Programmable Addition Via Site-Specific Targeting Elements (PASTE)
Invention type: Technology
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Case number: #22225
This disclosure provides systems, methods, and compositions for site-specific genetic engineering using Programmable Addition via Site-Specific Targeting Elements (PASTE). PASTE comprises the addition of an integration site into a target genome followed by the insertion of one or more genes of interest or one or more nucleic acid sequences of interest at the site. PASTE combines gene editing technologies and integrase technologies to achieve unidirectional incorporation of genes in a genome for the treatment of diseases and diagnosis of disease.
Researchers
Omar Abudayyeh
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Jonathan S. Gootenberg
Technology Areas: Computer Science: Bioinformatics / Drug Discovery and Research Tools: Genomics & Proteomics
Impact Areas: Healthy Living
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systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste)
United States of America | Granted | 11,572,556 -
systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste)
United States of America | Granted | 11,827,881 -
systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste)
Australia | Pending -
systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste)
Canada | Published application -
systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste)
China | Published application -
systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste)
European Patent Convention | Published application -
systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste)
Japan | Published application -
systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste)
Korea (south) | Published application -
systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste)
Mexico | Pending -
systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste)
New Zealand | Pending -
systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste)
Singapore | Granted | 11,202,302,249 -
systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste)
United States of America | Granted | 11,834,658 -
systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste)
United States of America | Granted | 11,952,571 -
systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste)
United States of America | Granted | 12,195,733 -
systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste)
Hong Kong | Published application -
systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste)
Singapore | Pending -
systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste)
United States of America | Pending
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