Local Therapy Delivery to Brain Tumors

Exclusively Licensed Technology / Case number: #24170JQ
Natalie Artzi / Dahis Daniel / Michelle Dion
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living

Intrinsically Stretchable Microelectronic Fibers and Their Assemblies as Multifunctional Bioelectronic Interfaces for Whole Organs

Technology / Case number: #24178
Polina Anikeeva / Rajib Mondal / Atharva Sahasrabudhe
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living, Uncharted Frontiers, Advanced Materials
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Universal Redirection of Chimeric Antigen Receptor T Cells Against Solid Tumors via Tumor Cell Membrane-Inserting CAR Ligands

Technology / Case number: #24270H
Darrell J Irvine / Alexander Hostetler / Laura Chen / Angela Zhang
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Synthesis of Potent Epidithiodiketopiperazines Designed for Facile Derivatization

Technology / Case number: #21469
Mo Movassaghi / Tony Scott / Chase Olsson / Jaime Cheah / Joshua Payette
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Split Intein-based Selection for Modified Peptide Binders to SARS-CoV-2 Spike Protein

Exclusively Licensed Technology / Case number: #22502
Christopher Voigt / Andrew King / Emerson Glassey
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living

Compounds, Compositions, and Methods of Macrocyclic Depsipeptide Antibiotics

Technology / Case number: #23104
Mo Movassaghi / Kyan D'Angelo / Carly Schissel / Bradley L. Pentelute
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Multi-Input miRNA Sensing with Constitutive ERNs to Regulate Multi-Output Gene Expression in Mammalian Cells

Exclusively Licensed Technology / Case number: #23123
Ron Weiss / Lei Wang / Wenlong Xu / Erez Pery / Deepak Mishra
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living

High-Resolution Long-Term Wearable Ultrasound Devices

Exclusively Licensed Technology / Case number: #24013
Xuanhe Zhao / Chonghe Wang / Xiaoyu Chen
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living

High Throughput Stochastic Bio-Molecular Sensor

Exclusively Licensed Technology / Case number: #24610
Ashwin Gopinath / Swathi Manda
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Diagnostics
Impact Areas: Healthy Living

The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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