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Using a Genetically Modified Human IPS Line to Screen for Drugs that Prevent or Treat Alzheimer's Disease

Technology / Case number: #26292P
Li-Huei Tsai / TaeHyun Kim / Leyla Akay / Matheus Victor / Masayuki Nakano
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Amplitude Spectroscopy of a Solid-State Artificial Atom

Technology / Case number: #13407L
David Berns / Mark Rudner / Sergio Valenzuela / William Oliver / Leonid Levitov / Terry Orlando / Karl Berggren
Technology Areas: Sensing & Imaging / Therapeutics
Impact Areas: Healthy Living
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Synergisms between Small Molecule Boosters and LNP Formulations Uncovered using High Throughput Screening and Machine Learning

Technology / Case number: #26199J
Giovanni Traverso / Ameya Kirtane / Rajib Dey / Deepak Subramanian
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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LNP Automation Screening System

Technology / Case number: #26217
Ana Jaklenec / Robert Langer / Linzixuan Rhoda Zhang / Xin Yang / Zhiling Zheng
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Discovery and Engineering of Novel Integrases for High-Efficiency Gene Integration

Technology / Case number: #23554
Omar Abudayyeh / Jonathan S. Gootenberg / Lukas Villiger / Justin Lim
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Amorphous Solid Protein Microparticles via Solvent-Based Dehydration

Technology / Case number: #26228
Patrick Doyle / Talia Zheng
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Biodegradable Lipid-Like Materials for Applications in siRNA Delivery

Technology / Case number: #15420
Kathryn Whitehead / Arturo Vegas / Yunlong Zhang / Joseph Dorkin / Robert Langer / Daniel Anderson
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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2-Aminoindole-Class Antimalarials

Technology / Case number: #14097BJ
Ralph Mazitschek / Sameer Urgaonkar / Cassandra Celatka / Dyann Wirth / Roger Wiegand / Mary Lynn Baniecki / Joseph Cortese / Edmund Sybertz / Renato Skerlj / Yibin Xiang / Elyse Bourque / Jon Clardy
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Programmable Insertion Approaches Via Reverse Transcriptase Recruitment

Technology / Case number: #23685
Omar Abudayyeh / Jonathan S. Gootenberg / Lukas Villiger / Kaiyi Jiang
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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1,3,5-triazinane-2,4,6-trione (TNT) Derivatives and Uses Thereof

Technology / Case number: #15446
Delai Chen / Yizhou Dong / Ahmed Eltoukhy / Joseph Dorkin / Akinleye Alabi / Hao Yin / Robert Langer / Daniel Anderson
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Heterocycle-Modified Quinolines for Fluorescence-Based Protein Kinase Sensing

Technology / Case number: #13876
Elvedin Lukovic / Juan Gonzalez Vera / Barbara Imperiali
Technology Areas: Biotechnology / Diagnostics / Therapeutics
Impact Areas: Healthy Living
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Compositions and Methods to Deliver RNA to Extracellular Matrix Producing Cells

Technology / Case number: #25390J
Sho Toyonaga / Theresa Raimondo / Dennis Shi / Daniel Anderson
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Olfactory Receptor-Based Devices

Technology / Case number: #12776TE
Manu Prakash / Andreas Mershin / Brian Cook / Joanke (Johanna) Bikker Graveland / Liselotte Kaiser / Shuguang Zhang / Yael Maguire / David Kong
Technology Areas: Biotechnology / Chemicals & Materials / Computer Science / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Reversible and Ratiometric Sensing using Nanocrystals

Technology / Case number: #11693
Preston Snee / Rebecca Somers / Moungi G Bawendi / Daniel Nocera
Technology Areas: Biotechnology / Diagnostics / Electronics & Photonics / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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An Approach for Enriching the Production of DNA Cargo Loaded AAV5 Capsids in Cells

Technology / Case number: #25585
Paul Barone / Richard D Braatz / Anthony Sinskey / Stacy Springs / Rui Wen Ou / Jacqueline Wolfrum / Prasanna Srinivasan / John Joseph
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Novel Glucose-Responsive Insulin Formulations Using Chemically Modified Insulin Derivatives and Non-Covalent Insulin-Binding Molecules

Technology / Case number: #15976J
Arturo Vegas / Yair Levi / Yunlong Zhang / Benjamin Tang / Hung-Chieh (Danny) Chou / Kun Xue / Matthew Webber / Rosemary Kanasty / Robert Langer / Daniel Anderson
Technology Areas: Chemicals & Materials / Computer Science / Therapeutics
Impact Areas: Healthy Living
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Machine Learning-Guided Discovery of Nanoparticle Formulations Maximizing mRNA Transfection

Technology / Case number: #25890J
Giovanni Traverso / Ameya Kirtane / Joshua Bernstock / Alvin Chan / Jonathan Woo / Deepak Subramanian / Simon Qu / Xisha Huang / Hao Song / Taksim Ahmed
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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A Computational Method for Identifying the Biophysical Interactions that Determine Human T Cell Specificity from Structural Data and Primary Amino Acid Sequences

Technology / Case number: #26026J
Xingcheng Lin / Herbert Levine / José Onuchic / Ailun Wang / Jason George
Technology Areas: Computer Science / Therapeutics
Impact Areas: Healthy Living
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A Novel Injectable Thiol-Acrylate Poly(ethylene Glycol) Hydrogel for Sustained Release of Methylprednisolone Sodium Succinate

Technology / Case number: #14439J
Eric Woodard / Christopher Pritchard / Daniel Siegwart / Timothy O'Shea / Francis Reynolds / Jonathan Slotkin / Robert Langer / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Self Assembled RSV Nanoparticle Vaccines

Technology / Case number: #16549
Vidya Subramanian / Aditya Raguram / Ram Sasisekharan
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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