This technology applies to long-term DNA storage and rapid retrieval, with applications in random access memory (RAM) using packaged DNA assemblies that encode information in their sequence with separate molecular tags for rapid retrieval.
This invention involves methods of storing, processing, and selectively retrieving information encoded within sequence-controlled polymer barcoded nanoparticles. The Inventors implement DNA memory storage in DNA origami, structured DNA objects, and encapsulated DNA memory, which physically associate into memory blocks with unique ID tags. This allows for rapid retrieval of large-scale memory blocks using associative memory and Boolean logic, reducing by orders of magnitude the read-out time required during DNA sequencing, while simultaneously enabling archival storage of the data. Optical barcoding of DNA memory packets on either DNA structures or encapsulated DNA memory enables rapid sorting of molecularly-encoded information exceeding 100 Mb/s. Additional biochemical barcodes narrows subsequent data search using algorithmic sorting.
DNA memory storage will revolutionize our ability to store archival information on the exabyte scale, not met by any existing archival memory storage technology.
- Massive storage capacity
- Very little energy required for maintenance
- Rapid retrieval of random access memory including algorithmic sorting
- Rapid retrieval of large-scale memory