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Characterization and Utilization of a Subgenomic Promoter Mutant Library for Tuning Expression of Multiple Transgenes from Alphavirus Replicons

Technology / Case number: #21309
Ron Weiss / Jin Huh
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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MicroRNA-based Logic Gates that Do Not Use Exogenous Proteins

Technology / Case number: #21334
Ron Weiss / Giulio Alighieri
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Endogenous Gene Sensing and Actuation by Placement of Non-Coding RNA after Transcriptional Termination Signals

Technology / Case number: #21520
James Collins / Ron Weiss / Jeremy Gam / Elvira Vitu / Casper Enghuus
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Carbon Nanoparticles for use as a Vehicle to Target and Treat Macrophages, and Macrophage RNF41 as a Molecule Essential to Switch Macrophage Phenotype

Technology / Case number: #22023
Elazer Edelman / Pedro Melgar Lesmes
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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High-Throughput Expansion Microscopy

Technology / Case number: #22339
Laurie Boyer / Edward Boyden / Pema Maretich / Alexander Auld / John Day / Catherine Della Santina
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Simultaneous Delivery of Cancer Treatment Programs to Tumor and Immune Cells

Technology / Case number: #22351
Ron Weiss / Jin Huh / Yingzhong Li
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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M13 Bacteriophage with a High Cysteine Content and Genetically Engineerable Hydrogels

Technology / Case number: #22369
William Records / Nimrod Heldman / Angela Belcher
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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Multicellular Integrated Brain Tissue for Investigation and Therapeutic Discovery in Neurological Diseases

Technology / Case number: #22618P
Li-Huei Tsai / Joel Blanchard / Robert Langer / Alice Stanton / Adele Bubnys
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Perfusable Host Microfluidic Endothelial Networks for Spheroid and Organoid Co-culture and Immune Cell Infiltration Studies

Technology / Case number: #22749
Roger Kamm / Huu Tuan Nguyen / Sharon Lee
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Fusion Capsid Therapy for COVID-19 and Applies to Other Viruses: Universal "Dominant" Antiviral to Prevent Virus Evolution and Future Pandemics (DNA/RNA/Protein)

Technology, Tangible Property / Case number: #22801MH
Edward Boyden / Robert Langer / Alexi Choueiri / Yong Qian / Bowen Li / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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A Tunable Phosphorylation-based Feedback Controller of Mammalian Gene Expression

Technology / Case number: #22932
Ron Weiss / Ross Jones / Domitilla Del Vecchio / Yili Qian
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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A Fluidic Platform for Perfusable Vascularized Tumor Spheroids and Organoids

Technology / Case number: #22942
Roger Kamm / Zhengpeng Wan / Shun Zhang
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Lectin Fingerprinting for Mapping Viral Glycosylation and Identifying Neutralizing Antibodies

Technology / Case number: #22955
Laura Kiessling / Michael Wuo / Amanda Dugan
Technology Areas: Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Lung-Cancer Specific T Cell Dysfunction

Technology / Case number: #23004
John Love / Stefani Spranger / Brendan Horton / Duncan Morgan / Karl Wittrup
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Identification of Genes and Mutations that Underlie Adaptation of Gut Microbes to Denovo Degradation of Oxalate

Technology / Case number: #23007
Jeff Gore / Avihu Yona
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Multi-Input miRNA Sensing with Constitutive ERNs to Regulate Multi-Output Gene Expression in Mammalian Cells

Technology / Case number: #23123
Ron Weiss / Deepak Mishra / Erez Pery / Wenlong Xu / Lei Wang
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Lipid Nanoparticles for Drug Delivery to Microglia in the Brain

Technology / Case number: #23156P
Li-Huei Tsai / Owen Fenton / Joel Blanchard / Robert Langer / Jason Andresen / Julia Bonner / William Ralvenius
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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M13 Phage based Gene Therapy Platform (Chapter 4 of Thesis Work)

Technology / Case number: #23296
Uyanga Tsedev / Angela Belcher
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Organogels for Epidermal Drug Delivery

Technology / Case number: #23303J
Xuanhe Zhao / Xinyue Liu / Xiaoyu Chen / Weibo Wang
Technology Areas: Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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A Fabrication-Free Microfluidic Device for Scalable, High-Volume Bacterial Electroporation

Technology / Case number: #23552
Cullen Buie / Po-Hsun Huang / Sijie Chen
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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