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Open-Ended, Dicer-Cleavable Concatemeric siRNA Generated by Rolling Circle Transcription

Technology / Case number: #18076
Connie Wu / Kevin Shopsowitz / Paula Hammond
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Development of Multi-Specific Antibody-Serum Albumin Fusion Proteins Targeting Multiple Human and Murine CXC (ELR+) Chemokines

Technology / Case number: #19355JQ
Alessandro Angelini / Andrew Luster / Karl Wittrup
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Delivery of Preassembled Double-Stranded Short Interference RNA-Argonaute Protein Complexes for Enhanced RNAi-Based Therapeutics

Technology / Case number: #19340
Jiahe Li / Yanpu He / Wade Wang / Paula Hammond
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Uncharted Frontiers
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Discovery of Self-Labeling Miniproteins

Technology / Case number: #18742
Bradley Pentelute / Ethan Evans
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Uncharted Frontiers, Advanced Materials
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Structured DNA Conjugates

Technology / Case number: #18588
Mark Bathe / Sakul Ratanalert / Remi Veneziano / Tyson Shepherd / Hyungmin Jun
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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N/ASynergistic Tumor Treatment with IL-2, an Integrin-Binding-FC Fusion Protein, and a Cancer Vaccine

Technology / Case number: #18598HJ
Byron Kwan / Cary Opel / Kelly Moynihan / Darrell Irvine / Jennifer Cochran / Karl Wittrup
Technology Areas: Drug Discovery and Research Tools / Therapeutics
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Highly Parallel Enzymatic DNA Synthesis Using Electrowetting Droplet Technology

Technology / Case number: #19620
Mark Bathe / Tyson Shepherd / James Banal / Joseph Berleant
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Methods for Gene Delivery with Papillomaviruses

Technology / Case number: #21704
Omar Abudayyeh / Jonathan Gootenberg
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Removal of Ruthenium-Initiator from Brush-Arm Star Polymers (BASPs) via Core-to-Surface Ring-Opening Methathesis Polymerization (ROMP)

Technology / Case number: #19525
Jeremiah Johnson / Matthew Golder
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Switchable Superconducting Josephson Junction Device for Low Energy Information Storage and Processing

Technology / Case number: #19854
Juan Pedro Cascales Sandoval / Yota Takamura / Jagadeesh Moodera
Technology Areas: Computer Science / Electronics & Photonics
Impact Areas: Sustainable Future, Advanced Materials
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Magnetic Nanodiscs Mediate Remote Magnetomechanical Control of Neural Calcium

Technology / Case number: #20085
Polina Anikeeva / Alexander Senko / Danijela Gregurec / Pooja Reddy
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Advanced Materials
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RNA-Based Regulatory Technologies for Improved miRNA Sensors

Technology / Case number: #19686
Ron Weiss / Kevin Lebo / Jin Huh
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Novel Peptidic Agents for Targeting Chemoresistant Anti-Apoptotic Bfl-1

Technology / Case number: #18607
Amy Keating / Justin Jenson
Technology Areas: Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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End-to-End Deep Learning Approach to Predict Complex Stress and Strain Fields Directly from Microstructural Images

Technology / Case number: #22477
Markus Buehler / Chi Hua Yu / Zhenze Yang
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science / Electronics & Photonics
Impact Areas: Advanced Materials
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A Universal Methodology to Synthesize Diverse Two-Dimensional Heterostructures

Technology / Case number: #18252
Jing Kong / Tomas Palacios / Xi Ling / Yuxuan Lin / Mildred Dresselhaus
Technology Areas: Chemicals & Materials / Computer Science / Electronics & Photonics
Impact Areas: Uncharted Frontiers, Advanced Materials
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Rapid, Point of Care Detection of Neutralizing Antibodies Against A Virus

Technology / Case number: #23068
Hojun Li / Guinevere Connelly
Technology Areas: Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Splicing-Dependent Transcriptional Gene Silencing or Activation

Technology / Case number: #20890
Ana Fiszbein / Christopher Burge
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Uncharted Frontiers
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RNA Scaffolded Wireframe Origami

Technology / Case number: #24153
Mark Bathe / Tyson Shepherd / Molly Parsons
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Mucin-inspired Glycopolymers Can Selectively Kill Vaginal Pathogen Gardnerella Vaginalis Without Impacting Growth of Beneficial Lactobacillus Crispatus

Technology / Case number: #24459
Katharina Ribbeck / Kelsey Wheeler / Caroline Werlang / Laura Kiessling / Spencer Brucks / Liubov Yakovlieva
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Programmable CRISPR-Responsive Smart Materials

Technology / Case number: #21161JY
James Collins / Helena de Puig Guixe / Luis Soenksen Martinez / Max English / Raphael Gayet / Nicolaas Angenent-Mari / Angelo Mao / Peter Q. Nguyen
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living, Advanced Materials
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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