Sangeeta Bhatia

John and Dorthy Wilson Professor

Department
Health Sciences and Technology Program
Technology Areas
Chemicals & Materials: Nanotechnology & Nanomaterials, Polymers, Composites, Catalysis & Synthesis / Drug Delivery: Microparticles & Nanoparticles / Therapeutics: Proteins & Antibodies, Small Molecules, Nucleic Acids, Cell Based Therapy, Regenerative Medicine / Biotechnology: Sensors & Monitoring, Cell Separation, Synthetic Biology, DNA & RNA Editing, Biomedical Devices & Systems / Diagnostics: Imaging Agents, Assays / Drug Discovery and Research Tools: Cell Interrogation / Sensing & Imaging: Chemical & Radiation Sensing, Optical Sensing / Biomaterials & Bioelectronics: Health Monitoring
Impact Areas

Integrating tissue engineering, nanotechnology, and microfabrication to create innovative liver models, diagnostic tools, and regenerative medicine strategies.

Background and Experience

The Bhatia Laboratory engineers micro and nanotechnologies, also called “tiny technologies,” to address complex challenges in human health ranging from cancer to liver disease and acquired infections. Operating at the interface of living and synthetic systems, the Bhatia group uses these miniaturization tools to improve areas of medicine including diagnostics, drug delivery, tissue regeneration, and disease modeling. In cancer, Bhatia’s multidisciplinary team develops tools for use in diagnostics and detection, and in precision therapeutics to specifically target tumors. Nanosensors designed by the Bhatia team are capable of detecting and profiling very early-stage tumors, and can be analyzed via a simple urine test. The same technology may also yield insights into a tumor’s response to certain therapies. The Bhatia Lab has also created human microlivers, which model human drug metabolism, liver disease, and interaction with pathogens.

Sangeeta Bhatia earned her BS at Brown University, followed by an MS in Mechanical Engineering at MIT, a PhD in Biomedical Engineering at the Harvard-MIT Division of Health Sciences and Technology, and an MD at Harvard Medical School. Prior to her appointment at MIT, Bhatia held a tenured position at UCSD. She and her trainees have launched multiple biotechnology companies to improve human health. 

Awards and Honors

  • Overseas Fellow of the Australian Academy of Technological Sciences and Engineering (FTSE)  | 2023
  • Othmer Gold Medal, Science History Institute and others  |  2019
  • honorary Doctorate, Utrecht University  |  2018
  • Catalyst Award, Science Club for Girls  |  2017
    Heinz Award, Heinz Family Foundation, in the Technology, the Economy and Employment category  | 2015
  • Lemelson-MIT Prize, Massachusetts Institute of Technology  |  2014
  • BEAM (Brown Engineering Alumni Medal) Award, Brown University School of Engineering  | 2011
  • Howard Hughes Medical Institute investigator  |  2008
  • Packard Fellowship, David and Lucile Packard Foundation  |  1999

Technologies

Method to Release Alcohol Reporters for Profiling Disease Characteristics in Breath

Technology / Case number: #25202H
Sangeeta Bhatia / Shih-Ting (Christine) Wang / Melodi Anahtar
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living
License

Activity-Based Nanosensors of Lung Cancer

Technology / Case number: #20311H
Sangeeta Bhatia / Jesse Kirkpatrick / Jaideep Dudani / Colin Buss / Andrew Warren
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living
License

Affinity-Based Detection of Ligand-Encoded Synthetic Biomarkers

Technology / Case number: #16292H
Sangeeta Bhatia / Andrew Warren / Kevin Lin / Gabriel Kwong / David Wood
Technology Areas: Biotechnology / Diagnostics
Impact Areas: Healthy Living
License

Engineered Probiotics for Urinary Cancer Diagnosis

Technology / Case number: #15881HJ
Sangeeta Bhatia / Jeff Hasty / Arthur Prindle / Tal Danino
Technology Areas: Biomaterials & Bioelectronics / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
License

Enhancing Video-Rate Fluorescence Imagery Collected in the Second Near-Infrared Optical Window for Diagnostic Real-Time Surgical and Post-Surgical Applications

Technology / Case number: #17022L
Sangeeta Bhatia / Adam Milstein / Alexander Bagley / Neelkanth Manoj Bardhan / Laura Brattain / Nandini Rajan / Lily Lee / Angela Belcher / Andy Siegel
Technology Areas: Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living
License

Programmable Drug Delivery Profiles of Tumor-Targeted Bacteria

Technology / Case number: #15818H
Sangeeta Bhatia / Tal Danino
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
License

Inhalable Nanosensors with Volatile Reporters for Rapid Pathogen Identification in Respiratory Infections

Technology / Case number: #20307HL
Rod Kunz / Melodi Anahtar / Leslie Chan / Sangeeta Bhatia
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics
Impact Areas: Healthy Living
License

Tissue Specific Delivery of Interfering RNA

Technology / Case number: #13947H
Sangeeta Bhatia / Yin Ren
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

Methods to Spatially Profile Protease Activity in Tissue and Sections

Technology / Case number: #19415H
Sangeeta Bhatia / Ester Kwon / Jaideep Dudani / Andrew Warren
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Diagnostics
Impact Areas: Healthy Living
License

Methods to Specifically Profile Protease Activity at Lymph Nodes

Technology / Case number: #18619H
Sangeeta Bhatia / Naveen Mehta / Jaideep Dudani / Andrew Warren / Karl Dane Wittrup / Darrell J Irvine
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Chemicals & Materials / Diagnostics
Impact Areas: Healthy Living
License

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