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Preferential Crystallization of fullrAAVs in a Hanging Drop Crystallizer as an Alternative Method for Downstream Purification of rAAV-based Gene Therapies

Technology / Case number: #24870
Anthony Sinskey / Vivekananda Bal / Moo Sun Hong / Stacy Springs / Richard D Braatz / Paul Barone
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Stable and Efficient Cell Surface Coupling of Nanoparticles

Technology / Case number: #17836HQ
Darrell J Irvine / Li Tang / Yiran Zheng
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Tandem Peptide Approaches for Delivery to Gram-Negative Bacteria

Technology / Case number: #19017H
Sangeeta Bhatia / Leslie Chan / Ester Kwon
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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System and Method for Automated Ovarian Follicular Monitoring

Technology / Case number: #19173PJ
Emery N Brown / Aaron Styer / Rose Faghih
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Communication Systems / Computer Science
Impact Areas: Healthy Living
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  • Women's Health
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1. Methods for in Vitro Evolution of Constructs Derived from Viruses. 2. Five Mutations Derived from the in Vitro Evolution. 3. Seventeen constructs from the five mutations.

Technology / Case number: #20395H
Darrell J Irvine / Yingzhong Li / Ron Weiss
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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MicroRNA-based Logic Gates that Do Not Use Exogenous Proteins

Technology / Case number: #21334
Ron Weiss / Giulio Alighieri
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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STING Agonist Delivery by Lipid Nanodiscs for Tumor Immunotherapy

Technology / Case number: #21441HJ
Darrell J Irvine / Masanori Okaniwa / Eric Dane
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Carbon Nanoparticles for use as a Vehicle to Target and Treat Macrophages, and Macrophage RNF41 as a Molecule Essential to Switch Macrophage Phenotype

Technology / Case number: #22023
Elazer R Edelman / Pedro Melgar Lesmes
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Control Replication and Transcription of Self-Replicating RNA in Responses to Small Molecule TMP

Technology / Case number: #22331H
Darrell J Irvine / Parisa Yousefpour / Jan Lonzaric / Yingzhong Li / Ron Weiss
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Catheter for Intracardiac 3D Bioprinting

Technology / Case number: #22338J
Brett E Bouma / Markus Horvath / Sophie Wang / Milen Shishkov / Victor Damptey / Connor Verheyen / Keegan Mendez / Ellen Roche / Sebastien Uzel / Jennifer Lewis
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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M13 Bacteriophage with a High Cysteine Content and Genetically Engineerable Hydrogels

Technology / Case number: #22369
Angela Belcher / Nimrod Heldman / William Records
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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Dynamic Control of a Fiber Manufacturing Process using Deep Reinforcement Learning

Technology / Case number: #22652
Brian Anthony / Sangwoon Kim / Donghyun Kim
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Communication Systems / Industrial Engineering & Automation
Impact Areas: Connected World
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Fusion Capsid Therapy for COVID-19 and Applies to Other Viruses: Universal "Dominant" Antiviral to Prevent Virus Evolution and Future Pandemics (DNA/RNA/Protein)

Technology, Tangible Property / Case number: #22801MH
Robert Langer / Bowen Li / Yong Qian / Alexi Choueiri / Edward Stuart Boyden / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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A Hybrid Polymeric System for Programmed Drug Release to the Heart

Exclusively Licensed Technology / Case number: #24959
Robert Langer / Erika Wang / Ana Jaklenec
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living

Interfacial Bioconjugation on Emulsion Droplets

Technology / Case number: #20314
Timothy Manning Swager / Qifan Zhang
Technology Areas: Chemicals & Materials / Drug Delivery / Sensing & Imaging
Impact Areas: Advanced Materials
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Chemiresistive Sensors Based on Carbon Nanotubes and Transition Metal Complexes

Technology / Case number: #20300
Timothy Manning Swager / Sibo Lin
Technology Areas: Chemicals & Materials / Communication Systems / Sensing & Imaging
Impact Areas: Connected World, Advanced Materials
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Shortwave Infrared Detection of Fluorescent Dyes

Technology / Case number: #18530
Moungi G Bawendi / Marianne Aellen / Daniel Franke / Jessica Carr / Tulio Valdez / Oliver Bruns
Technology Areas: Communication Systems / Sensing & Imaging
Impact Areas: Healthy Living
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Eliminating Channel Feedback in Next-Generation Cellular Networks

Technology / Case number: #18679
Dina Katabi / Deepak Vasisht / Swarun Suresh Kumar / Hariharan Rahul
Technology Areas: Communication Systems / Computer Science
Impact Areas: Connected World
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Planar Luneburg Lens System for Two-Dimensional Optical Beam Steering

Technology / Case number: #21298L
Steven G Johnson / Jamison Sloan / Samuel Kim / Josue Lopez / Dave Kharas / Suraj Bramhavar / Paul Juodawlkis / Cheryl Sorace-Agaskar / Jeffrey Herd / Marin Soljacic / George Barbastathis
Technology Areas: Chemicals & Materials / Communication Systems / Electronics & Photonics
Impact Areas: Connected World, Advanced Materials
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Forward Biased Modulator for Cryogenic Optical Link

Technology / Case number: #22040
Rajeev Ram / Marc de Cea Falco / Amir Atabaki / Dodd Gray
Technology Areas: Communication Systems / Electronics & Photonics
Impact Areas: Connected World, Advanced Materials
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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