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Designing Single Polymer Chain Nanoparticles to Mimic Biomolecular Hydration Frustration

Technology / Case number: #25875
Alfredo Alexander-Katz / Tianyi Jin / Connor Wilson Coley
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living
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Platform for Label-Free Recording/Imaging Metabolic Activity and Status in Cells

Technology / Case number: #25931P
W. David Lee / Rebecca Zubajlo / Tatsuya Osaki / Xiang (Shawn) Zhang
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Machine Learned Chemical Intuition for the AI Generation of Molecules within Specific Chemical Spaces

Technology / Case number: #26403
Brett McGuire / Zachary Fried
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Seqwell Ancillary Tools and Assays Including StimSeq and Spatial Barcoding

Technology / Case number: #19508
J. Christopher Love / Marc Wadsworth / Travis Hughes / Alex Shalek / Todd Gierahn
Technology Areas: Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Methods, Procedures, and Material Compositions to Formulate Thermally Stable Solid-State Lipid Nanoparticles via Drying at Ambient Conditions

Technology / Case number: #26177
Robert Langer / Amy Lee / Khanh Tran / Jinbi Tian / Mina Konakovic Lukovic / Ana Jaklenec
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Backbone Cleavable Polymethacrylates Via Optimized Thionolactone Comonoemers

Technology / Case number: #25292
Jeremiah A. Johnson / Kwangwook Ko
Technology Areas: Chemicals & Materials
Impact Areas: Sustainable Future, Advanced Materials
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Altered DNA Repair Pathway Engagement by Engineered CRISPR-Cas9 Nucleases

Technology / Case number: #23588
Robert Langer / Vikash Pal Singh Chauhan / Phillip Sharp
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Poly(-amino ester) Microparticles for Micronutrient Fortification

Technology / Case number: #22992
Robert Langer / Linzixuan Rhoda Zhang / Ruiqing Xiao / Ana Jaklenec
Technology Areas: Agriculture & Food / Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living
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Automated Flow Synthesis of Combinatorial Protein Libraries

Technology / Case number: #26382J
Bradley L. Pentelute / Dimuthu Vithanage / Corey Johnson / John Albin / Gha Young Lee / Wayne Vuong
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Silicone Valve API Compartment Sealing Barrier

Technology / Case number: #21569QJ
Giovanni Traverso / Brian Jensen / Mikkel Oliver Jespersen / Morten Frederiksen / Alex Abramson
Technology Areas: Biomaterials & Bioelectronics / Chemicals & Materials / Industrial Engineering & Automation
Impact Areas: Healthy Living
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Polymer Film for BNL

Technology / Case number: #26245
Brian L Wardle / Robert Sansone / Yuying Lin / Carina Xiaochen Li
Technology Areas: Chemicals & Materials
Impact Areas: Advanced Materials
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Plk1 inhibitor and Microtubule Poison Dual Payload Antibody Drug Conjugates for the Treatment of Cancer

Technology / Case number: #26136
Michael Yaffe / Jesse C Patterson
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Utilizing a Strategic Blend of Block Copolymers to Control Particle Surface Charge for Enhanced Mucus Transport and Tissue Targeting

Technology / Case number: #25439J
Angela Belcher / Brian Wilson / Boris Sevarika / Robert Prud'homme / Corey Alfred Stevens / Katharina Ribbeck
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living
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Methods for Microbial Oil Overproduction from Cellulosic Materials

Technology / Case number: #15695
Gregory Stephanopoulos / Mitchell Tai
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Environmental Engineering
Impact Areas: Healthy Living, Sustainable Future
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Liquid Crystal Alignment Layer

Technology / Case number: #17358LJ
Carl Bozler / Douglas Bryant / Philip Bos / Valerie Finnemeyer / Shaun Berry / Robert Reich / Harry Clark
Technology Areas: Chemicals & Materials / Electronics & Photonics
Impact Areas: Connected World
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Colloidal Hydrogel Particles with tunable Chemistry, Geometry, and Flexibility

Technology / Case number: #13461J
Mehmet Toner / Patrick Doyle
Technology Areas: Chemicals & Materials / Computer Science
Impact Areas: Healthy Living
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Reprogram the Genome of M13 Phage for Vaccination and Immunotherapy Applications

Technology / Case number: #25169
Angela Belcher / Shengnan Huang
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Methods for Improving Statistical Power in Genetic Discovery by Incorporating Quality Control Flags

Technology / Case number: #25839P
Manolis Kellis / Yosuke Tanigawa
Technology Areas: Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Expression Constructs for One-Step Construction of Allogeneic CAR-NK Cells

Technology, Tangible Property / Case number: #26118J
Jianzhu Chen / Fuguo Liu / Rizwan Romee
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Connected World
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Using a Genetically Modified Human IPS Line to Screen for Drugs that Prevent or Treat Alzheimer's Disease

Technology / Case number: #26292P
Li-Huei Tsai / Masayuki Nakano / Matheus Victor / Leyla Akay / TaeHyun Kim
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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