Katharina Ribbeck

Andrew (1956) and Erna Viterbi Professor

Department
Department of Biological Engineering
Technology Areas
Diagnostics: Assays / Therapeutics: Proteins & Antibodies, Regenerative Medicine, Small Molecules / Chemicals & Materials: Polymers, Composites / Drug Discovery and Research Tools: Cell Lines & Organoids / Biomaterials & Bioelectronics: Medical Device Coatings / Biotechnology: Biomanufacturing, Synthetic Biology, Tissue Engineering

Integrating cross-disciplinary approaches to unravel the properties of mucus and mucosal barriers on pathogen defense and cancer progression

Background and Experience

Professor Ribbeck obtained her Bachelor’s degree and her PhD in Biology from the University of Heidelberg, Germany. She continued her postdoctoral research at the European Molecular Biology Laboratory, Heidelberg, Germany, and the Department of Systems Biology, Harvard Medical School. Katharina Ribbeck established her independent research group as a Bauer Fellow at the FAS Center for Systems Biology, Harvard University in 2007, and joined the Department of Biological Engineering at MIT as an Assistant Professor in 2010.

The Ribbeck Lab’s focus is on basic mechanisms by which mucus barriers exclude, or allow passage of different molecules and pathogens, and the mechanisms pathogens have evolved to penetrate mucus barriers. It hopes to provide the foundation for a theoretical framework that captures general principles governing selectivity in mucus, and likely other biological hydrogels such as the extracellular matrix, and bacterial biofilms. The Lab’s work may also be the basis for the reconstitution of synthetic gels that mimic the basic selective properties of biological gels.

Technologies

Utilizing a Strategic Blend of Block Copolymers to Control Particle Surface Charge for Enhanced Mucus Transport and Tissue Targeting

Technology / Case number: #25439J
Angela Belcher / Brian Wilson / Boris Sevarika / Robert Prud'homme / Corey Alfred Stevens / Katharina Ribbeck
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living
License

Mucin-Inspired Glycopolypeptides for Managing Microbial Infections

Technology / Case number: #26189J
Katharina Ribbeck / Jessica Kramer / Michaela Gold / Kelsey Wheeler
Technology Areas: Therapeutics
Impact Areas: Healthy Living
Labels
  • Women's Health
License

PEG-Lectin Conjugates for Mucin Hydration

Technology / Case number: #15577
Katharina Ribbeck / Thomas Crouzier
Technology Areas: Chemicals & Materials
Impact Areas: Healthy Living
Labels
  • Women's Health
License

Adhesive Hydrogels Composed of Mucin Proteins Crosslinked by Catechol-Thiol Bonds

Technology / Case number: #25402
Gareth McKinley / Corey Alfred Stevens / George Degen / Katharina Ribbeck
Technology Areas: Biomaterials & Bioelectronics / Chemicals & Materials
License

Synthetic Mucin Glycans as Antifungal Agents

Technology / Case number: #24073J
Katharina Ribbeck / Rachel Hevey / Julie Takagi
Technology Areas: Therapeutics
Impact Areas: Healthy Living
Labels
  • Women's Health
License

Mucins as Regulators of Interspecies Microbial Interactions

Technology / Case number: #17408
Katharina Ribbeck / Julia Co / Erica Shapiro / Nicole Kavanaugh
Technology Areas: Diagnostics / Therapeutics
Impact Areas: Healthy Living
Labels
  • Women's Health
License

Mucin-inspired Glycopolymers Can Selectively Kill Vaginal Pathogen Gardnerella Vaginalis Without Impacting Growth of Beneficial Lactobacillus Crispatus

Technology / Case number: #24459
Katharina Ribbeck / Liubov Yakovlieva / Spencer Brucks / Laura L Kiessling / Caroline Werlang / Kelsey Wheeler
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
Labels
  • Women's Health
License

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