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Autocatalytic Base Editing for RNA-Responsive Translational Control

Technology / Case number: #24552YJ
James Collins / Raphael Gayet / Katherine Ilia / Shiva Razavi / Nathaniel Tippens / Kehan Zhang / Xiaoyu Chen / Jonathan Chen / Makoto Lalwani
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Controlled Lipid Self-Assembly for Scalable Manufacturing of Next-Generation Immune Stimulating Complexes

Technology / Case number: #24582H
Ivan Susin Pires / Darrell Irvine / Paula Hammond
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Drinkable, Tough Hydrogels for Gastrointestinal Applications

Technology / Case number: #24642J
Carlo Giovanni Traverso / Robert Langer / Gary Liu / Matthew Pickett
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Targeted Layered Lipid Nanoparticles for in Vivo Extrahepatic Gene Delivery

Technology / Case number: #24751
Namita Nabar / Tamara Dacoba / Paula Hammond
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Modulating Oncogenic Transcriptional Dysregulation with Small Molecule Chimeric Degraders of Cyclin-Dependent Kinase 9

Technology / Case number: #24831
Angela Koehler / Mohammed Toure / Keisuke Motoyama
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Recombinant Transmembrane Domain-Deficient STING as Biomimetic Protein Carrier for cGAMP Enhanced Cancer Immunotherapy

Technology / Case number: #25012
Jiahe Li / Yanpu He / Shengnan Huang / Celestine Jia Huey Hong / Paula Hammond / Angela Belcher
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Augmentation of T and B Cell Activation with a Novel Cysteine Protease Linker Sequence

Technology / Case number: #25338
Sean-Luc Shanahan / Tyler Jacks
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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An Efficient Bioconjugation Technology for Site-Selective Covalent Modification of Antibodies using an Engineered Affinity Peptide

Technology / Case number: #25358
Bradley Pentelute / Andrei Ioan Loas / Jacob Rodriguez / Heemal Dhanjee / Aurelie Rondon / Katsushi Kitahara
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Tuning Chloroplast Transgene Expression from Synthetic Operon

Technology / Case number: #25494
Christopher Voigt / Qiguo Yu
Technology Areas: Agriculture & Food / Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Tandem Peptide Approaches for Delivery to Gram-Negative Bacteria

Technology / Case number: #19017H
Ester Kwon / Leslie Chan / Sangeeta Bhatia
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Locally Delivered Therapeutics and Combinations for Expedited Passage of Urinary Stones

Technology / Case number: #19454J
Michael Cima / Xiang Li / Brian Eisner
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Mammalian Synthetic Biology Approaches for the Precise Control of mAb N-Glycosylation (Pfizer-MIT PTM Track 2 Interim Joint Summary Document)

Technology / Case number: #19972J
Timothy Lu / Ron Weiss / Nevin Summers / Wen Tseng / Leonid Gaydukov / Michelle Chang / Giyoung Jung / Richard Cornell / Jeffrey Marshall / John Scarcelli / Bruno Figueroa
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Catheter for Intracardiac 3D Bioprinting

Technology / Case number: #22338J
Jennifer Lewis / Sebastien Uzel / Ellen Roche / Keegan Mendez / Connor Verheyen / Victor Damptey / Milen Shishkov / Sophie Wang / Markus Horvath / Brett Bouma
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Control Replication and Transcription of Self-Replicating RNA in Responses to Small Molecule TMP

Technology / Case number: #22331H
Ron Weiss / Yingzhong Li / Jan Lonzaric / Parisa Yousefpour / Darrell Irvine
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Intra-Tumoral Injection of Cytotoxic Chemotherapy-Treated Tumor Cells in Combination with Systemic Immune Checkpoint Blockade for Cancer Treatment

Technology / Case number: #21498H
Ganapathy Sriram / Lauren Milling / Darrell Irvine / Michael Yaffe
Technology Areas: Diagnostics / Therapeutics
Impact Areas: Healthy Living
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STING Agonist Delivery by Lipid Nanodiscs for Tumor Immunotherapy

Technology / Case number: #21441HJ
Eric Dane / Masanori Okaniwa / Darrell Irvine
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Uses of Amphiphiles in Immune Cell Therapy and Compositions Therefore

Technology / Case number: #21411H
Peter DeMuth / Darrell Irvine
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Circular, Strained Zymogen

Technology / Case number: #21110J
Ronald Raines / Ian Windsor
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Use of Choline Supplementation as Therapy for APOE4-Related Disorders

Technology / Case number: #20957WPJ
Li-Huei Tsai / Yuan-Ta Lin / Julia Bonner / Priyanka Narayan / Greg Sienski
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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1. Methods for in Vitro Evolution of Constructs Derived from Viruses. 2. Five Mutations Derived from the in Vitro Evolution. 3. Seventeen constructs from the five mutations.

Technology / Case number: #20395H
Ron Weiss / Yingzhong Li / Darrell Irvine
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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