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Discovery and Engineering of Novel Integrases for High-Efficiency Gene Integration

Technology / Case number: #23554
Omar Abudayyeh / Justin Lim / Lukas Villiger / Jonathan S. Gootenberg
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Flow Cytometry with Mass Sensitive Readout

Technology / Case number: #12273J
Scott Manalis / Ken Babcock / Michel Godin / Thomas Burg
Technology Areas: Biotechnology / Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living
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Biodegradable Lipid-Like Materials for Applications in siRNA Delivery

Technology / Case number: #15420
Robert Langer / Joseph Dorkin / Yunlong Zhang / Arturo Vegas / Kathryn Whitehead / Daniel Anderson
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Raman Spectroscopy Based Sensitive and Specific Detection of Alternate Glycemic Markers, Glycated Hemoglobin (HbA1c) and Glycated Albumin for Longterm Diabetes Monitoring

Technology / Case number: #15295
Ramachandra Dasari / Jeon Woong Kang / Narahara Dingari / Ishan Barman
Technology Areas: Biotechnology / Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living
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2-Aminoindole-Class Antimalarials

Technology / Case number: #14097BJ
Jon Clardy / Elyse Bourque / Yibin Xiang / Renato Skerlj / Edmund Sybertz / Joseph Cortese / Mary Lynn Baniecki / Roger Wiegand / Dyann Wirth / Cassandra Celatka / Sameer Urgaonkar / Ralph Mazitschek
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Imidazole-Based Random Co-Polymer for Synthesis of Water Soluble Biocompatible Semiconductor Nanocrystals

Technology / Case number: #13877
Moungi G Bawendi / Peter Allen / Wenhao Liu / Numpon Insin
Technology Areas: Chemicals & Materials / Diagnostics / Electronics & Photonics
Impact Areas: Healthy Living
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Programmable Insertion Approaches Via Reverse Transcriptase Recruitment

Technology / Case number: #23685
Omar Abudayyeh / Kaiyi Jiang / Lukas Villiger / Jonathan S. Gootenberg
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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1,3,5-triazinane-2,4,6-trione (TNT) Derivatives and Uses Thereof

Technology / Case number: #15446
Robert Langer / Hao Yin / Akinleye Alabi / Joseph Dorkin / Ahmed Eltoukhy / Yizhou Dong / Delai Chen / Daniel Anderson
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Heterocycle-Modified Quinolines for Fluorescence-Based Protein Kinase Sensing

Technology / Case number: #13876
Barbara Imperiali / Juan Gonzalez Vera / Elvedin Lukovic
Technology Areas: Biotechnology / Diagnostics / Therapeutics
Impact Areas: Healthy Living
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sMutants of Channelrhodopsins with Altered Ion Selectivity

Technology / Case number: #16934TE
Edward Stuart Boyden / Fei Chen / Yongku Cho / Amy Chuong / Nathan Klapoetke
Technology Areas: Electronics & Photonics / Therapeutics
Impact Areas: Healthy Living
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A Novel Multiplexed Inertial Focusing Microfiltration System for Intra-Operative Blood Salvage Autotransfusion

Technology / Case number: #17212DJE
Jongyoon Han / Kah Ping Andy Tay / Majid Ebrahimi Warkiani / Lidan Wu / Guofeng Guan / Chwee-Teck Lim
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Olfactory Receptor-Based Devices

Technology / Case number: #12776TE
Shuguang Zhang / Liselotte Kaiser / Joanke (Johanna) Bikker Graveland / Brian Cook / Andreas Mershin / Manu Prakash / David Kong / Yael Maguire
Technology Areas: Biotechnology / Chemicals & Materials / Computer Science / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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SNAPPLE - Sequencing-Mediated Numerical Analysis of Parallel Proximity Ligation Events

Technology / Case number: #13615B
Andreas Gnirke / Daniel Aird / Erez Lieberman
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Colon Delivery Platform for Constipation Treatment

Technology / Case number: #20570JQ
Robert Langer / Christoph Winfried Johannes Steiger / Joshua Korzenik / Giovanni Traverso
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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A Novel Injectable Thiol-Acrylate Poly(ethylene Glycol) Hydrogel for Sustained Release of Methylprednisolone Sodium Succinate

Technology / Case number: #14439J
Robert Langer / Jonathan Slotkin / Francis Reynolds / Timothy O'Shea / Daniel Siegwart / Christopher Pritchard / Eric Woodard / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Translocation of Non-Natural Chemical Entities Through Anthrax Protective Antigen Pore

Technology / Case number: #15639J
Bradley L. Pentelute / R. Collier / Gizem Akcay / Jingjing Ling / Amy Rabideau / Xiaoli Liao
Technology Areas: Computer Science / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Self Assembled RSV Nanoparticle Vaccines

Technology / Case number: #16549
Ram Sasisekharan / Aditya Raguram / Vidya Subramanian
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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CD80 is a Biomarker of p53 Activity and a Target for Cancer Therapy

Technology / Case number: #15386H
Tyler Jacks / Leah Schmidt / David Feldser
Technology Areas: Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Valency Controlled Quantum Dots with Tunable Number of Biotin Binding Sites

Technology / Case number: #12606B
Moungi G Bawendi / Wenhao Liu / Mark Howarth / Alice Ting
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics / Electronics & Photonics / Therapeutics
Impact Areas: Healthy Living
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Methods and Compositions for Protein Labeling Using Lipoic Acid Ligases

Technology / Case number: #12773
Alice Ting / Marta Fernandez Suarez / Yoon-Aa Choi / Hemanta Baruah
Technology Areas: Biotechnology / Diagnostics / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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