Scott Manalis

David H. Koch (1962) Professor in Engineering

Department
Department of Biological Engineering
Technology Areas
Biotechnology: Sensors & Monitoring, Biomedical Devices & Systems, Cell Separation / Drug Discovery and Research Tools: Cell Interrogation, Cell Culture, Cell Lines & Organoids / Sensing & Imaging: Acoustics, Chemical & Radiation Sensing / Diagnostics: Assays

Developing techniques and instrumentation for single cell analysis and cancer research

Background and Experience

Scott Manalis is the David H. Koch (1962) Professor of Engineering and faculty member in the departments of biological and mechanical engineering at MIT. He currently serves as Associate Department Head in the Department of Biological Engineering.

Dr. Manalis' laboratory develops quantitative and real-time techniques for single cell analysis, using conventional approaches to fabricate novel fluidic devices, and exploit the unique physical properties associated with micro- and nanoscale dimensions for developing precision measurement methods.

In cancer, the lab is interested in creating functional assays for precision medicine. They are developing new technology platforms for predicting therapeutic response in which biophysical properties of individual tumor cells are measured in response to ex vivo treatment in a broad range of tumor types, including leukemias, glioblastoma, colon and pancreatic cancers.

Professor Manalis received a BS in physics from the University of California, Santa Barbara, and a PhD in applied physics from Stanford University. Dr. Manalis is a founder of two companies (Travera and Affinity Biosensors) that utilize the suspended microchannel resonator for weighing single cells.

Technologies

Method and Apparatus for High Throughput Diagnosis of Diseased Cells With Microchannel Devices

Technology / Case number: #11937
Subra Suresh / Ken Babcock / Thomas Burg / Scott Manalis
Technology Areas: Biotechnology / Diagnostics
Impact Areas: Healthy Living
License

Liquid Exchange and Positioning of Cellular Entities in a Liquid-air Interface

Technology / Case number: #24928J
Linda Griffith / Joseph Doyle / Haidong Feng / Georgios Katsikis / Scott Manalis
Technology Areas: Biotechnology
Labels
  • Women's Health
License

Flow Cytometry with Mass Sensitive Readout

Technology / Case number: #12273J
Scott Manalis / Ken Babcock / Michel Godin / Thomas Burg
Technology Areas: Biotechnology / Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living
License

High-Throughput and High-Precision Measurement of Single-Cell Density

Technology / Case number: #23740
Scott Manalis / Teemu Miettinen / Weida Wu
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
License

Single-Cell Density as A Biomarker for Drug Sensitivity

Technology / Case number: #23741J
Scott Manalis / Kin-Hoe Chow / Sarah Ishamuddin / Teemu Miettinen / Weida Wu / Keith Ligon
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
License

TRAV-007 (Genome Sequencing) 62/790,799

Technology / Case number: #22143J
Scott Manalis / Keith Ligon / Mark Stevens / Robert Kimmerling
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
License

TRAV-005 (Needles) 62/795,857

Technology / Case number: #22144J
Scott Manalis / David Weinstock / Robert Kimmerling / Selim Olcum
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
License

Measuring Single-Cell Biophysical Properties by Acoustical Scattering in Microchannels

Technology / Case number: #19506
Scott Manalis / Joon Ho Kang / Selim Olcum
Technology Areas: Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
License

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