Sangeeta Bhatia

John and Dorthy Wilson Professor

Department
Health Sciences and Technology Program
Technology Areas
Chemicals & Materials: Nanotechnology & Nanomaterials, Polymers, Composites, Catalysis & Synthesis / Drug Delivery: Microparticles & Nanoparticles / Therapeutics: Proteins & Antibodies, Small Molecules, Nucleic Acids, Cell Based Therapy, Regenerative Medicine / Biotechnology: Sensors & Monitoring, Cell Separation, Synthetic Biology, DNA & RNA Editing, Biomedical Devices & Systems / Diagnostics: Imaging Agents, Assays / Drug Discovery and Research Tools: Cell Interrogation / Sensing & Imaging: Chemical & Radiation Sensing, Optical Sensing / Biomaterials & Bioelectronics: Health Monitoring
Impact Areas

Integrating tissue engineering, nanotechnology, and microfabrication to create innovative liver models, diagnostic tools, and regenerative medicine strategies.

Background and Experience

The Bhatia Laboratory engineers micro and nanotechnologies, also called “tiny technologies,” to address complex challenges in human health ranging from cancer to liver disease and acquired infections. Operating at the interface of living and synthetic systems, the Bhatia group uses these miniaturization tools to improve areas of medicine including diagnostics, drug delivery, tissue regeneration, and disease modeling. In cancer, Bhatia’s multidisciplinary team develops tools for use in diagnostics and detection, and in precision therapeutics to specifically target tumors. Nanosensors designed by the Bhatia team are capable of detecting and profiling very early-stage tumors, and can be analyzed via a simple urine test. The same technology may also yield insights into a tumor’s response to certain therapies. The Bhatia Lab has also created human microlivers, which model human drug metabolism, liver disease, and interaction with pathogens.

Sangeeta Bhatia earned her BS at Brown University, followed by an MS in Mechanical Engineering at MIT, a PhD in Biomedical Engineering at the Harvard-MIT Division of Health Sciences and Technology, and an MD at Harvard Medical School. Prior to her appointment at MIT, Bhatia held a tenured position at UCSD. She and her trainees have launched multiple biotechnology companies to improve human health. 

Awards and Honors

  • Overseas Fellow of the Australian Academy of Technological Sciences and Engineering (FTSE)  | 2023
  • Othmer Gold Medal, Science History Institute and others  |  2019
  • honorary Doctorate, Utrecht University  |  2018
  • Catalyst Award, Science Club for Girls  |  2017
    Heinz Award, Heinz Family Foundation, in the Technology, the Economy and Employment category  | 2015
  • Lemelson-MIT Prize, Massachusetts Institute of Technology  |  2014
  • BEAM (Brown Engineering Alumni Medal) Award, Brown University School of Engineering  | 2011
  • Howard Hughes Medical Institute investigator  |  2008
  • Packard Fellowship, David and Lucile Packard Foundation  |  1999

Technologies

Method to Release Alcohol Reporters for Profiling Disease Characteristics in Breath

Technology / Case number: #25202H
Melodi Anahtar / Shih-Ting (Christine) Wang / Sangeeta Bhatia
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living
License

Activity-Based Nanosensors of Lung Cancer

Technology / Case number: #20311H
Andrew Warren / Colin Buss / Jaideep Dudani / Jesse Kirkpatrick / Sangeeta Bhatia
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living
License

"Comet Chip": Electrophoresis of Arrayed Cells for Analysis of DNA Damage and Repair

Technology / Case number: #13158
Bevin Engelward / David Wood / David Weingeist / Sangeeta Bhatia
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
License

Affinity-Based Detection of Ligand-Encoded Synthetic Biomarkers

Technology / Case number: #16292H
David Wood / Gabriel Kwong / Kevin Lin / Andrew Warren / Sangeeta Bhatia
Technology Areas: Biotechnology / Diagnostics
Impact Areas: Healthy Living
License

Engineered Probiotics for Urinary Cancer Diagnosis

Technology / Case number: #15881HJ
Tal Danino / Arthur Prindle / Jeff Hasty / Sangeeta Bhatia
Technology Areas: Biomaterials & Bioelectronics / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
License

Enhancing Video-Rate Fluorescence Imagery Collected in the Second Near-Infrared Optical Window for Diagnostic Real-Time Surgical and Post-Surgical Applications

Technology / Case number: #17022L
Nandini Rajan / Laura Brattain / Neelkanth Manoj Bardhan / Alexander Bagley / Adam Milstein / Sangeeta Bhatia / Andy Siegel / Angela Belcher / Lily Lee
Technology Areas: Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living
License

Highly Parallel Profiling of Enzymes In Vivo Using Mass-Encoded Substrate Libraries

Technology / Case number: #13062
Geoffrey Von Maltzahn / Gabriel Kwong / Sangeeta Bhatia
Technology Areas: Biotechnology / Diagnostics / Therapeutics
Impact Areas: Healthy Living
License

Programmable Drug Delivery Profiles of Tumor-Targeted Bacteria

Technology / Case number: #15818H
Tal Danino / Sangeeta Bhatia
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
License

Inhalable Nanosensors with Volatile Reporters for Rapid Pathogen Identification in Respiratory Infections

Technology / Case number: #20307HL
Leslie Chan / Melodi Anahtar / Rod Kunz / Sangeeta Bhatia
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics
Impact Areas: Healthy Living
License

Tissue Specific Delivery of Interfering RNA

Technology / Case number: #13947H
Yin Ren / Sangeeta Bhatia
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

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