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Tissue-integrating Neural Interfaces

Technology / Case number: #24351
Polina Anikeeva / Anthony Tabet
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Chemicals & Materials / Sensing & Imaging
Impact Areas: Healthy Living, Advanced Materials
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Compositions for the Conditional Delivery of Macromolecules and Combination Therapeutics

Technology / Case number: #24492H
Chayanon Ngambenjawong / Edward Tan / Qian Zhong / Sangeeta Bhatia
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Autocatalytic Base Editing for RNA-Responsive Translational Control

Technology / Case number: #24552YJ
James Collins / Raphael Gayet / Katherine Ilia / Shiva Razavi / Nathaniel Tippens / Kehan Zhang / Xiaoyu Chen / Jonathan Chen / Makoto Lalwani
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Controlled Lipid Self-Assembly for Scalable Manufacturing of Next-Generation Immune Stimulating Complexes

Technology / Case number: #24582H
Ivan Susin Pires / Darrell Irvine / Paula Hammond
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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High Throughput Stochastic Bio-Molecular Sensor

Technology / Case number: #24610
Ashwin Gopinath / Swathi Manda
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Diagnostics
Impact Areas: Healthy Living
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Drinkable, Tough Hydrogels for Gastrointestinal Applications

Technology / Case number: #24642J
Carlo Giovanni Traverso / Robert Langer / Gary Liu / Matthew Pickett
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Non-Fibrotic Implantable Devices on Diverse Organs

Technology / Case number: #24648
Xuanhe Zhao / Hyunwoo Yuk / Jingjing Wu / Jue Deng
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living, Advanced Materials
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System and Methods for Noninvasive Point-of-Care Intracranial Pressure, Intracranial Compliance, and Cerebrovascular Resistance Measurement

Technology / Case number: #24678
Thomas Heldt / Syed Imaduddin / Charles Sodini
Technology Areas: Biomaterials & Bioelectronics / Biotechnology
Impact Areas: Healthy Living
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Targeted Layered Lipid Nanoparticles for in Vivo Extrahepatic Gene Delivery

Technology / Case number: #24751
Namita Nabar / Tamara Dacoba / Paula Hammond
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Modulating Oncogenic Transcriptional Dysregulation with Small Molecule Chimeric Degraders of Cyclin-Dependent Kinase 9

Technology / Case number: #24831
Angela Koehler / Mohammed Toure / Keisuke Motoyama
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Implantable device to ensure stoma patency following Endoscopic Third Ventriculostomy Procedure

Technology / Case number: #24977
Ellen Roche / Luca Rosalia / Bryce Starr / Gabriel Friedman / Jonas Sogbadji
Technology Areas: Biotechnology
Impact Areas: Healthy Living
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Recombinant Transmembrane Domain-Deficient STING as Biomimetic Protein Carrier for cGAMP Enhanced Cancer Immunotherapy

Technology / Case number: #25012
Jiahe Li / Yanpu He / Shengnan Huang / Celestine Jia Huey Hong / Paula Hammond / Angela Belcher
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Tool for Spatially Targeted Access and Placement of Hardware or Drugs in Deep or Consolidated Tissues

Technology / Case number: #25071
Shriya Srinivasan / Robert Langer / Alexander Madinger
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living
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Mechanisms for Controlled Volume Injection into a Soft Media with Concurrent Pressure Measurement

Technology / Case number: #25109
Nevan Hanumara / Tal Cohen / Alexander Slocum / Brendan Unikewicz / Emily Sologuren / Joseph Morales / Andre Pincot / Sarah Sams
Technology Areas: Biotechnology
Impact Areas: Healthy Living
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Augmentation of T and B Cell Activation with a Novel Cysteine Protease Linker Sequence

Technology / Case number: #25338
Sean-Luc Shanahan / Tyler Jacks
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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An Efficient Bioconjugation Technology for Site-Selective Covalent Modification of Antibodies using an Engineered Affinity Peptide

Technology / Case number: #25358
Bradley Pentelute / Andrei Ioan Loas / Jacob Rodriguez / Heemal Dhanjee / Aurelie Rondon / Katsushi Kitahara
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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A Machine Learning-guided Whole-Organ Optical Imaging Technique for Non-destructive Identification of Early Pre-Cancer Lesions and Harvesting of Viable Cells from the same for Organoid Culture

Technology / Case number: #25480
Neelkanth Bardhan / Vivek Rastogi / Angela Belcher
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Electronics & Photonics / Sensing & Imaging
Impact Areas: Healthy Living
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Tuning Chloroplast Transgene Expression from Synthetic Operon

Technology / Case number: #25494
Christopher Voigt / Qiguo Yu
Technology Areas: Agriculture & Food / Biotechnology / Therapeutics
Impact Areas: Healthy Living
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System and Method for Automated Ovarian Follicular Monitoring

Technology / Case number: #19173PJ
Emery Brown / Rose Faghih / Aaron Styer
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Communication Systems / Computer Science
Impact Areas: Healthy Living
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Tandem Peptide Approaches for Delivery to Gram-Negative Bacteria

Technology / Case number: #19017H
Ester Kwon / Leslie Chan / Sangeeta Bhatia
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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