High-Throughput Mutagenesis and Screening of Phage Libraries with Altered Biological Functions

 

This invention presents novel synthetic bacteriophages and compositions, offering methods for their production and therapeutic uses. With the escalating challenge of drug-resistant bacterial infections, these synthetic bacteriophages address limitations in antibiotic research by providing an alternative therapy approach. By engineering phages with altered host ranges, the technology allows for the rapid evolution of combinatorial phage libraries, surpassing the limitations of natural phage evolution and offering a powerful solution for treating bacterial infections and delaying the evolution of bacterial strains.

Researchers

Timothy K Lu / Sebastien Lemire / Andrew Yang / Kevin Yehl

Departments: Department of Biological Engineering
Technology Areas: Biotechnology: Biomanufacturing, Biomedical Devices & Systems, Synthetic Biology / Drug Discovery and Research Tools: Genomics & Proteomics
Impact Areas: Healthy Living

  • synthetic bacteriophages and bacteriophage compositions
    United States of America | Granted | 10,626,394
  • synthetic bacteriophages and bacteriophage compositions
    United States of America | Granted | 11,091,762

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