Reversible Covalent Modification for Improving Protein Delivery

The present disclosure provides compositions and methods for efficient and effective protein delivery in vitro and in vivo. In some aspects, proteins are reversibly crosslinked to each other and/or modified with functional groups and protected from protease degradation by a polymer-based or silica-based nanoshell.

Researchers

Darrell J Irvine / Li Tang

Technology Areas: Drug Delivery: Microparticles & Nanoparticles / Therapeutics: Proteins & Antibodies
Impact Areas: Healthy Living

  • carrier-free biologically-active protein nanostructures
    United States of America | Granted | 9,603,944
  • carrier-free biologically-active protein nanostructures
    United States of America | Granted | 11,529,392
  • carrier-free biologically-active protein nanostructures
    United States of America | Granted | 10,357,544
  • carrier-free biologically-active protein nanostructures
    United States of America | Granted | 10,588,942
  • carrier-free biologically-active protein nanostructures
    United States of America | Granted | 10,226,510

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