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Hardware Models of Biochemical Reaction Networks

Technology / Case number: #13076
Rahul Sarpeshkar / Soumyajit Mandal
Technology Areas: Biotechnology / Computer Science
Impact Areas: Healthy Living
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Seqwell Ancillary Tools and Assays Including StimSeq and Spatial Barcoding

Technology / Case number: #19508
J. Christopher Love / Marc Wadsworth / Travis Hughes / Alex Shalek / Todd Gierahn
Technology Areas: Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Altered DNA Repair Pathway Engagement by Engineered CRISPR-Cas9 Nucleases

Technology / Case number: #23588
Robert Langer / Vikash Pal Singh Chauhan / Phillip Sharp
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Methods for Microbial Oil Overproduction from Cellulosic Materials

Technology / Case number: #15695
Gregory Stephanopoulos / Mitchell Tai
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Environmental Engineering
Impact Areas: Healthy Living, Sustainable Future
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Colloidal Hydrogel Particles with tunable Chemistry, Geometry, and Flexibility

Technology / Case number: #13461J
Mehmet Toner / Ramin Haghgooie / Daniel Pregibon / Patrick Doyle
Technology Areas: Chemicals & Materials / Computer Science
Impact Areas: Healthy Living
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Programmable Addition Via Site-Specific Targeting Elements (PASTE)

Technology / Case number: #22225
Omar Abudayyeh / Jonathan S. Gootenberg
Technology Areas: Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Discovery and Engineering of Novel Integrases for High-Efficiency Gene Integration

Technology / Case number: #23554
Omar Abudayyeh / Justin Lim / Lukas Villiger / Jonathan S. Gootenberg
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Methods for Microbial Oil Overproduction via Amplification of the Biosynthetic and Sequestration Pathways Individually or in Combination

Technology / Case number: #15152
Gregory Stephanopoulos / Sagar Chakraborty / Mitchell Tai
Technology Areas: Biotechnology / Chemicals & Materials / Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Translocation of Non-Natural Chemical Entities Through Anthrax Protective Antigen Pore

Technology / Case number: #15639J
Bradley L. Pentelute / R. Collier / Gizem Akcay / Jingjing Ling / Amy Rabideau / Xiaoli Liao
Technology Areas: Computer Science / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Distinct Gene Systems Mediating Activity-Dependent Plasticity in Visual Cortex

Technology / Case number: #11841P
Mriganka Sur / Gabriel Kreiman / Daniela Tropea / Shayan Mukherjee / Alvin Lyckman
Technology Areas: Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Oscillating Cell Culture Bioreactor

Technology / Case number: #12301
Lisa Freed / Matteo Moretti / Robert Langer
Technology Areas: Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Glucose Valve and Other Metabolite Valves

Technology / Case number: #12369
Tae Moon / Kevin Solomon / Kristala L Jones Prather
Technology Areas: Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Reverse Micelle Nanoprecipitation: A Method for Encapsulating Nucleic Acids in Biodegradable Polymers

Technology / Case number: #12561J
Robert Langer / Liangfang Zhang / Aleksandar Radovic-Moreno / Omid Farokhzad
Technology Areas: Chemicals & Materials / Computer Science / Electronics & Photonics
Impact Areas: Healthy Living, Advanced Materials
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Olfactory Receptor-Based Devices

Technology / Case number: #12776TE
Shuguang Zhang / Liselotte Kaiser / Joanke (Johanna) Bikker Graveland / Brian Cook / Andreas Mershin / Manu Prakash / David Kong / Yael Maguire
Technology Areas: Biotechnology / Chemicals & Materials / Computer Science / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Transcriptional Engineering of Lactobacillus for Improved Lactic Acid Tolerance and Productivity at Low pH

Technology / Case number: #12783
Gregory Stephanopoulos / Daniel Klein-Marcuschamer
Technology Areas: Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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An Information-Theoretic Approach for Analyzing Chromatin State Models

Technology / Case number: #17666
Manolis Kellis / Wouter Meuleman
Technology Areas: Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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CD80 is a Biomarker of p53 Activity and a Target for Cancer Therapy

Technology / Case number: #15386H
Tyler Jacks / Leah Schmidt / David Feldser
Technology Areas: Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Extension of a Finite Element Framework for Calculation of DNA Nanostructure Solution Shape, Mechanical, and Optical Properties

Technology / Case number: #16421
Klaus-Jurgen Bathe / Oskar Hallatschek / Etienne Boulais / Reza Sharifi Sedeh / Lun Yang / Keyao Pan / Matthew Adendorff / Do-Nyun Kim / Mark Bathe
Technology Areas: Computer Science
Impact Areas: Healthy Living
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Normalization Correction for Inter-Detector Scatter Enhanced Positron Emission Tomography

Technology / Case number: #16136
Shivang Dave / Joaquin Herraiz / Eduardo Lage / Vicente Parot
Technology Areas: Computer Science / Sensing & Imaging
Impact Areas: Healthy Living
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Methods for Increasing Safety of Embryonic Stem Cells

Technology / Case number: #13769
Clark Colton / Jeffrey Millman
Technology Areas: Drug Discovery and Research Tools
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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