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Ionizable Lipids for Messenger RNA Delivery

Technology, Tangible Property / Case number: #24861
Jacob Witten / Idris Raji / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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A Generalizable, High-Throughput Method to Rapidly add Chemical Moieties to a Small Molecule Library

Technology / Case number: #22196J
Angela Koehler / Brice Curtin / Jasmin Kruell / Catherine Henry / Sebastian Pomplun / Christina Woo / Chia-fu Chang
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Small Molecule Inhibitors of Interleukin-4

Technology / Case number: #22186
Angela Koehler / Arturo Vegas / Shelby Doyle / Becky Leifer / Sean Quinnell / Stephen Nestor / Kelly Tan / Luke Ceo / Daniel Sheehy
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Chimeric Degraders of Cyclin Dependent Kinase 9 with Potential Use for Cancer Therapy

Technology / Case number: #22028
Angela Koehler / Andre Richters / Julie Urgiles / Florian Kabinger / Mohammed Toure
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Small Molecule Modulators of the Androgen Receptor

Technology / Case number: #19771
Angela Koehler / Nicholas Struntz / David Freeman / Shelby Doyle / Andre Richters
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Novel Max Binders Modulators of Myc-Mediated Transcription with Potential Use for Cancer Therapy

Technology / Case number: #18257
Angela Koehler / Eric Stefan / Francisco Caballero Gonzalez / Dylan Neel / Helen Evans / Nicholas Struntz / Andrew Chen
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Hybrid Materials with Living Cells and Tough Hydrogels

Technology / Case number: #18548
Timothy Lu / Xuanhe Zhao / Eleonore Tham / Xinyue Liu / Tzu-Chieh Tang
Technology Areas: Biomaterials & Bioelectronics / Chemicals & Materials / Diagnostics / Therapeutics
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Pooled Screening Identifies Genomic Features (Biomarkers) Modulating Nanoparticle-Cell Interactions

Technology / Case number: #22785J
Angela Koehler / Natalie Boehnke / Joelle Straehla / Paula Hammond
Technology Areas: Diagnostics / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Cationic Lipidoids and Their Uses for Immunotherapy

Technology / Case number: #19803
Linxian Li / Yuxuan Huang / Lei Miao / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Spatially Localized Gene Delivery of Adeno-Associated Viruses

Technology / Case number: #25055
Polina Anikeeva / Keisuke Nagao
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Lipid Anchorage of Cytokines onto Layer-by-Layer Nanoparticles

Technology / Case number: #25070H
Ivan Susin Pires / Darrell Irvine / Paula Hammond
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Ultrastructural Membrane Expansion Microscopy

Technology / Case number: #25088HM
Edward Boyden / Tay Won Shin
Technology Areas: Chemicals & Materials / Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living
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Cell-Surface Anchored Cytokine Therapy

Technology, Tangible Property / Case number: #25245H
Luciano Santollani / Darrell Irvine / Karl Wittrup
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Engineered Synthetic IRES with Improved and Robust Translation in Circular RNA

Technology / Case number: #25300YJ
James Collins / Katherine Ilia / Shiva Razavi / Kehan Zhang / Xiaoyu Chen / Makoto Lalwani / Yu Li / Nayoung Kim
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Combinations of Anesthetics as Therapies for Treatment-Resistant Depression

Technology / Case number: #25342P
Emery Brown / Sirma Orguc / Ohyoon Kwon / Bryan Tseng / Macauley Breault / Gloria Kang
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Reconstituted Lipoprotein Particles to Rescue Lipid Defects in the Alzheimer's Brain

Technology / Case number: #25445P
Li-Huei Tsai / Rebecca Pinals
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Method of Enhanced Clearance of Uremic Toxins in Hemodialysis using Nanoporous Membranes

Technology / Case number: #21853
Rohit Karnik / Aaron Persad / Chun Man Chow / Chi Cheng
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Optimized Alum-Anchored HIV Env Immunogens

Technology / Case number: #24972HJ
Kristen Rodrigues / Christopher Cottrell / Jon Steichen / William Schief / Darrell Irvine
Technology Areas: Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Magnetic Transmissions for a Catapulting Actuator

Technology / Case number: #21768
Marcel Thomas / Martin Culpepper
Technology Areas: Energy & Distribution / Industrial Engineering & Automation
Impact Areas: Sustainable Future
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Current Rectifiers Based on Noncentrosymmetric Quantum Materials

Technology / Case number: #20996
Pablo Jarillo-Herrero / Qiong Ma / Liang Fu / Nuh Gedik / Suyang Xu / Hiroki Isobe
Technology Areas: Chemicals & Materials / Communication Systems / Energy & Distribution
Impact Areas: Connected World, Advanced Materials
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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