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Pooled Screening Identifies Genomic Features (Biomarkers) Modulating Nanoparticle-Cell Interactions

Technology / Case number: #22785J
Angela Koehler / Natalie Boehnke / Joelle Straehla / Paula Hammond
Technology Areas: Diagnostics / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Cationic Lipidoids and Their Uses for Immunotherapy

Technology / Case number: #19803
Linxian Li / Yuxuan Huang / Lei Miao / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Synthesis of Ester, Carbonate, and Carbamate-derived Novel Biodegradable Ionizable Lipids from Methyl Ricinoleate or Methyl 12-Hydroxystearate and its Applications

Technology / Case number: #23381Q
Luke Rhym / Bowen Li / Akiva Gordon / Manan manan / Jacob Witten / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Enhanced Vaccine Immunogenicity Enabled by Targeted Delivery of Tumor Antigens into Dendritic Cells

Technology / Case number: #25054H
Bradley Pentelute / Cameron Hanna / Emi Lutz / Simon Roessler / Nicholas Truex / Aurelie Rondon / Yehlin Cho / Coralie M. Backlund / Binyou Wang / Darrell Irvine
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Lipid Anchorage of Cytokines onto Layer-by-Layer Nanoparticles

Technology / Case number: #25070H
Ivan Susin Pires / Darrell Irvine / Paula Hammond
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Combinations of Anesthetics as Therapies for Treatment-Resistant Depression

Technology / Case number: #25342P
Emery Brown / Sirma Orguc / Ohyoon Kwon / Bryan Tseng / Macauley Breault / Gloria Kang
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Engineered Synthetic IRES with Improved and Robust Translation in Circular RNA

Technology / Case number: #25300YJ
James Collins / Katherine Ilia / Shiva Razavi / Kehan Zhang / Xiaoyu Chen / Makoto Lalwani / Yu Li / Nayoung Kim
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Reconstituted Lipoprotein Particles to Rescue Lipid Defects in the Alzheimer's Brain

Technology / Case number: #25445P
Li-Huei Tsai / Rebecca Pinals
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Cell-Surface Anchored Cytokine Therapy

Technology, Tangible Property / Case number: #25245H
Luciano Santollani / Darrell Irvine / Karl Wittrup
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Spatially Localized Gene Delivery of Adeno-Associated Viruses

Technology / Case number: #25055
Polina Anikeeva / Keisuke Nagao
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Method of Enhanced Clearance of Uremic Toxins in Hemodialysis using Nanoporous Membranes

Technology / Case number: #21853
Rohit Karnik / Aaron Persad / Chun Man Chow / Chi Cheng
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Optimized Alum-Anchored HIV Env Immunogens

Technology / Case number: #24972HJ
Kristen Rodrigues / Christopher Cottrell / Jon Steichen / William Schief / Darrell Irvine
Technology Areas: Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Selective Valorization of Biomass Sugars

Technology / Case number: #21846
Alison Wendlandt / Yong Wang / Hayden Carder
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Biodegradable Lipids and Formulations for Intramuscular, In Vitro, and Ex Vivo Transfection of mRNA

Technology / Case number: #23969J
Arnab Rudra / Akash Gupta / Kaelan Reed / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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A Diagnostic and Treatment Prediction Toolkit for Bipolar Disorder based on Polymorphisms in CPG2 Regulatory Domains

Technology / Case number: #23591P
Baovi Vo / Elly Nedivi
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Functionalization of MiniHA with Lauric Acid

Technology / Case number: #20135
Bradley Olsen / Allie Obermeyer / Sieun Kim / Lavinia Popescu / Yun Jung Yang
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Thermogelling Nanoemulsions for Pharmaceutical Manufacturing

Technology / Case number: #22768
Patrick Doyle / Liang-Hsun Chen
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Novel Chimeric Antigen Receptor Signaling Domains Derived via Activity-based Directed Evolution

Technology / Case number: #21116
Michael Birnbaum / Taeyoon Kyung
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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A Ribonucleoprotein Approach to Boost the STING Signaling for Cancer Immunotherapy

Technology / Case number: #21216
Jiahe Li / Yanpu He / Paula Hammond
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Using Cross-Dressing to Enhance Anti-Tumor Immune Responses

Technology / Case number: #21679
Stefani Spranger / Ellen Duong
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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