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Slow Delivery of Antigen and Adjuvant Plus A Delayed Boost for Unexpected Immunogenicity

Technology / Case number: #23762HJ
Darrell J Irvine / Shane Crotty
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Intranasal amphiphile-protein conjugate vaccine

Technology / Case number: #23991H
Darrell J Irvine / Brittany Hartwell
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Tandem Peptide Approaches for Delivery to Gram-Negative Bacteria

Technology / Case number: #19017H
Sangeeta Bhatia / Leslie Chan / Ester Kwon
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Locally Delivered Therapeutics and Combinations for Expedited Passage of Urinary Stones

Technology / Case number: #19454JQ
Michael Cima / Brian Eisner / Xiang Li
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Mammalian Synthetic Biology Approaches for the Precise Control of mAb N-Glycosylation (Pfizer-MIT PTM Track 2 Interim Joint Summary Document)

Technology / Case number: #19972J
Timothy K Lu / Bruno Figueroa / John Scarcelli / Jeffrey Marshall / Richard Cornell / Giyoung Jung / Michelle Chang / Leonid Gaidukov / Wen Tseng / Nevin Summers / Ron Weiss
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Enhanced Endogenous Recombination for Gene Therapy and Genetic Engineering

Technology / Case number: #20008M
Guoping Feng / Qiangge Zhang / Martin Wienisch / Tomomi Aida / Jonathan Wilde
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Miniaturized Sample Holder for Multi-Axial Testing and Multi-Probe Microstructure Tracking

Technology / Case number: #20155
Emeric Plancher / C. Cem Tasan / Ke Qu / Nicolaas Vonk
Technology Areas: Agriculture & Food / Sensing & Imaging
Impact Areas: Healthy Living
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Gastric-Resident Devices for Gram-level Drug Delivery

Technology / Case number: #20379JQ
Robert Langer / Daniel Minahan / Taylor Bensel / Malvika Verma / Tyler Grant / Andrew Bellinger / Giovanni Traverso
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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1. Methods for in Vitro Evolution of Constructs Derived from Viruses. 2. Five Mutations Derived from the in Vitro Evolution. 3. Seventeen constructs from the five mutations.

Technology / Case number: #20395H
Darrell J Irvine / Yingzhong Li / Ron Weiss
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Activatable Antimicrobial Peptides and Uses Thereof

Technology / Case number: #24024H
Sangeeta Bhatia / Chayanon Ngambenjawong
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Fabrication of Polymeric Microneedles with Hollow and Porous Tips via a Simple Micromolding Process Assisted by Ionic Salts

Technology / Case number: #24093
Benedetto Marelli / Doyoon Kim
Technology Areas: Agriculture & Food / Chemicals & Materials
Impact Areas: Advanced Materials
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Adhesive, Injectable Hydrogels for Local Therapy Delivery to Brain Tumors

Technology / Case number: #24170JQ
Natalie Artzi / Dahis Daniel / Michelle Dion
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Universal Redirection of Chimeric Antigen Receptor T Cells Against Solid Tumors via Tumor Cell Membrane-Inserting CAR Ligands

Technology / Case number: #24270H
Darrell J Irvine / Alexander Hostetler / Laura Chen / Angela Zhang
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Programmable Immunostimulation with Structured DNA Nanoparticles

Technology / Case number: #24273H
Darrell J Irvine / Benjamin Read / Eike-Christian Wamhoff / Tyson Moyer / Rebecca Du / Remi Veneziano / Mark Bathe
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Compositions for the Conditional Delivery of Macromolecules and Combination Therapeutics

Technology / Case number: #24492H
Sangeeta Bhatia / Qian Zhong / Edward Tan / Chayanon Ngambenjawong
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Autocatalytic Base Editing for RNA-Responsive Translational Control

Technology / Case number: #24552YJ
James Collins / Makoto Lalwani / Jonathan C. Chen / Xiaoyu Chen / Kehan Zhang / Nathaniel Tippens / Shiva Razavi / Katherine Ilia / Raphael Gayet
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Targeted Layered Lipid Nanoparticles for in Vivo Extrahepatic Gene Delivery

Technology / Case number: #24751
Paula Hammond / Tamara Dacoba / Namita Nabar
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Modulating Oncogenic Transcriptional Dysregulation with Small Molecule Chimeric Degraders of Cyclin-Dependent Kinase 9

Technology / Case number: #24831
Angela Koehler / Keisuke Motoyama / Mohammed Toure
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Pollen-Like Microstructures

Technology / Case number: #24869
Benedetto Marelli / Muchun Liu
Technology Areas: Agriculture & Food / Chemicals & Materials
Impact Areas: Sustainable Future, Advanced Materials
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Preferential Crystallization of fullrAAVs in a Hanging Drop Crystallizer as an Alternative Method for Downstream Purification of rAAV-based Gene Therapies

Technology / Case number: #24870
Anthony Sinskey / Vivekananda Bal / Moo Sun Hong / Stacy Springs / Richard D Braatz / Paul Barone
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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