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Micro-Invasive Neural System for Delivering Antiseizure Medications to the Epileptic Focus for the Treatment of Refractory Epilepsy

Technology / Case number: #25721J
Michael Cima / Max Cotler / Hannah Jackson / Cameron Metcalf / Karen Wilcox / Peter West
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Non-Surgical Biomedical Implants

Technology / Case number: #25352TE
Deblina Sarkar / Shubham Yadav
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living, Uncharted Frontiers, Advanced Materials
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Single-Step Insertion into Repeated Regions for Efficient Multi-Locus Assortment and Daisyfield Drive

Technology / Case number: #19136TJE
Kevin Esvelt / Jianghong Min / Charleston Noble
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Uncharted Frontiers
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Closed-Loop Ingestible Robot for Radiation and Chemical Sensing

Technology / Case number: #22735
Giovanni Traverso / Hen Wei Huang / James Byrne
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Industrial Engineering & Automation / Sensing & Imaging
Impact Areas: Healthy Living, Uncharted Frontiers
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Clockwise Learning Task

Technology / Case number: #25128M
Georgios Papageorgiou / Ann M. Graybiel
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Uncharted Frontiers
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Intrinsically Stretchable Microelectronic Fibers and Their Assemblies as Multifunctional Bioelectronic Interfaces for Whole Organs

Technology / Case number: #24178
Polina Anikeeva / Atharva Sahasrabudhe / Rajib Mondal
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living, Uncharted Frontiers, Advanced Materials
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Single Cell Super-Resolution Proteomics

Technology / Case number: #24088
Mark Harnett / Dimitra Vardalaki
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living, Uncharted Frontiers
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Synthetic Gene Circuits and Parts in Bacteroides

Technology / Case number: #17815
Timothy K Lu / Mark Mimee / Christopher Voigt / Alex Tucker
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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A Platform for Continuous Directed Evolution in Human Cells

Technology / Case number: #19909
Matthew D. Shoulders / Louis Papa / Christopher Moore / Chet Berman / Samuel Hendel
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Delivery of Preassembled Double-Stranded Short Interference RNA-Argonaute Protein Complexes for Enhanced RNAi-Based Therapeutics

Technology / Case number: #19340
Jiahe Li / Yanpu He / Wade Wang / Paula Hammond
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Uncharted Frontiers
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Discovery of Self-Labeling Miniproteins

Technology / Case number: #18742
Bradley L. Pentelute / Ethan Evans
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Uncharted Frontiers, Advanced Materials
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Intracellular Calcium Sensors for MRI

Technology / Case number: #20143
Ali Barandov / Benjamin Bartelle / Alan Pradip Jasanoff
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living, Uncharted Frontiers
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Methods for Gene Delivery with Papillomaviruses

Technology / Case number: #21704
Omar Abudayyeh / Jonathan S. Gootenberg
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Novel Peptidic Agents for Targeting Chemoresistant Anti-Apoptotic Mcl-1

Technology / Case number: #17695J
Amy Keating / Raheleh Rezaei Araghi / Greg Bird / Loren Walensky
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers, Advanced Materials
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Streptococcus Canis Cas9 for Tunable Genome Engineering and Regulation

Technology / Case number: #19757XTE
Noah Jakimo / Pranam Chatterjee / Joseph Jacobson
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Uncharted Frontiers, Sustainable Future
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Fine-Tuning pKa's of Nucleoside Analogs to Increase Mutagenicity; a Strategy to Develop More Potent Lethal Mutagen with Anti-Viral or Anticancer Properties

Technology / Case number: #17657
Andrei Tokmakoff / John M Essigmann / Bogdan I Fedeles / Vipender Singh / Sam Peng
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers, Advanced Materials
License

Splicing-Dependent Transcriptional Gene Silencing or Activation

Technology / Case number: #20890
Ana Fiszbein / Christopher B Burge
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Uncharted Frontiers
License

The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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