T Cell Ligand Discovery and Protein Directed Evolution via Lentiviral Surface Display

Exclusively Licensed

Compositions of retroviruses and methods of using the same for gene delivery are disclosed, wherein the retroviruses comprise a viral envelope protein comprising at least one mutation that diminishes its native function, a non-viral membrane-bound protein comprising a membrane-bound domain and an extracellular targeting domain.

Researchers

Michael Birnbaum / Connor Dobson

Departments: Department of Biological Engineering
Technology Areas: Biotechnology: Synthetic Biology / Drug Delivery: Vectors & Virus like Particles
Impact Areas: Healthy Living

  • ligand discovery and gene delivery via retroviral surface display
    United States of America | Granted | 12,222,347
  • ligand discovery and gene delivery via retroviral surface display
    United States of America | Granted | 12,061,187
  • ligand discovery and gene delivery via retroviral surface display
    New Zealand | Pending
  • ligand discovery and gene delivery via retroviral surface display
    United States of America | Published application
  • ligand discovery and gene delivery via retroviral surface display
    Japan | Pending
  • ligand discovery and gene delivery via retroviral surface display
    Australia | Pending
  • ligand discovery and gene delivery via retroviral surface display
    Brazil | Pending
  • ligand discovery and gene delivery via retroviral surface display
    Canada | Published application
  • ligand discovery and gene delivery via retroviral surface display
    China | Published application
  • ligand discovery and gene delivery via retroviral surface display
    Eurasian Patent Organization | Published application
  • ligand discovery and gene delivery via retroviral surface display
    European Patent Convention | Published application
  • ligand discovery and gene delivery via retroviral surface display
    Japan | Granted | 7,658,584
  • ligand discovery and gene delivery via retroviral surface display
    India | Published application
  • ligand discovery and gene delivery via retroviral surface display
    Israel | Pending
  • ligand discovery and gene delivery via retroviral surface display
    Korea (south) | Published application
  • ligand discovery and gene delivery via retroviral surface display
    Mexico | Published application
  • ligand discovery and gene delivery via retroviral surface display
    New Zealand | Pending
  • ligand discovery and gene delivery via retroviral surface display
    Singapore | Pending
  • ligand discovery and gene delivery via retroviral surface display
    Hong Kong | Published application
  • ligand discovery and gene delivery via retroviral surface display
    United States of America | Granted | 12,061,188

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