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Structure-Guided Chemical Modification of Guide RNA and its Applications

Technology / Case number: #19175V
Robert Langer / Hao Yin / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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sgRNA Chemical Modification for Efficient Gene Editing

Technology / Case number: #17805V
Robert Langer / Hao Yin / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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A Generalizable, High-Throughput Method to Rapidly add Chemical Moieties to a Small Molecule Library

Technology / Case number: #22196J
Angela Koehler / Chia-fu Chang / Christina Woo / Sebastian Pomplun / Catherine Henry / Jasmin Kruell / Brice Curtin
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Synthesis of Ester, Carbonate, and Carbamate-derived Novel Biodegradable Ionizable Lipids from Methyl Ricinoleate or Methyl 12-Hydroxystearate and its Applications

Technology / Case number: #23381Q
Daniel Anderson / Jacob Witten / rajith manan / Akiva Gordon / Bowen Li / Luke Rhym
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Optimized Alum-Anchored HIV Env Immunogens

Technology / Case number: #24972HJ
Darrell J Irvine / William Schief / Jon Steichen / Christopher Cottrell / Kristen Rodrigues
Technology Areas: Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Biodegradable Lipids and Formulations for Intramuscular, In Vitro, and Ex Vivo Transfection of mRNA

Technology / Case number: #23969J
Daniel Anderson / Kaelan Reed / Akash Gupta / Arnab Rudra
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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A Diagnostic and Treatment Prediction Toolkit for Bipolar Disorder based on Polymorphisms in CPG2 Regulatory Domains

Technology / Case number: #23591P
Elly Nedivi / Baovi Vo
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Dielectric Films for the Control of Cell Adhesion

Technology / Case number: #23881
Kripa K Varanasi / Sophia Sonnert / Baptiste Blanc / Victor Leon
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Advanced Materials
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Fluorescence-based detection of protein aggregation and fiber optic-based benchtop instrument

Technology / Case number: #21556
Michael S. Strano / Freddy Nguyen / Sooyeon Cho / Daniel Salem / Xun Gong / Daichi Kozawa
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Multi-Input miRNA Sensing with Constitutive ERNs to Regulate Multi-Output Gene Expression in Mammalian Cells

Technology / Case number: #23123
Ron Weiss / Lei Wang / Wenlong Xu / Erez Pery / Deepak Mishra
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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A Fabrication-Free Microfluidic Device for Scalable, High-Volume Bacterial Electroporation

Technology / Case number: #23552
Cullen R. Buie / Sijie Chen / Po-Hsun Huang
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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High-Throughput and High-Precision Measurement of Single-Cell Density

Technology / Case number: #23740
Scott Manalis / Teemu Miettinen / Weida Wu
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Intracellular Molecular Recording and Memory via Protein Self-Assembly

Technology / Case number: #23746HPM
Edward Stuart Boyden / Changyang Linghu
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Activity-based Cell Sorting

Technology / Case number: #23765HJ
Sangeeta Bhatia / Ava Soleimany / Jesse Kirkpatrick
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Smooth Flow Control Systems for Embedded Micropumps on Microfluidic Cell Culture Devices

Technology / Case number: #24379
Linda Griffith / Allison Lenhard / David L Trumper
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Autocatalytic Base Editing for RNA-Responsive Translational Control

Technology / Case number: #24552YJ
James Collins / Makoto Lalwani / Jonathan C. Chen / Xiaoyu Chen / Kehan Zhang / Nathaniel Tippens / Shiva Razavi / Katherine Ilia / Raphael Gayet
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Temporally Multiplexed Imaging Technology

Technology / Case number: #24554MH
Edward Stuart Boyden / Yong Qian
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Library-Scale Methods for Antibody Functional Screening

Technology / Case number: #24645
Brandon DeKosky
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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In Solution Monoclonal Polony Generation on Inorganic Nanoparticle

Technology / Case number: #25039
Ashwin Gopinath / Emily Wu / Nayan Agarwal
Technology Areas: Chemicals & Materials / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Advanced Materials
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Lung-Cancer Specific T Cell Dysfunction

Technology / Case number: #23004
Karl Dane Wittrup / Duncan Morgan / Brendan Horton / Stefani Spranger / J. Christopher Love
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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