Sangeeta Bhatia

John and Dorthy Wilson Professor

Department
Health Sciences and Technology Program
Technology Areas
Chemicals & Materials: Nanotechnology & Nanomaterials, Polymers, Composites, Catalysis & Synthesis / Drug Delivery: Microparticles & Nanoparticles / Therapeutics: Proteins & Antibodies, Small Molecules, Nucleic Acids, Cell Based Therapy, Regenerative Medicine / Biotechnology: Sensors & Monitoring, Cell Separation, Synthetic Biology, DNA & RNA Editing, Biomedical Devices & Systems / Diagnostics: Imaging Agents, Assays / Drug Discovery and Research Tools: Cell Interrogation / Sensing & Imaging: Chemical & Radiation Sensing, Optical Sensing / Biomaterials & Bioelectronics: Health Monitoring
Impact Areas

Integrating tissue engineering, nanotechnology, and microfabrication to create innovative liver models, diagnostic tools, and regenerative medicine strategies.

Background and Experience

The Bhatia Laboratory engineers micro and nanotechnologies, also called “tiny technologies,” to address complex challenges in human health ranging from cancer to liver disease and acquired infections. Operating at the interface of living and synthetic systems, the Bhatia group uses these miniaturization tools to improve areas of medicine including diagnostics, drug delivery, tissue regeneration, and disease modeling. In cancer, Bhatia’s multidisciplinary team develops tools for use in diagnostics and detection, and in precision therapeutics to specifically target tumors. Nanosensors designed by the Bhatia team are capable of detecting and profiling very early-stage tumors, and can be analyzed via a simple urine test. The same technology may also yield insights into a tumor’s response to certain therapies. The Bhatia Lab has also created human microlivers, which model human drug metabolism, liver disease, and interaction with pathogens.

Sangeeta Bhatia earned her BS at Brown University, followed by an MS in Mechanical Engineering at MIT, a PhD in Biomedical Engineering at the Harvard-MIT Division of Health Sciences and Technology, and an MD at Harvard Medical School. Prior to her appointment at MIT, Bhatia held a tenured position at UCSD. She and her trainees have launched multiple biotechnology companies to improve human health. 

Awards and Honors

  • Overseas Fellow of the Australian Academy of Technological Sciences and Engineering (FTSE)  | 2023
  • Othmer Gold Medal, Science History Institute and others  |  2019
  • honorary Doctorate, Utrecht University  |  2018
  • Catalyst Award, Science Club for Girls  |  2017
    Heinz Award, Heinz Family Foundation, in the Technology, the Economy and Employment category  | 2015
  • Lemelson-MIT Prize, Massachusetts Institute of Technology  |  2014
  • BEAM (Brown Engineering Alumni Medal) Award, Brown University School of Engineering  | 2011
  • Howard Hughes Medical Institute investigator  |  2008
  • Packard Fellowship, David and Lucile Packard Foundation  |  1999

Technologies

Methods and Uses for Remotely Triggered Protease Activity Measurements

Technology / Case number: #18272H
Sangeeta Bhatia / Simone Schuerle-Finke / Jaideep Dudani / Piyush Jain / Gabriel Kwong
Technology Areas: Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living
License

Highly Sensitive and Multiplexed Detection of Analytes with Mass Reporters and Quantitative Mass Spectrometry

Technology / Case number: #14585H
Sangeeta Bhatia / Gabriel Kwong
Technology Areas: Biotechnology / Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living
License

Tandem Peptide Approaches for Delivery to Gram-Negative Bacteria

Technology / Case number: #19017H
Sangeeta Bhatia / Leslie Chan / Ester Kwon
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

Nanosensors for Detecting and Imaging of Cancer Metastasis

Technology / Case number: #20490H
Sangeeta Bhatia / Liang Hao
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics
Impact Areas: Healthy Living
License

Multiplexed in Vivo Disease Sensing with Nucleic Acid-Barcoded Reporters enabling CRISPR-Cas-based Detection

Technology / Case number: #21723H
Sangeeta Bhatia / Chayanon Ngambenjawong / Renee Zhao / Liang Hao
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics
Impact Areas: Healthy Living
License

Activity-based Cell Sorting

Technology / Case number: #23765HJ
Sangeeta Bhatia / Ava Soleimany / Jesse Kirkpatrick
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
License

Activatable Antimicrobial Peptides and Uses Thereof

Technology / Case number: #24024H
Sangeeta Bhatia / Chayanon Ngambenjawong
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
License

Compositions for the Conditional Delivery of Macromolecules and Combination Therapeutics

Technology / Case number: #24492H
Sangeeta Bhatia / Qian Zhong / Edward Tan / Chayanon Ngambenjawong
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

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