Paul Barone

Co-Director, Biomanufacturing Program

Department
Center for Biomedical Innovation
Technology Areas
Biotechnology: Biomanufacturing, Synthetic Biology, DNA & RNA Editing, Sensors & Monitoring / Drug Delivery: Vectors & Virus like Particles / Therapeutics: Nucleic Acids, Proteins & Antibodies, Cell Based Therapy, Regenerative Medicine / Chemicals & Materials: Nanotechnology & Nanomaterials / Drug Discovery and Research Tools: Antibodies, Genomics & Proteomics / Sensing & Imaging: Optical Sensing, Chemical & Radiation Sensing

Background and Experience

Dr. Barone has been at the Massachusetts Institute of Technology’s Center for Biomedical Innovation (CBI) since 2010 where he is currently the Director of the Consortium on Adventitious Agent Contamination in Biomanufacturing (CAACB) a pre-competitive biopharmaceutical industry consortium focused on identifying and sharing best practices to mitigate the risk of adventitious agent contamination in biopharmaceutical manufacturing. Dr. Barone is also the Co-Director of Biomanufacturing@MIT-CBI, where he manages a variety of sponsored research activities related to biopharmaceutical manufacturing, including the development of novel analytical technologies for the rapid assessment of protein product quality, the development of a process for the continuous production of viral vectors, and the development of an online course on the principles of cell therapy manufacturing.

Technologies

An Approach for Enriching the Production of DNA Cargo Loaded AAV5 Capsids in Cells

Technology / Case number: #25585
Anthony Sinskey / John Joseph / Prasanna Srinivasan / Jacqueline Wolfrum / Rui Wen Ou / Stacy Springs / Richard D Braatz / Paul Barone
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
License

Single-Walled Carbon Nanotube Based Hydrogels for In Vivo Glucose Detection

Technology / Case number: #13588
Michael S. Strano / Hyeonseok Yoon / Rene Ortiz Garcia / Ardemis Boghossian / Jin Ho Ahn / Jingqing Zhang / Paul Barone
Technology Areas: Biotechnology / Chemicals & Materials / Sensing & Imaging
License

A Synthetic Nanotube Antibody for Selective Molecular Recognition

Technology / Case number: #14090
Michael S. Strano / Jingqing Zhang / Daniel Heller / Paul Barone / Jong Ho Kim
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Healthy Living
License

A Single-Walled Carbon Nano-Tube/Chitosan Hydrogel Array for the Label-Free, Optical Detection of Protein-Protein Interactions

Technology / Case number: #14201
Michael S. Strano / Nigel Reuel / Jin Ho Ahn / Paul Barone / Jong Ho Kim
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Sensing & Imaging / Therapeutics
Impact Areas: Healthy Living
License

Encapsulation Forms and Modulation Chemistries for Ratiometric, Internally Calibrated Near Infrared Fluorescent Single-Walled Carbon Nanotube Sensor for Reversible Glucose Detection

Technology / Case number: #14887
Michael S. Strano / Thomas McNicholas / Kyungsuk Yum / Jin Ho Ahn / Paul Barone
Technology Areas: Chemicals & Materials / Sensing & Imaging
License

Preferential Crystallization of fullrAAVs in a Hanging Drop Crystallizer as an Alternative Method for Downstream Purification of rAAV-based Gene Therapies

Technology / Case number: #24870
Anthony Sinskey / Vivekananda Bal / Moo Sun Hong / Stacy Springs / Richard D Braatz / Paul Barone
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

Sign up for technology updates

Sign up now to receive the latest updates on cutting-edge technologies and innovations.