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Nanosensors for Detecting and Imaging of Cancer Metastasis

Technology / Case number: #20490H
Sangeeta Bhatia / Liang Hao
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics
Impact Areas: Healthy Living
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Immunostimulatory Nanoparticle Adjuvants

Non-Exclusively Licensed Technology / Case number: #20798HJ
Darrell J Irvine / Shane Crotty / Yu Kato / Murillo Silva
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Uses of Amphiphiles in Immune Cell Therapy and Compositions Therefore

Technology / Case number: #21411H
Darrell J Irvine / Peter DeMuth
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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STING Agonist Delivery by Lipid Nanodiscs for Tumor Immunotherapy

Technology / Case number: #21441HJ
Darrell J Irvine / Masanori Okaniwa / Eric Dane
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Intra-Tumoral Injection of Cytotoxic Chemotherapy-Treated Tumor Cells in Combination with Systemic Immune Checkpoint Blockade for Cancer Treatment

Technology / Case number: #21498H
Darrell J Irvine / Lauren Milling / Ganapathy Sriram / Michael Yaffe
Technology Areas: Diagnostics / Therapeutics
Impact Areas: Healthy Living
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Multiplexed in Vivo Disease Sensing with Nucleic Acid-Barcoded Reporters enabling CRISPR-Cas-based Detection

Technology / Case number: #21723H
Sangeeta Bhatia / Chayanon Ngambenjawong / Renee Zhao / Liang Hao
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics
Impact Areas: Healthy Living
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Melanin-Peptide-based Photonic Materials

Technology / Case number: #22001
Christopher Voigt / Disheng Lee
Technology Areas: Chemicals & Materials / Electronics & Photonics
Impact Areas: Sustainable Future, Advanced Materials
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Split Intein-based Selection for Modified Peptide Binders to SARS-CoV-2 Spike Protein

Technology / Case number: #22502
Christopher Voigt / Andrew King / Emerson Glassey
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Universal Redirection of Chimeric Antigen Receptor T Cells Against Solid Tumors via Tumor Cell Membrane-Inserting CAR Ligands

Technology / Case number: #24270H
Darrell J Irvine / Alexander Hostetler / Laura Chen / Angela Zhang
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Compositions for the Conditional Delivery of Macromolecules and Combination Therapeutics

Technology / Case number: #24492H
Sangeeta Bhatia / Qian Zhong / Edward Tan / Chayanon Ngambenjawong
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Controlled Lipid Self-Assembly for Scalable Manufacturing of Next-Generation Immune Stimulating Complexes

Technology / Case number: #24582H
Darrell J Irvine / Ivan Pires / Paula Hammond
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Ultrafast Single-Step High-Density Conjugation of Quantum Dots and Rods with 2D Lattice Templated Array Alignment using DNA Origami

Technology / Case number: #24671
Mark Bathe / Xin Luo / Chi Chen / Rob Macfarlane
Technology Areas: Chemicals & Materials / Electronics & Photonics
Impact Areas: Advanced Materials
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Modulating Oncogenic Transcriptional Dysregulation with Small Molecule Chimeric Degraders of Cyclin-Dependent Kinase 9

Technology / Case number: #24831
Angela Koehler / Keisuke Motoyama / Mohammed Toure
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Intracellular Molecular Recording and Memory via Protein Self-Assembly

Technology / Case number: #23746HPM
Edward Stuart Boyden / Changyang Linghu
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Peptide-Encoded Libraries of Small Molecules for De Novo Drug Discovery

Technology / Case number: #23712
Stephen Buchwald / Simon Roessler / Nathalie Grob / Bradley L. Pentelute
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Single-Cell Density as A Biomarker for Drug Sensitivity

Technology / Case number: #23741J
Scott Manalis / Kin-Hoe Chow / Sarah Ishamuddin / Teemu Miettinen / Weida Wu / Keith Ligon
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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High-Throughput and High-Precision Measurement of Single-Cell Density

Technology / Case number: #23740
Scott Manalis / Teemu Miettinen / Weida Wu
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Multifunctional Microelectronics Fibers as Implantable Bioelectronic Interfaces for Central and Peripheral Neuromodulation

Exclusively Licensed Technology / Case number: #23751JQ
Polina Anikeeva / Diego Bohórquez / Laura Rupprecht / Atharva Sahasrabudhe / Tural Khudiyev
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living

DNA-Dye Assembly Based Single-Molecule Fluorescence Lifetime Imaging Probes

Technology / Case number: #23780
Mark Bathe / Jiajia Guo / Gabriela Schlau-Cohen / Xiao Wang / Stephanie Hart
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics
Impact Areas: Healthy Living
License

Activity-based Cell Sorting

Technology / Case number: #23765HJ
Sangeeta Bhatia / Ava Soleimany / Jesse Kirkpatrick
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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