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Engineering Microbes and Metabolic Pathways for the Production of Ethylene Glycol from Xylose, Glucose, Carbohydrates and Renewable Resources

Technology / Case number: #15064
Gregory Stephanopoulos / Jose Avalos / Marjan De Mey / Brian Pereira / Deepak Dugar
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Environmental Engineering
Impact Areas: Sustainable Future, Advanced Materials
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The Design of DNA-scaffolded Subunit Vaccines for Enhanced Germinal Center Responses in HIV Vaccination

Technology / Case number: #25982H
Darrell J Irvine / Anna Romanov / Grant Knappe / Mark Bathe
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Advanced Materials
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Genomic Insertion of Large Cargo with Engineered Retro Elements

Technology / Case number: #23248
Omar Abudayyeh / Justin Lim / Lukas Villiger / Jonathan S. Gootenberg
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Full-field Optical Coherence Microscopy System Using a Digital Focal Plane Array

Technology / Case number: #24144LJ
Guillermo Tearney / Michael Bradshaw / Osman Ahsen / Matthew Johnson / Joseph Gardecki
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Advanced Materials
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Single-Step Insertion into Repeated Regions for Efficient Multi-Locus Assortment and Daisyfield Drive

Technology / Case number: #19136TJE
Kevin Esvelt / Charleston Noble / Jianghong Min
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Uncharted Frontiers
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Frameshift Suppressor tRNAs for Canonical Amino Acids

Technology / Case number: #21418TREJ
Kevin Esvelt / Ahmed Badran / Erika Alden DeBenedictis
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Advanced Materials
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Dissolvable Microcarriers for Adherent Cell Culture

Technology / Case number: #22052JDE
Krystyn Van Vliet / Ee Xien Ng
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Advanced Materials
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Ingestible Chemical Energy Harvesting System with Extended Lifetime

Technology / Case number: #23174
Giovanni Traverso / So-Yoon Yang / Jason Li
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Energy & Distribution / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Engineering a Swine Macro-Organ Colorectal Cancer Platform to Combat Transport-Induced Chemotherapy Resistance

Technology / Case number: #22864JQ
Robert Langer / Daniel Reker / Vance Soares / Yunhua Shi / Giovanni Traverso
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Synthesis of Ester, Carbonate, and Carbamate-derived Novel Biodegradable Ionizable Lipids from Methyl Ricinoleate or Methyl 12-Hydroxystearate and its Applications

Technology / Case number: #23381Q
Daniel Anderson / Jacob Witten / rajith manan / Akiva Gordon / Bowen Li / Luke Rhym
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Clockwise Learning Task

Technology / Case number: #25128M
Ann M. Graybiel / Georgios Papageorgiou
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Uncharted Frontiers
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Biodegradable Lipids and Formulations for Intramuscular, In Vitro, and Ex Vivo Transfection of mRNA

Technology / Case number: #23969J
Daniel Anderson / Kaelan Reed / Akash Gupta / Arnab Rudra
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Dielectric Films for the Control of Cell Adhesion

Technology / Case number: #23881
Kripa K Varanasi / Sophia Sonnert / Baptiste Blanc / Victor Leon
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Advanced Materials
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In Solution Monoclonal Polony Generation on Inorganic Nanoparticle

Technology / Case number: #25039
Ashwin Gopinath / Emily Wu / Nayan Agarwal
Technology Areas: Chemicals & Materials / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Advanced Materials
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Redox-Electrodes for Electrochemically-Controlled Bio-Macromolecule Interaction: Bio-Separations, Heterogeneous Enzyme Immobilization, Protein Purification and Sensing, Among Others

Technology / Case number: #18540
T. Alan Hatton / Xiao Su
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Environmental Engineering
Impact Areas: Sustainable Future, Advanced Materials
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Single Cell Super-Resolution Proteomics

Technology / Case number: #24088
Mark Harnett / Dimitra Vardalaki
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living, Uncharted Frontiers
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A Platform for Continuous Directed Evolution in Human Cells

Technology / Case number: #19909
Matthew D. Shoulders / Samuel Hendel / Chet Berman / Christopher Moore / Louis Papa
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Discovery of Self-Labeling Miniproteins

Technology / Case number: #18742
Bradley L. Pentelute / Ethan Evans
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Uncharted Frontiers, Advanced Materials
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Methods for Gene Delivery with Papillomaviruses

Technology / Case number: #21704
Omar Abudayyeh / Jonathan S. Gootenberg
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Novel Peptidic Agents for Targeting Chemoresistant Anti-Apoptotic Mcl-1

Technology / Case number: #17695J
Amy Keating / Loren Walensky / Greg Bird / Raheleh Rezaei Araghi
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers, Advanced Materials
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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