Increased Isobutanol Tolerance and Production in Yeast

A method for producing metabolites that are heavy alcohols, and particularly branched-chain alcohols is provided, involving contacting a suitable substrate with recombinant microorganisms. The microorganisms contain at least one deletion, disruptions, or mutations from the GLN gene family, VPS gene family, GNP gene family, AVT gene family, GCN gene family, or YDR391C, and combinations thereof, and overproduce the heavy alcohol as compared to a wild-type yeast strain.

Researchers

Jose Avalos / Sarah Hammer / Kouichi Kuroda / Gregory Stephanopoulos / Gerald Fink

Departments: Department of Chemical Engineering, Department of Biology
Technology Areas: Chemicals & Materials: Composites

  • system and method for increased alcohol tolerance and production in yeast
    United States of America | Published application

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