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Targeted Trans-splicing Using CRISPR-Cas Systems

Technology / Case number: #20505ER
Jacob Borrajo
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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A Mechanical Underwater Soft Adhesion System for Kinetic Biosensing and Intelligent Targeted Drug Delivery

Technology / Case number: #26028J
Giovanni Traverso / Ameya Kirtane / Ming Zhao / Troy Ziliang Kang / Yubin Cai
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Olfactory Receptor-Based Devices

Technology / Case number: #12776TE
Manu Prakash / Andreas Mershin / Brian Cook / Joanke (Johanna) Bikker Graveland / Liselotte Kaiser / Shuguang Zhang / Yael Maguire / David Kong
Technology Areas: Biotechnology / Chemicals & Materials / Computer Science / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Reversible and Ratiometric Sensing using Nanocrystals

Technology / Case number: #11693
Preston Snee / Rebecca Somers / Moungi G Bawendi / Daniel Nocera
Technology Areas: Biotechnology / Diagnostics / Electronics & Photonics / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Machine Learning-Guided Discovery of Nanoparticle Formulations Maximizing mRNA Transfection

Technology / Case number: #25890J
Giovanni Traverso / Ameya Kirtane / Joshua Bernstock / Alvin Chan / Jonathan Woo / Deepak Subramanian / Simon Qu / Xisha Huang / Hao Song / Taksim Ahmed
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Methods for Versatile Nanoparticle-Protein Conjugation

Technology / Case number: #16763
Timothy K Lu / Zhengtao Deng
Technology Areas: Chemicals & Materials / Electronics & Photonics / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Fluorescent Metal-Based Nitric Oxide Sensor for Live Cells

Technology / Case number: #11806
Mi Hee Lim / Stephen J Lippard
Technology Areas: Chemicals & Materials / Sensing & Imaging / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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One-Step Protein Analysis Using Slanted Nanofilter Array

Technology / Case number: #17391
Sung Ko / Jongyoon Han
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Machine-Learning Optimized Proteins and Enzymes

Technology / Case number: #26015J
Omar Abudayyeh / Jonathan S. Gootenberg / Lukas Villiger / Kaiyi Jiang / Matteo Di Bernardo / Zhaoqing Yan
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Cystic Fibrosis Correction with Programmable Genomic Editing

Technology / Case number: #24666
Omar Abudayyeh / Jonathan S. Gootenberg / Matthew Yarnall / Christopher Fell
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Hydrogel Carriers for Monoclonal Antibody Crystals

Technology / Case number: #21065J
Patrick Doyle / Jeremy Schieferstein / Paul Reichert / Chakravarthy Narasimhan / Amir Erfani Khaneghahi
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Genomic Insertion of Large Cargo with Engineered Retro Elements

Technology / Case number: #23248
Omar Abudayyeh / Jonathan S. Gootenberg / Lukas Villiger / Justin Lim
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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The Design of DNA-scaffolded Subunit Vaccines for Enhanced Germinal Center Responses in HIV Vaccination

Technology / Case number: #25982H
Mark Bathe / Grant Knappe / Anna Romanov / Darrell J Irvine
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Advanced Materials
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Artificially Engineered Protein Hydrogels to Mimic Nucleoporin Selective Gating

Technology / Case number: #17166
Bradley D. Olsen / Minkyu Kim
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Micro Magnetic Resonance Relaxometry (MRR) for Rapid and Non-invasive Detection of iPSC Quality and Differentiation

Technology / Case number: #24427DJE
Sing Yian Chew / Daniel Roxby / Zu Yao Tan / Tan Dai Nguyen / Jongyoon Han
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Advanced Materials
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TOX Inhibitor and Molecular Glue

Technology / Case number: #25241
Angela Koehler / Bocheng Wu
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Novel Ionizable Lipids Suitable For Lipid Nanoparticle Delivery of mRNA to Lung and Nasal Epithelium, As Well As Lung Endothelium

Technology / Case number: #23594Q
Luke Rhym / Allen Jiang / Jacob Witten / Idris Raji / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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New Ionizable Lipid Library Suitable for Multiple Organ Targeting Derived From High Throughput Combinatorial Synthesis and Screening

Technology / Case number: #23406
Bowen Li / Akiva Gordon / Idris Raji / Daniel Anderson
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Ingestible Chemical Energy Harvesting System with Extended Lifetime

Technology / Case number: #23174
Giovanni Traverso / Jason Li / So-Yoon Yang
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Energy & Distribution / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Engineering a Swine Macro-Organ Colorectal Cancer Platform to Combat Transport-Induced Chemotherapy Resistance

Technology / Case number: #22864JQ
Giovanni Traverso / Yunhua Shi / Vance Soares / Daniel Reker / Robert Langer
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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