Ultrasound-Mediated Gastrointestinal Drug Delivery

*This technology is related to case #19050

Apparatus, kits, and methods for administering a substance are presented. A device for administering a substance includes an elongated body having a proximal end and a distal end, the elongated body defining an internal chamber extending between the proximal end and the distal end to direct the substance to the distal end, the distal end to connect with a tip, the tip to be at least partially inserted into an orifice of a body lumen of a subject, the tip having a shape configured to reduce leakage of the substance from the orifice upon the at least partial insertion. The tip includes an opening to pass the substance from the internal chamber into the body lumen; and a transducer to emit an ultrasound wave from the tip into the body lumen, thereby administering the substance to tissue in the body lumen.

Researchers

William Brugge / Avraham Schroeder / Carlo Giovanni Traverso / Baris Polat / Carl Schoellhammer / Robert Langer / Edmundo Blankschtein

Departments: Department of Mechanical Engineering, Office of the Institute Professors, Department of Chemical Engineering
Technology Areas: Drug Delivery: Microparticles & Nanoparticles / Therapeutics: Regenerative Medicine
Impact Areas: Healthy Living

  • systems, apparatus, and methods for administering a substance
    Canada | Published application
  • systems, apparatus, and methods for administering a substance
    Brazil | Granted | 112,017,021,561
  • systems, apparatus, and methods for administering a substance
    United States of America | Granted | 11,185,626
  • systems, apparatus, and methods for administering a substance
    Israel | Granted | 254,893
  • systems, apparatus, and methods for administering a substance
    China | Granted | 0
  • systems, apparatus, and methods for administering a substance
    European Patent Convention | Granted | 3,280,483
  • systems, apparatus, and methods for administering a substance
    Japan | Granted | 6,727,287
  • systems, apparatus, and methods for administering a substance
    Mexico | Granted | 393,433
  • systems, apparatus, and assembling method thereof for administering a substance
    Japan | Granted | 6,878,656
  • systems, apparatus, and assembling method thereof for administering a substance
    Japan | Granted | 7,114,777
  • systems, apparatus, and assembling method thereof for administering a substance
    Israel | Granted | 283,343
  • systems, apparatus, and methods for administering a substance
    United States of America | Published application
  • systems, apparatus, and assembling method thereof for administering a substance
    Japan | Granted | 7,466,594
  • systems, apparatus, and methods for administering a substance
    Germany | Granted | 3,280,483
  • systems, apparatus, and methods for administering a substance
    France | Granted | 3,280,483
  • systems, apparatus, and methods for administering a substance
    United Kingdom | Granted | 3,280,483
  • systems, apparatus, and methods for administering a substance
    European Patent Convention | Published application
  • systems, apparatus, and methods for administering a substance
    Spain | Granted | 3,280,483
  • systems, apparatus, and methods for administering a substance
    Italy | Granted | 3,280,483

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