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Recombinase-Based Genetic Diversification Schemes

Technology / Case number: #18173
Timothy Lu / Sara Da Luz Areosa Cleto
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Multilayer Genetic Safety Kill Circuits Based on Single Cas9 Protein and Multiple Engineered gRNA in Mammalian Cells

Technology / Case number: #18163
Ron Weiss / Mohammad Reza Ebrahimkhani / Samira Kiani
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
License

Method to Treat Amblyopia

Technology / Case number: #18125PH
Mark Bear / Jeffrey Gavornik / Kevin Duffy / Donald Mitchell / Ming-fai Fong / Arnold Heynen
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
License

Method to Distinguish and Analyze White Blood Cells in the Presence of Red Blood Cells

Technology / Case number: #18889
Shivang Dave / Jason Tucker-Schwartz
Technology Areas: Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Electromechanical Lysis of Bacterial Pathogens using Ion Concentration Polarization

Technology / Case number: #19035
Minseok Kim / Jongyoon Han
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
License

Atherofluidics-on-Chip

Technology / Case number: #18096
Sarvesh Varma / Joel Voldman
Technology Areas: Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Compositions and Methods for Treating and Preventing Obesity

Technology / Case number: #18085J
Manolis Kellis / Melina Claussnitzer / Jan Korbel
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
License

Open-Ended, Dicer-Cleavable Concatemeric siRNA Generated by Rolling Circle Transcription

Technology / Case number: #18076
Connie Wu / Kevin Shopsowitz / Paula Hammond
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
License

Development of Multi-Specific Antibody-Serum Albumin Fusion Proteins Targeting Multiple Human and Murine CXC (ELR+) Chemokines

Technology / Case number: #19355JQ
Alessandro Angelini / Andrew Luster / Karl Wittrup
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
License

Delivery of Preassembled Double-Stranded Short Interference RNA-Argonaute Protein Complexes for Enhanced RNAi-Based Therapeutics

Technology / Case number: #19340
Jiahe Li / Yanpu He / Wade Wang / Paula Hammond
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Uncharted Frontiers
License

Discovery of Self-Labeling Miniproteins

Technology / Case number: #18742
Bradley Pentelute / Ethan Evans
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Uncharted Frontiers, Advanced Materials
License

METRAN - Software for 13C-metabolic Flux Analysis

Software / Case number: #12397
Technology Areas: Biotechnology / Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Connected World
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Structured DNA Conjugates

Technology / Case number: #18588
Mark Bathe / Sakul Ratanalert / Remi Veneziano / Tyson Shepherd / Hyungmin Jun
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
License

N/ASynergistic Tumor Treatment with IL-2, an Integrin-Binding-FC Fusion Protein, and a Cancer Vaccine

Technology / Case number: #18598HJ
Byron Kwan / Cary Opel / Kelly Moynihan / Darrell Irvine / Jennifer Cochran / Karl Wittrup
Technology Areas: Drug Discovery and Research Tools / Therapeutics
License

Highly Parallel Enzymatic DNA Synthesis Using Electrowetting Droplet Technology

Technology / Case number: #19620
Mark Bathe / Tyson Shepherd / James Banal / Joseph Berleant
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
License

Methods for Gene Delivery with Papillomaviruses

Technology / Case number: #21704
Omar Abudayyeh / Jonathan Gootenberg
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
License

Removal of Ruthenium-Initiator from Brush-Arm Star Polymers (BASPs) via Core-to-Surface Ring-Opening Methathesis Polymerization (ROMP)

Technology / Case number: #19525
Jeremiah Johnson / Matthew Golder
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
License

Magnetic Nanodiscs Mediate Remote Magnetomechanical Control of Neural Calcium

Technology / Case number: #20085
Polina Anikeeva / Alexander Senko / Danijela Gregurec / Pooja Reddy
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Advanced Materials
License

RNA-Based Regulatory Technologies for Improved miRNA Sensors

Technology / Case number: #19686
Ron Weiss / Kevin Lebo / Jin Huh
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
License

Novel Peptidic Agents for Targeting Chemoresistant Anti-Apoptotic Bfl-1

Technology / Case number: #18607
Amy Keating / Justin Jenson
Technology Areas: Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
License

The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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