Reversible Covalent Modification for Improving Protein Delivery
Invention type: Technology
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Case number: #16581HQ
The present disclosure provides compositions and methods for efficient and effective protein delivery in vitro and in vivo. In some aspects, proteins are reversibly crosslinked to each other and/or modified with functional groups and protected from protease degradation by a polymer-based or silica-based nanoshell.
Researchers
Li Tang
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Darrell Irvine
Departments: Department of Biological Engineering
Technology Areas: Drug Delivery: Microparticles & Nanoparticles / Therapeutics: Proteins & Antibodies
Impact Areas: Healthy Living
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carrier-free biologically-active protein nanostructures
United States of America | Granted | 9,603,944 -
carrier-free biologically-active protein nanostructures
European Patent Convention | Granted | 3,049,114 -
carrier-free biologically-active protein nanostructures
Japan | Granted | 7,097,667 -
carrier-free biologically-active protein nanostructures
Canada | Granted | 2,925,304 -
carrier-free biologically-active protein nanostructures
United States of America | Granted | 10,226,510 -
carrier-free biologically-active protein nanostructures
United States of America | Granted | 10,357,544 -
carrier-free biologically-active protein nanostructures
United States of America | Granted | 10,588,942 -
carrier-free biologically-active protein nanostructures
United States of America | Granted | 11,529,392 -
carrier-free biologically-active protein nanostructures
Japan | Granted | 7,272,664 -
carrier-free biologically-active protein nanostructures
European Patent Convention | Published application -
carrier-free biologically-active protein nanostructures
Belgium | Granted | 3,049,114 -
carrier-free biologically-active protein nanostructures
Germany | Granted | 3,049,114 -
carrier-free biologically-active protein nanostructures
France | Granted | 3,049,114 -
carrier-free biologically-active protein nanostructures
Switzerland | Granted | 3,049,114 -
carrier-free biologically-active protein nanostructures
United Kingdom | Granted | 3,049,114 -
carrier-free biologically-active protein nanostructures
Spain | Granted | 3,049,114 -
carrier-free biologically-active protein nanostructures
Netherlands | Granted | 3,049,114 -
carrier-free biologically-active protein nanostructures
Italy | Granted | 3,049,114 -
carrier-free biologically-active protein nanostructures
United States of America | Published application -
carrier-free biologically-active protein nanostructures
Hong Kong | Published application -
carrier-free biologically-active protein nanostructures
Japan | Published application
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