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1. Methods for in Vitro Evolution of Constructs Derived from Viruses. 2. Five Mutations Derived from the in Vitro Evolution. 3. Seventeen constructs from the five mutations.

Technology / Case number: #20395H
Ron Weiss / Yingzhong Li / Darrell Irvine
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Interfacial Bioconjugation on Emulsion Droplets

Technology / Case number: #20314
Qifan Zhang / Timothy Swager
Technology Areas: Chemicals & Materials / Drug Delivery / Sensing & Imaging
Impact Areas: Advanced Materials
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Antibody Mediated Delivery of Antigen to B Cell Follicles for Enhanced Humoral Response

Technology / Case number: #24727H
Aereas Aung / Darrell Irvine
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Multi-Targeted, Tunable, Sustained Delivery of Drugs and Other Payloads to Charged Avascular Tissues

Technology / Case number: #21303
Yamini Krishnan / Alan Grodzinsky
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Targeting Dendritic Cell Lectins with Glycosylated Particles Containing TLR Ligands Facilitates Efficient Immune Responses

Technology / Case number: #24570J
Laura Kiessling / Valerie Lensch / M.G. Finn / Mohammad Murshid Alam / Robert Hincapie
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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RNA-Loaded Lipid Nanoparticle (LNP)

Technology, Tangible Property / Case number: #24973H
Byungji Kim / Darrell Irvine
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Nanoparticle Conjugates of Highly Potent Toxins

Technology / Case number: #19222
Paiman Ghoroghchian / Ruogu Qi
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Persistent Carbene Monolayers on Silicon Substrates

Technology / Case number: #18755
Jeremiah Johnson / Aleksandr Zhukhovitskiy
Technology Areas: Chemicals & Materials / Drug Delivery / Sensing & Imaging
Impact Areas: Advanced Materials
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DNA Virus Launched RNA Replicon System (VREP) for Prolonged and High Level Expression of Transgenes with High Precision Controls

Technology / Case number: #20866
Ron Weiss / Jacob Becraft / Jin Huh
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Chiral Oligotriazoles with Precise Structures

Technology / Case number: #19866
Jeremiah Johnson / Yivan Jiang / Hung Nguyen / Yoshiki Shibuya
Technology Areas: Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living
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Protein Corona Phase Molecular Recognition (CoPhMoRe)

Technology / Case number: #18316
Michael Strano / Gili Bisker Raviv
Technology Areas: Biotechnology / Drug Delivery
Impact Areas: Healthy Living
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Engineered Phagemids for Non-Lytic, Targeted Antibacterial Technologies

Technology / Case number: #18186HJY
James Collins / Russell-John Krom / Prerna Bhargava / Michael Lobritz
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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PNA Amphiphile Adjuvant Delivery Vehicles

Technology / Case number: #18878H
Eric Dane / Darrell Irvine
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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M13 Phage Assembly System for Optimal Blood Trafficking, Tumor Penetration, and Passage Across the Blood Brain Barrier

Technology / Case number: #19438
Uyanga Tsedev / Fred Lam / Angela Belcher
Technology Areas: Drug Delivery / Sensing & Imaging / Therapeutics
Impact Areas: Healthy Living
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Manufacture of Thermo-Responsive Hydrogel Composing of Drug-Nanocapsule for Sustainable Release of Ibuprofen, Ofloxacin and Dexamethasone

Technology / Case number: #18561
Jeremiah Johnson / Qixian Chen / Farrukh Vohidov
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Layer-by-Layer Nanoparticles for Cytokine Therapy in Cancer Treatment

Technology / Case number: #20027H
Erik Dreaden / Mariane Melo / Antonio Barberio / Santiago Correa Echavarria / Talar Tokatlian / Darrell Irvine / Paula Hammond
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Dendrimer Drug Conjugates for Sustained Intra-Articular Delivery

Technology / Case number: #19214
Brett Geiger / Paula Hammond
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Removal of Ruthenium-Initiator from Brush-Arm Star Polymers (BASPs) via Core-to-Surface Ring-Opening Methathesis Polymerization (ROMP)

Technology / Case number: #19525
Jeremiah Johnson / Matthew Golder
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Manuka Honey Microneedle: Methods and Uses

Technology / Case number: #21539
Galit Frydman / David Olaleye / Illina Yang / Damodaran Annamalai
Technology Areas: Biotechnology / Drug Delivery
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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