Label-Free Detection of Oligonucleotide Hybridization Using Anchored Single-Walled Carbon Nanotube Corona Phase

The present invention provides a system and method for detecting an analyte in a sample comprising semiconducting single-walled carbon nanotubes (SWCNTs) and surface- adsorbed nucleic acids, wherein the surface-adsorbed nucleic acids comprise a complementary region and at least one anchor, wherein the complementary region comprises a nucleic acid sequence that is complementary' to and/or hybridizes to a target region of the analyte, and the at least one anchor comprises a nucleic acid sequence that is not complementary' to the target region of the analyte.