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Compositions for the Conditional Delivery of Macromolecules and Combination Therapeutics

Technology / Case number: #24492H
Chayanon Ngambenjawong / Edward Tan / Qian Zhong / Sangeeta Bhatia
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Targeted Layered Lipid Nanoparticles for in Vivo Extrahepatic Gene Delivery

Technology / Case number: #24751
Namita Nabar / Tamara Dacoba / Paula Hammond
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Tandem Peptide Approaches for Delivery to Gram-Negative Bacteria

Technology / Case number: #19017H
Ester Kwon / Leslie Chan / Sangeeta Bhatia
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Control Replication and Transcription of Self-Replicating RNA in Responses to Small Molecule TMP

Technology / Case number: #22331H
Ron Weiss / Yingzhong Li / Jan Lonzaric / Parisa Yousefpour / Darrell J Irvine
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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STING Agonist Delivery by Lipid Nanodiscs for Tumor Immunotherapy

Technology / Case number: #21441HJ
Eric Dane / Masanori Okaniwa / Darrell J Irvine
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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1. Methods for in Vitro Evolution of Constructs Derived from Viruses. 2. Five Mutations Derived from the in Vitro Evolution. 3. Seventeen constructs from the five mutations.

Technology / Case number: #20395H
Ron Weiss / Yingzhong Li / Darrell J Irvine
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Preferential Crystallization of fullrAAVs in a Hanging Drop Crystallizer as an Alternative Method for Downstream Purification of rAAV-based Gene Therapies

Technology / Case number: #24870
Paul Barone / Richard D Braatz / Anthony Sinskey / Stacy Springs / Moo Sun Hong / Vivekananda Bal
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Medical Recordkeeping Microneedles

Technology / Case number: #24923
Ana Jaklenec / Robert Langer / Maria Kanelli / Jooli Han / Yang Liu / Fredo Durand (he/him/his)
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Carbon Nanoparticles for use as a Vehicle to Target and Treat Macrophages, and Macrophage RNF41 as a Molecule Essential to Switch Macrophage Phenotype

Technology / Case number: #22023
Elazer R Edelman / Pedro Melgar Lesmes
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Catheter for Intracardiac 3D Bioprinting

Technology / Case number: #22338J
Jennifer Lewis / Sebastien Uzel / Ellen Roche / Keegan Mendez / Connor Verheyen / Victor Damptey / Milen Shishkov / Sophie Wang / Markus Horvath / Brett E Bouma
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Fusion Capsid Therapy for COVID-19 and Applies to Other Viruses: Universal "Dominant" Antiviral to Prevent Virus Evolution and Future Pandemics (DNA/RNA/Protein)

Technology, Tangible Property / Case number: #22801MH
Edward Stuart Boyden / Robert Langer / Alexi Choueiri / Yong Qian / Bowen Li / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Organogels for Epidermal Drug Delivery

Technology / Case number: #23303J
Xuanhe Zhao / Xinyue Liu / Xiaoyu Chen / Weibo Wang
Technology Areas: Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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Nucleic Acid-Conjugated Polymeric Nanoparticles for Gene Therapy

Technology / Case number: #23628JQ
Natalie Artzi / Pere Dosta Pons / Alexander M Cryer
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Adhesive, Injectable Hydrogels for Local Therapy Delivery to Brain Tumors

Technology / Case number: #24170JQ
Natalie Artzi / Michelle Dion / Dahis Daniel
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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A High-Energy Rechargeable Al-CO2 Battery for CO2 Capture/Conversion and Electric Power Generation/Storage

Technology / Case number: #21609
Shuya Wei / Angela Belcher / Jifa Qi
Technology Areas: Energy & Distribution / Environmental Engineering
Impact Areas: Climate Stabilization
Labels
  • CO2 Capture
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Stable and Efficient Cell Surface Coupling of Nanoparticles

Technology / Case number: #17836HQ
Yiran Zheng / Li Tang / Darrell J Irvine
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Lipid Nanoparticles for Drug Delivery to Microglia in the Brain

Technology / Case number: #23156P
Li-Huei Tsai / Owen Fenton / Joel Blanchard / Robert Langer / Jason Andresen / Julia Bonner / William Ralvenius
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Redox-Electrodes for Electrochemically-Controlled Bio-Macromolecule Interaction: Bio-Separations, Heterogeneous Enzyme Immobilization, Protein Purification and Sensing, Among Others

Technology / Case number: #18540
T. Alan Hatton / Xiao Su
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Environmental Engineering
Impact Areas: Sustainable Future, Advanced Materials
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Task Specific Ionic Liquids for Electrochemically Mediated Scrubbing of CO2

Technology / Case number: #18537
T. Alan Hatton / Paul Brown / Sahag Voskian
Technology Areas: Environmental Engineering
Impact Areas: Climate Stabilization, Sustainable Future
Labels
  • CO2 Capture
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Polymer Based Solid-State Solar Thermal Fuels

Technology / Case number: #18399
Jeffrey C. Grossman / David Zhitomirsky
Technology Areas: Chemicals & Materials / Energy & Distribution / Environmental Engineering
Impact Areas: Sustainable Future, Advanced Materials
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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