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M13 Phage Assembly System for Optimal Blood Trafficking, Tumor Penetration, and Passage Across the Blood Brain Barrier

Technology / Case number: #19438
Uyanga Tsedev / Fred Lam / Angela Belcher
Technology Areas: Drug Delivery / Sensing & Imaging / Therapeutics
Impact Areas: Healthy Living
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Multiplexed Specific Metalloprotease Activity Measurements

Technology / Case number: #19425DE
Miles Miller / Caroline Chopko Ahrens / Christi Cook / Steven Tannenbaum / Ravindra Kodihalli / Evan Chiswick / Linda Griffith / Douglas Lauffenburger
Technology Areas: Biomaterials & Bioelectronics / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Open-Ended, Dicer-Cleavable Concatemeric siRNA Generated by Rolling Circle Transcription

Technology / Case number: #18076
Connie Wu / Kevin Shopsowitz / Paula Hammond
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Development of Multi-Specific Antibody-Serum Albumin Fusion Proteins Targeting Multiple Human and Murine CXC (ELR+) Chemokines

Technology / Case number: #19355JQ
Alessandro Angelini / Andrew Luster / Karl Wittrup
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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A Biomedical Imaging and Optical Stimulation Device

Technology / Case number: #18022
Juejun Hu / Tian Gu / Qi Qin
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living
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Diazene Directed Modular Synthesis of Oligocyclotryptamines

Technology / Case number: #18747
Mohammad Movassaghi / Petra Lindovska
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers, Advanced Materials
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Discovery of Self-Labeling Miniproteins

Technology / Case number: #18742
Bradley Pentelute / Ethan Evans
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Uncharted Frontiers, Advanced Materials
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Noncontact Power Sensing

Technology / Case number: #18553
James Paris / John Donnal / David Lawrence / Steven Leeb
Technology Areas: Energy & Distribution
Impact Areas: Sustainable Future
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Manufacture of Thermo-Responsive Hydrogel Composing of Drug-Nanocapsule for Sustainable Release of Ibuprofen, Ofloxacin and Dexamethasone

Technology / Case number: #18561
Jeremiah Johnson / Qixian Chen / Farrukh Vohidov
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Structured DNA Conjugates

Technology / Case number: #18588
Mark Bathe / Sakul Ratanalert / Remi Veneziano / Tyson Shepherd / Hyungmin Jun
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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N/ASynergistic Tumor Treatment with IL-2, an Integrin-Binding-FC Fusion Protein, and a Cancer Vaccine

Technology / Case number: #18598HJ
Byron Kwan / Cary Opel / Kelly Moynihan / Darrell Irvine / Jennifer Cochran / Karl Wittrup
Technology Areas: Drug Discovery and Research Tools / Therapeutics
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Enhancing tumor immunogenicity with Hsp90 inhibition

Technology / Case number: #20303WHJ
Luke Whitesell / Alexander Jaeger / Sandro Santagata / Tyler Jacks / Susan Lindquist
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Layer-by-Layer Nanoparticles for Cytokine Therapy in Cancer Treatment

Technology / Case number: #20027H
Erik Dreaden / Mariane Melo / Antonio Barberio / Santiago Correa Echavarria / Talar Tokatlian / Darrell Irvine / Paula Hammond
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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New Methods to Assess Fluid Distribution in Muscle Tissue via Single Sided Magnetic Resonance Sensors

Technology / Case number: #21335
Michael Cima / Ashvin Bashyam / Christopher Frangieh
Technology Areas: Biotechnology / Diagnostics
Impact Areas: Healthy Living
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Methods and Compositions for Increasing Sensitivity of Cancer Cells to Glutaminase Inhibitors and Applications to Cancer Therapy

Technology / Case number: #19305
Matthew Vander Heiden / Dan Gui / Alexander Muir / Laura Danai
Technology Areas: Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Intracellular Calcium Sensors for MRI

Technology / Case number: #20143
Ali Barandov / Benjamin Bartelle / Alan Jasanoff
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living, Uncharted Frontiers
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Dendrimer Drug Conjugates for Sustained Intra-Articular Delivery

Technology / Case number: #19214
Brett Geiger / Paula Hammond
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Methods for Gene Delivery with Papillomaviruses

Technology / Case number: #21704
Omar Abudayyeh / Jonathan Gootenberg
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors

Technology / Case number: #19540J
Jeremiah Johnson / Hung Nguyen / Andrzej Rajca
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living
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Removal of Ruthenium-Initiator from Brush-Arm Star Polymers (BASPs) via Core-to-Surface Ring-Opening Methathesis Polymerization (ROMP)

Technology / Case number: #19525
Jeremiah Johnson / Matthew Golder
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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