Reversible Covalent Modification for Improving Protein Delivery
                                                                            Invention type: Technology
                                    
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                                                                            Case number: #16581HQ
                                                                    
                                The present disclosure provides compositions and methods for efficient and effective protein delivery in vitro and in vivo. In some aspects, proteins are reversibly crosslinked to each other and/or modified with functional groups and protected from protease degradation by a polymer-based or silica-based nanoshell.
Researchers
                            
    
    
    Darrell J Irvine
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    Li Tang
                        
                    
                                        Technology Areas: 	Drug Delivery: Microparticles & Nanoparticles  / Therapeutics: Proteins & Antibodies 
                                    
                                
                                                                    
                                        Impact Areas: Healthy Living
                                    
                                                            - 
            carrier-free biologically-active protein nanostructures
United States of America | Granted | 9,603,944 - 
            carrier-free biologically-active protein nanostructures
United States of America | Granted | 11,529,392 - 
            carrier-free biologically-active protein nanostructures
United States of America | Granted | 10,357,544 - 
            carrier-free biologically-active protein nanostructures
United States of America | Granted | 10,588,942 - 
            carrier-free biologically-active protein nanostructures
United States of America | Granted | 10,226,510 
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