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AO mRNA-LNP Stabilization

Technology / Case number: #26266
Ana Jaklenec / Robert Langer / Linzixuan Rhoda Zhang / Jooli Han / Tina Huang
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Compact, Planar Transient Grating Spectroscopy System

Technology / Case number: #25473
Michael Short / Jonas Rajagopal / Benjamin Dacus / Angus Wylie
Technology Areas: Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living, Sustainable Future
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Optical Ising Machine and Optical Convolutional Neural Networks

Technology / Case number: #19700
Scott Skirlo / Yichen Shen / Tena Dubcek Varga / Li Jing / Charles Roques-Carmes / Hengameh Bagherianlemraski / Marin Soljacic
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Communication Systems / Sensing & Imaging
Impact Areas: Connected World
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Prolonged-Release Hydrogel Formulations of Toll-Like Receptor Agonists for Intratumoral Injection to Increase Immunotherapy Response

Technology / Case number: #23215J
Giovanni Traverso / Robert Langer / Arijit Basu / Avik Som / Jan-Georg Rosenboom / Gabrielle Ndakwah / Eric Wehrenberg-Klee / Umar Mahmood
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Smart Injection Needle System for Accurate Characterization of Cell Types, Concentrations, and Viability

Technology / Case number: #24367J
Giovanni Traverso / Fangzhou Xia / Kamal Youcef-Toumi / Adam Gierlach / Kewang Nan / Yiyuan Yang / Ming Zhao
Technology Areas: Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living
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Plk1 inhibitor and Microtubule Poison Dual Payload Antibody Drug Conjugates for the Treatment of Cancer

Technology / Case number: #26136
Jesse C Patterson / Michael Yaffe
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Lipid-Polymer Microparticles (mLPM) For Thermostable, Pulsatile mRNA-LNP Vaccines

Technology / Case number: #26154
Ana Jaklenec / Robert Langer / Linzixuan Rhoda Zhang / Yuting Huang
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Polymeric Core-Shell Particles for Pulsatile Release of HIV Vaccine

Technology / Case number: #26230
Ana Jaklenec / Robert Langer / Maria Kanelli / Behnaz Eshaghi / Amy Lee / Rishi Das / Aki Gurram / Stacey Lin
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Branched Poly(-amino esters) for the Delivery of Nucleic Acids

Technology / Case number: #20333JQ
Giovanni Traverso / Yunhua Shi / Ameya Kirtane / Grace Junyue Zhong / Daniel Reker / Robert Langer / Hyunjoon Kim / Netra Kamat / James Byrne / Gary Liu
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Amino Acid, Peptide, Polypeptide-Lipids (APPL) Derivatives and Uses Thereof

Technology / Case number: #14910Q
Kevin Love / Arturo Vegas / Delai Chen / Yi Chen / Yizhou Dong / Yunlong Zhang / Akinleye Alabi / Robert Langer / Daniel Anderson
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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An Ultra-Wide-Band-Gap Semiconductor Optical Switch that is Capable of Fast Turn-Off and Achieves High Current Density with Visible Light at Low Irradiance

Technology / Case number: #26249
Rafael Jaramillo / Jiahao Dong
Technology Areas: Electronics & Photonics / Sensing & Imaging
Impact Areas: Advanced Materials
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A MEMS Based Encapsulated Hydrophone

Technology / Case number: #26013LJ
Daniel Freeman / Robert White / Jonathan Anderson / Georgios Karamanis / James Vlahakis
Technology Areas: Chemicals & Materials / Electronics & Photonics / Industrial Engineering & Automation / Sensing & Imaging
Impact Areas: Sustainable Future, Connected World
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All-Optical Three-Dimensional Compression of Electron Pulses for Ultrafast Electron Imaging

Technology / Case number: #17343
Liang Jie Wong / Nuh Gedik / Timm Rohwer / Byron Freelon / Steven G Johnson
Technology Areas: Chemicals & Materials / Communication Systems / Sensing & Imaging
Impact Areas: Connected World, Advanced Materials
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Scale-Cascaded Coalescence

Technology / Case number: #15750L
Sai Ravela
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Sensing & Imaging
Impact Areas: Connected World
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Expression Constructs for One-Step Construction of Allogeneic CAR-NK Cells

Technology, Tangible Property / Case number: #26118J
Rizwan Romee / Fuguo Liu / Jianzhu Chen
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Connected World
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Reprogram the Genome of M13 Phage for Vaccination and Immunotherapy Applications

Technology / Case number: #25169
Shengnan Huang / Angela Belcher
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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A Mechanical Underwater Soft Adhesion System for Kinetic Biosensing and Intelligent Targeted Drug Delivery

Technology / Case number: #26028J
Giovanni Traverso / Ameya Kirtane / Ming Zhao / Troy Ziliang Kang / Yubin Cai
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Organic Indoor Location Discovery

Technology / Case number: #13472J
Jonathan Battat / Benjamin Charrow / David Lambeth / Jonathan Ledlie / James Hicks / Seth Teller / Dorothy Curtis
Technology Areas: Communication Systems / Sensing & Imaging
Impact Areas: Connected World
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Method to Improve the Image Quality of Positron Emission Tomography When Using Non-Standard Isotopes Based on Triple Coincidences

Technology / Case number: #16135
Shivang Dave / Vicente Parot / Eduardo Lage / Joaquin Herraiz
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Communication Systems / Electronics & Photonics / Sensing & Imaging
Impact Areas: Healthy Living
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Method for Quantitative Monitoring of In Vivo Tumor Oxygenation

Technology / Case number: #19207JQ
Michael Cima / Gregory Ekchian / Larissa Lee / Robert Cormack / Ehud Schmidt
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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